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IR@PKUHSC  > 北京大学第二临床医学院  > 骨肿瘤科  > 期刊论文
学科主题: 临床医学
题名:
Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway
作者: Ren Tingting; Guo Wei; Peng Changliang; Lu Xinchang; Yang-Yi
关键词: arsenic trioxide ; osteosarcoma ; HOS ; MNNG ; migration ; invasion ; MAPK
刊名: CANCER BIOLOGY & THERAPY
发表日期: 2010-08-01
卷: 10, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PROGNOSTIC-FACTORS ; KAPPA-B ; AS2O3 ; CARCINOMA ; TRIAL ; CHEMOTHERAPY ; APOPTOSIS ; PROSTATE ; SARCOMA ; CANCER
英文摘要:

Arsenic trioxide (As(2)O(3)) is an active ingredient in a traditional Chinese medicine. Recent studies showed that it causes apoptosis in several cancer cells. However, research of As(2)O(3) in osteosarcoma is sparse. In our present study, an inhibitory effect of As(2)O(3) on osteosarcoma cell adhesion and metastasis was observed with a cell adhesion, migration and invasion test. The impact of As(2)O(3) on the activities of MMP-9 and MAPK pathway-related downstream factors was analyzed by western blotting. Our results showed that As(2)O(3) significantly inhibited motility, migration and invasion in HOS and MNNG cells in a concentration-dependent manner at concentrations ranging from 0.5-2 mu M, and led to cytoskeletal rearrangements. As(2)O(3) exerted an inhibitory effect on the phosphorylation of ERK1/2 and MEK, which are the members of the MAPK family. Additionally, treatment with As(2)O(3) in combination with inhibitors specific for MEK (U0126) in HOS and MNNG cells resulted in a marked inhibition of cell invasion and As(2)O(3) could significantly reduce PMA-induced invasion. In conclusion, we demonstrate the inhibitory effects of As(2)O(3) on the invasiveness of HOS and MNNG cells, which may be due at least partly to inactivation of the MAPK signaling pathway.

语种: 英语
所属项目编号: 2005-1009
项目资助者: Capital Medical Development and Research Foundation
WOS记录号: WOS:000281005600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65267
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Ren Tingting,Guo Wei,Peng Changliang,et al. Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway[J]. CANCER BIOLOGY & THERAPY,2010,10(3).
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