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学科主题: 基础医学
题名:
The genome of Salmonella entetica serovar Gallinarum: Distinct insertions/deletions and rare rearrangements
作者: Wu, KY; Liu, GR; Liu, WQ; Wang, AQ; Zhan, S; Sanderson, KE; Johnston, RN; Liu, SL
刊名: JOURNAL OF BACTERIOLOGY
发表日期: 2005-07-01
DOI: 10.1128/JB.187.14.4720-4727.2005
卷: 187, 期:14, 页:4720-4727
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: LATERAL GENE-TRANSFER ; RIBOSOMAL-RNA GENES ; ESCHERICHIA-COLI ; CLEAVAGE MAP ; TYPHIMURIUM LT2 ; HOMOLOGOUS RECOMBINATION ; CHLAMYDOMONAS-EUGAMETOS ; TYPHI STRAINS ; RRN OPERONS ; ENTERICA
英文摘要:

Salmonella enterica serovar Gallinarum is a fowl-adapted pathogen, causing typhoid fever in chickens. It has the same antigenic formula (1,9,12:-:-) as S. enterica serovar Pullorum, which is also adapted to fowl but causes pullorum disease (diarrhea). The close relatedness but distinct pathogeneses make this pair of fowl pathogens good models for studies of bacterial genomic evolution and the way these organisms acquired pathogenicity. To locate and characterize the genomic differences between serovar Gallinarum and other salmonellae, we constructed a physical map of serovar Gallinarum strain SARB21 by using I-CeuI, XbaI, and AvrII with pulsed-field gel electrophoresis techniques. In the 4,740-kb genome, we located two insertions and six deletions relative to the genome of S. enterica serovar Typhimurium LT2, which we used as a reference Salmonella genome. Four of the genomic regions with reduced lengths corresponded to the four prophages in the genome of serovar Typhimurium LT2, and the others contained several smaller deletions relative to serovar Typhimurium LT2, including regions containing srfJ, std, and stj and gene clusters encoding a type I restriction system in serovar Typhimurium LT2. The map also revealed some rare rearrangements, including two inversions and several translocations. Further characterization of these insertions, deletions, and rearrangements will provide new insights into the molecular basis for the specific host-pathogen interactions and mechanisms of genomic evolution to create a new pathogen.

语种: 英语
WOS记录号: WOS:000230350500004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65266
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada
2.Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada
3.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing, Peoples R China
4.Univ Calgary, Dept Biol Sci, Calgary, AB T2N 4N1, Canada

Recommended Citation:
Wu, KY,Liu, GR,Liu, WQ,et al. The genome of Salmonella entetica serovar Gallinarum: Distinct insertions/deletions and rare rearrangements[J]. JOURNAL OF BACTERIOLOGY,2005,187(14):4720-4727.
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