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学科主题临床医学
Chemokine (C-C motif) ligand 5-28C > G is significantly associated with an increased risk of tuberculosis: a meta-analysis
Hu, Lelin1,2; Zhang, Kaixian3; Yao, Lihong1; Wang, Junjie1
关键词CCL5 polymorphism TB meta-analysis
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015
8期:8页:13211-13218
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]PULMONARY TUBERCULOSIS ; GENE POLYMORPHISMS ; MYCOBACTERIUM-TUBERCULOSIS ; RANTES ; CCL5 ; SUSCEPTIBILITY ; PROMOTER ; INDIA ; CCR5
英文摘要

Objective: Chemokine (C-C motif) ligand 5 (CCL5) has been shown to play an important role in antimycobacterial immune responses. Previous studies have extensively reported that the CCL5 -28C>G gene polymorphism is associated with susceptibility to tuberculosis (TB). However, the results of these studies have been inconsistent. To investigate the relationship between the CCL5 -28C>G and the risk of TB, we performed a meta-analysis. Methods: We searched articles published before June 6, 2014 from PubMed, CNKI, and Wanfang databases. Data were extracted from all eligible publications independently by two investigators and statistically analyzed. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the strength of the association between CCL5 polymorphism and TB. Results: Four case-control studies including 647 TB cases and 726 controls were involved in the meta-analysis. Our meta-analysis indicated the CCL5 -28C>G gene polymorphism was significantly associated with increased risk of TB (G vs. C: 3.75, 95% CI = 1.76-7.99; GG vs. CC: OR = 30.26, 95% CI = 14.28-64.12). Conclusion: Our results suggested that the -28C>G polymorphism is significantly associated with higher TB risk, which is opposite from previously published reports. However, the number of the study is limited, additional well-designed studies are required to elucidate the association between the CCL5 -28C>G gene polymorphism and TB.

语种英语
WOS记录号WOS:000365271900147
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65270
专题北京大学第三临床医学院_肿瘤放疗科
作者单位1.Peking Univ, Hosp 3, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Anhui Univ Sci & Technol, Sch Med, Dept Med Immunol, Huainan 232001, Anhui, Peoples R China
3.Jining Med Coll, Teng Zhou Cent Peoples Hosp, Dept Oncol, Teng Zhou 277599, Shandong, Peoples R China
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GB/T 7714
Hu, Lelin,Zhang, Kaixian,Yao, Lihong,et al. Chemokine (C-C motif) ligand 5-28C > G is significantly associated with an increased risk of tuberculosis: a meta-analysis[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(8):13211-13218.
APA Hu, Lelin,Zhang, Kaixian,Yao, Lihong,&Wang, Junjie.(2015).Chemokine (C-C motif) ligand 5-28C > G is significantly associated with an increased risk of tuberculosis: a meta-analysis.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,8(8),13211-13218.
MLA Hu, Lelin,et al."Chemokine (C-C motif) ligand 5-28C > G is significantly associated with an increased risk of tuberculosis: a meta-analysis".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8.8(2015):13211-13218.
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