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Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway
Ren Tingting; Guo Wei; Peng Changliang; Lu Xinchang; Yang-Yi
关键词arsenic trioxide osteosarcoma HOS MNNG migration invasion MAPK
刊名CANCER BIOLOGY & THERAPY
2010-08-01
10期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]PROGNOSTIC-FACTORS ; KAPPA-B ; AS2O3 ; CARCINOMA ; TRIAL ; CHEMOTHERAPY ; APOPTOSIS ; PROSTATE ; SARCOMA ; CANCER
英文摘要

Arsenic trioxide (As(2)O(3)) is an active ingredient in a traditional Chinese medicine. Recent studies showed that it causes apoptosis in several cancer cells. However, research of As(2)O(3) in osteosarcoma is sparse. In our present study, an inhibitory effect of As(2)O(3) on osteosarcoma cell adhesion and metastasis was observed with a cell adhesion, migration and invasion test. The impact of As(2)O(3) on the activities of MMP-9 and MAPK pathway-related downstream factors was analyzed by western blotting. Our results showed that As(2)O(3) significantly inhibited motility, migration and invasion in HOS and MNNG cells in a concentration-dependent manner at concentrations ranging from 0.5-2 mu M, and led to cytoskeletal rearrangements. As(2)O(3) exerted an inhibitory effect on the phosphorylation of ERK1/2 and MEK, which are the members of the MAPK family. Additionally, treatment with As(2)O(3) in combination with inhibitors specific for MEK (U0126) in HOS and MNNG cells resulted in a marked inhibition of cell invasion and As(2)O(3) could significantly reduce PMA-induced invasion. In conclusion, we demonstrate the inhibitory effects of As(2)O(3) on the invasiveness of HOS and MNNG cells, which may be due at least partly to inactivation of the MAPK signaling pathway.

语种英语
WOS记录号WOS:000281005600006
项目编号2005-1009
资助机构Capital Medical Development and Research Foundation
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65267
专题北京大学第二临床医学院_骨肿瘤科
北京大学药学院_天然药物与仿生药物国家重点实验室
作者单位Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100871, Peoples R China
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GB/T 7714
Ren Tingting,Guo Wei,Peng Changliang,et al. Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway[J]. CANCER BIOLOGY & THERAPY,2010,10(3).
APA Ren Tingting,Guo Wei,Peng Changliang,Lu Xinchang,&Yang-Yi.(2010).Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway.CANCER BIOLOGY & THERAPY,10(3).
MLA Ren Tingting,et al."Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway".CANCER BIOLOGY & THERAPY 10.3(2010).
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