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Preparation, characterization and pharmacokinetics of Amoitone B-loaded long circulating nanostructured lipid carriers
Luan, Jingjing1; Zhang, Dianrui1; Hao, Leilei1; Qi, Lisi1; Liu, Xinquan1; Guo, Hejian1; Li, Caiyun1; Guo, Yuanyuan1; Li, Tingting1; Zhang, Qiang2; Zhai, Guangxi1
关键词Amoitone B Nanostructured lipid carriers Long circulation In vitro release Pharmacokinetics
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
2014-02-01
DOI10.1016/j.colsurfb.2013.10.018
114页:255-260
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]Biophysics ; Chemistry ; Materials Science
关键词[WOS]ORPHAN NUCLEAR RECEPTORS ; CANCER-CELLS ; DRUG-DELIVERY ; IN-VITRO ; NUR77 ; NANOPARTICLES ; TECHNOLOGY ; PACLITAXEL ; APOPTOSIS ; VIVO
英文摘要

Amoitone B, chemically synthesized as the derivative of Cytosporone B, is a powerful agonist for Nur77 receptor. It has outstanding anticancer activity in vivo. However, the water-insolubility and short biological half-life lead to poor bioavailability, which limits its application. The aim of this study was to develop polyethylene glycol-coated Amoitone B-loaded nanostructured lipid carriers (AmB-PEG-NLC) for parenteral delivery of Amoitone B to prolong drug circulation time in body and enhance the bioavailability. AmB-PEG-NLC were prepared by emulsion-evaporation and low temperature-solidification method, while Amoitone B-loaded NLC (AmB-NLC) were also prepared as control. The characteristics of AmB-PEG-NLC and AmB-NLC such as particle size, zeta potential, entrapment efficiency and drug loading were investigated in detail. The mean particle size was about 200 nm and the zeta potential value was about - 15 mV. The X-ray diffraction analysis demonstrated that Amoitone B was not in crystalline state in NLC (AmB-PEG-NLC and AmB-NLC). Drug release pattern with burst release initially and prolonged release afterwards was obtained in vitro for AmB-PEG-NLC. Furthermore, AmB-PEG-NLC exhibited prolonged MRT (mean residence time) and higher AUC (area under drug concentration-time curve) compared with AmB-NLC as well as Amoitone B solution. These results indicated that AmB-PEG-NLC could be a promising delivery system for Amoitone B to prolong the circulation time in body and thus improve its bioavailability. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000331596100034
项目编号2009CB930300
资助机构National Basic Research Program of China (973 Program)
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65262
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Coll Pharm, Jinan 250012, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Luan, Jingjing,Zhang, Dianrui,Hao, Leilei,et al. Preparation, characterization and pharmacokinetics of Amoitone B-loaded long circulating nanostructured lipid carriers[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,114:255-260.
APA Luan, Jingjing.,Zhang, Dianrui.,Hao, Leilei.,Qi, Lisi.,Liu, Xinquan.,...&Zhai, Guangxi.(2014).Preparation, characterization and pharmacokinetics of Amoitone B-loaded long circulating nanostructured lipid carriers.COLLOIDS AND SURFACES B-BIOINTERFACES,114,255-260.
MLA Luan, Jingjing,et al."Preparation, characterization and pharmacokinetics of Amoitone B-loaded long circulating nanostructured lipid carriers".COLLOIDS AND SURFACES B-BIOINTERFACES 114(2014):255-260.
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