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学科主题: 临床医学
题名:
Chemokine (C-C motif) ligand 5-28C > G is significantly associated with an increased risk of tuberculosis: a meta-analysis
作者: Hu, Lelin1,2; Zhang, Kaixian3; Yao, Lihong1; Wang, Junjie1
关键词: CCL5 ; polymorphism ; TB ; meta-analysis
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:8, 页:13211-13218
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: PULMONARY TUBERCULOSIS ; GENE POLYMORPHISMS ; MYCOBACTERIUM-TUBERCULOSIS ; RANTES ; CCL5 ; SUSCEPTIBILITY ; PROMOTER ; INDIA ; CCR5
英文摘要:

Objective: Chemokine (C-C motif) ligand 5 (CCL5) has been shown to play an important role in antimycobacterial immune responses. Previous studies have extensively reported that the CCL5 -28C>G gene polymorphism is associated with susceptibility to tuberculosis (TB). However, the results of these studies have been inconsistent. To investigate the relationship between the CCL5 -28C>G and the risk of TB, we performed a meta-analysis. Methods: We searched articles published before June 6, 2014 from PubMed, CNKI, and Wanfang databases. Data were extracted from all eligible publications independently by two investigators and statistically analyzed. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the strength of the association between CCL5 polymorphism and TB. Results: Four case-control studies including 647 TB cases and 726 controls were involved in the meta-analysis. Our meta-analysis indicated the CCL5 -28C>G gene polymorphism was significantly associated with increased risk of TB (G vs. C: 3.75, 95% CI = 1.76-7.99; GG vs. CC: OR = 30.26, 95% CI = 14.28-64.12). Conclusion: Our results suggested that the -28C>G polymorphism is significantly associated with higher TB risk, which is opposite from previously published reports. However, the number of the study is limited, additional well-designed studies are required to elucidate the association between the CCL5 -28C>G gene polymorphism and TB.

语种: 英语
WOS记录号: WOS:000365271900147
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65270
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Anhui Univ Sci & Technol, Sch Med, Dept Med Immunol, Huainan 232001, Anhui, Peoples R China
3.Jining Med Coll, Teng Zhou Cent Peoples Hosp, Dept Oncol, Teng Zhou 277599, Shandong, Peoples R China

Recommended Citation:
Hu, Lelin,Zhang, Kaixian,Yao, Lihong,et al. Chemokine (C-C motif) ligand 5-28C > G is significantly associated with an increased risk of tuberculosis: a meta-analysis[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(8):13211-13218.
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