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学科主题基础医学
The genome of Salmonella entetica serovar Gallinarum: Distinct insertions/deletions and rare rearrangements
Wu, KY; Liu, GR; Liu, WQ; Wang, AQ; Zhan, S; Sanderson, KE; Johnston, RN; Liu, SL
刊名JOURNAL OF BACTERIOLOGY
2005-07-01
DOI10.1128/JB.187.14.4720-4727.2005
187期:14页:4720-4727
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology
研究领域[WOS]Microbiology
关键词[WOS]LATERAL GENE-TRANSFER ; RIBOSOMAL-RNA GENES ; ESCHERICHIA-COLI ; CLEAVAGE MAP ; TYPHIMURIUM LT2 ; HOMOLOGOUS RECOMBINATION ; CHLAMYDOMONAS-EUGAMETOS ; TYPHI STRAINS ; RRN OPERONS ; ENTERICA
英文摘要

Salmonella enterica serovar Gallinarum is a fowl-adapted pathogen, causing typhoid fever in chickens. It has the same antigenic formula (1,9,12:-:-) as S. enterica serovar Pullorum, which is also adapted to fowl but causes pullorum disease (diarrhea). The close relatedness but distinct pathogeneses make this pair of fowl pathogens good models for studies of bacterial genomic evolution and the way these organisms acquired pathogenicity. To locate and characterize the genomic differences between serovar Gallinarum and other salmonellae, we constructed a physical map of serovar Gallinarum strain SARB21 by using I-CeuI, XbaI, and AvrII with pulsed-field gel electrophoresis techniques. In the 4,740-kb genome, we located two insertions and six deletions relative to the genome of S. enterica serovar Typhimurium LT2, which we used as a reference Salmonella genome. Four of the genomic regions with reduced lengths corresponded to the four prophages in the genome of serovar Typhimurium LT2, and the others contained several smaller deletions relative to serovar Typhimurium LT2, including regions containing srfJ, std, and stj and gene clusters encoding a type I restriction system in serovar Typhimurium LT2. The map also revealed some rare rearrangements, including two inversions and several translocations. Further characterization of these insertions, deletions, and rearrangements will provide new insights into the molecular basis for the specific host-pathogen interactions and mechanisms of genomic evolution to create a new pathogen.

语种英语
WOS记录号WOS:000230350500004
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65266
专题北京大学基础医学院_病原生物学系
作者单位1.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada
2.Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada
3.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing, Peoples R China
4.Univ Calgary, Dept Biol Sci, Calgary, AB T2N 4N1, Canada
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GB/T 7714
Wu, KY,Liu, GR,Liu, WQ,et al. The genome of Salmonella entetica serovar Gallinarum: Distinct insertions/deletions and rare rearrangements[J]. JOURNAL OF BACTERIOLOGY,2005,187(14):4720-4727.
APA Wu, KY.,Liu, GR.,Liu, WQ.,Wang, AQ.,Zhan, S.,...&Liu, SL.(2005).The genome of Salmonella entetica serovar Gallinarum: Distinct insertions/deletions and rare rearrangements.JOURNAL OF BACTERIOLOGY,187(14),4720-4727.
MLA Wu, KY,et al."The genome of Salmonella entetica serovar Gallinarum: Distinct insertions/deletions and rare rearrangements".JOURNAL OF BACTERIOLOGY 187.14(2005):4720-4727.
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