北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Stereoselective Synthesis of the Trisaccharide Moiety of Ganglioside HLG-2
作者: Xu, Fei-Fei; Wang, Yue; Xiong, De-Cai; Ye, Xin-Shan1
刊名: JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2014-01-17
DOI: 10.1021/jo402378a
卷: 79, 期:2, 页:797-802
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ALPHA-SELECTIVE SIALYLATIONS ; SIALIC-ACID ; O-SIALYLATION ; DONOR ; DICHLOROMETHANE ; THIOSIALOSIDE ; HOLOTHUROIDEA ; CONSTITUENTS ; SIALOSIDES ; EFFICIENT
英文摘要:

The glycan portion of ganglioside HLG-2, which was identified in the extracts of the sea cucumber Holothuria leucospilota, was synthesized in a highly efficient and stereoselective manner. The unusual sequence of the trisaccharide moiety, alpha-N-glycolylsialy1-(2,4)-alpha-N-acetylsialyl-(2,6)-glucoside, was assembled by stereoselective coupling of a 5-N,4-O-carbonyl-protected sialyl phosphate donor, a N-2,2,2-trichloroethoxycarbonyl (Troc)-protected sialyl acceptor, and a (trimethylsily)ethyl-beta-glucosyl acceptor in high yield. The synthesis featured the high-yielding construction of two alpha-sialyl linkages.

语种: 英语
所属项目编号: 21232002 ; 21072014 ; 2012CB822100 ; 2013CB910700
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000330099000034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65256
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Fei-Fei,Wang, Yue,Xiong, De-Cai,et al. Stereoselective Synthesis of the Trisaccharide Moiety of Ganglioside HLG-2[J]. JOURNAL OF ORGANIC CHEMISTRY,2014,79(2):797-802.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xu, Fei-Fei]'s Articles
[Wang, Yue]'s Articles
[Xiong, De-Cai]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xu, Fei-Fei]‘s Articles
[Wang, Yue]‘s Articles
[Xiong, De-Cai]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace