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学科主题: 药学
题名:
Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel
作者: Luo, Li-Min1; Huang, Yue1; Zhao, Bing-Xiang1; Zhao, Xin1; Duan, Yu1; Du, Ruo1; Yu, Ke-Fu1; Song, Ping1; Zhao, Yang1; Zhang, Xuan1; Zhang, Qiang1,2
关键词: Aminopeptidase N (APN) ; Cyclic Asn-Gly-Arg (NGR) ; Paclitaxel (PTX) ; Targeting ; Anti-angiogenic efficacy ; Metronomic administration
刊名: BIOMATERIALS
发表日期: 2013
DOI: 10.1016/j.biomaterials.2012.10.029
卷: 34, 期:4, 页:1102-1114
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: DRUG-DELIVERY SYSTEMS ; TUMOR VASCULATURE ; IN-VITRO ; THERAPEUTIC-EFFICACY ; ENDOTHELIAL-CELLS ; RESISTANT CANCER ; AMINOPEPTIDASE N ; CHEMOTHERAPY ; DOXORUBICIN ; INHIBITION
英文摘要:

In the present study, we prepared NGR-modified sterically stabilized liposomes containing paclitaxel (NGR-SSL-PTX) in order to evaluate their potential targeting to aminopeptidase N receptors expressed on tumor endothelial cells and the tumor cell surface and its anti-angiogenic activity following metronomic administration. NGR-SSL-PTX was prepared by a thin-film hydration method. The in vitro targeting characteristics of NGR-modified liposomes on HUVEC (human umbilical vein endothelial cells), HT1080 (human fibrosarcoma cells) and MCF-7 (human breast adenocarcinoma cells) were then investigated. The effect of NGR-SSL-PTX on HUVEC proliferation and migration was also tested. The pharmacokinetics of NGR-SSL-PTX was studied in rats. The in vivo targeting activity of NGR-modified liposomes was investigated in HT1080 tumor-bearing mice. The anti-tumor activity of NGR-SSL-PIX following metronomic administration was evaluated in HT1080 tumor-bearing mice in vivo. The targeting activity of the NGR-modified liposomes was demonstrated by in vitro flow cytometry and confocal microscopy as well as in vivo confocal immunofluorescence microscopy and bio-distribution experiments. The results of endothelial cell proliferation and migration and microvessel density (MVD) confirmed the anti-angiogenic activity of NGR-SSL-PTX in vitro and in vivo. The sustained circulation of NGR-SSL-PTX was shown in the pharmacokinetic study. NGR-SSL-PTX is able to improve treatment efficacy producing the most significant anti-tumor activity and anti-angiogenic following metronomic administration. (C) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30873170 ; 81172992 ; 2009CB930300 ; 2013CB932501 ; BMU20110263
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Innovation Team of Ministry of Education
WOS记录号: WOS:000313155800024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65258
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Luo, Li-Min,Huang, Yue,Zhao, Bing-Xiang,et al. Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel[J]. BIOMATERIALS,2013,34(4):1102-1114.
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