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学科主题基础医学
Expression of mouse membrane-associated prostaglandin E-2 synthase-2 (mPGES-2) along the urogenital tract
Yang, Guangrui; Chen, Lihong; Zhang, Yahua; Zhang, Xiaoyan; Wu, Jing; Li, Shuo; Wei, Mingfen; Zhang, Zhiwen; Breyer, Matthew D.; Guan, Youfei
关键词prostaglandin E-2 membrane-associated PGE(2) synthase-2 PGES gene expression urogenital system
刊名BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
2006-12-01
DOI10.1016/j.bbalip.2006.06.018
1761期:12页:1459-1468
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]RAT PERITONEAL-MACROPHAGES ; RECEPTOR SUBTYPE EP2 ; PORCINE LUTEAL CELLS ; GENE-EXPRESSION ; MICE LACKING ; CYCLOOXYGENASE ISOZYMES ; PERIIMPLANTATION PERIOD ; REDUCED FERTILITY ; COLLECTING DUCT ; PGE SYNTHASE-1
英文摘要

Prostaglandin E-2 (PGE(2)) is the most common prostanoid and has a variety of bioactivities including a crucial role in urogenital function. Multiple enzymes are involved in its biosynthesis. Among 3 PGE(2) terminal synthetic enzymes, membrane-associated PGE(2) synthase-2 (mPGES-2) is the most recently identified, and its role remains uncharacterized. In previous studies, membrane-associated PGE(2) synthase-1 (mPGES-1) and cytosolic PGE(2) synthase (OGES) were reported to be expressed along the urogenital tracts. Here we report the genomic structure and tissue distribution of mPGES-2 in the urogenital system. Analysis of several bioinformatic databases demonstrated that mouse mPGES-2 spans 7 kb and consists of 7 exons. The mPGES-2 promoter contains multiple Sp1 sites and a GC box without a TATA box motif Real-time quantitative PCR revealed that constitutive mPGES-2 mRNA was most abundant in the heart, brain, kidney and small intestine. In the urogenital system, mPGES-2 was highly expressed in the renal cortex, followed by the renal medulla and ovary, with lower levels in the ureter, bladder and uterus. Immunohistochemistry studies indicated that mPGES-2 was ubiquitously expressed along the nephron, with much lower levels in the glomeruli. In the ureter and bladder, mPGES-2 was mainly localized to the urothelium. In the reproductive system, mPGES-2 was restricted to the epithelial cells of the testis, epididymis, vas deferens and seminal vesicle in males, and oocytes, stroma cells and corpus luteum of the ovary and epithelial cells of the oviduct and uterus in females. This expression pattern is consistent with an important role for mPGES-2-mediated PGE(2) in urogenital function. (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000243153800007
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65273
Collection北京大学基础医学院_北京大学糖尿病中心
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Diabet, Beijing 100083, Peoples R China
3.Vanderbilt Univ, Med Ctr, Div Nephrol, Nashville, TN 37232 USA
Recommended Citation
GB/T 7714
Yang, Guangrui,Chen, Lihong,Zhang, Yahua,et al. Expression of mouse membrane-associated prostaglandin E-2 synthase-2 (mPGES-2) along the urogenital tract[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,2006,1761(12):1459-1468.
APA Yang, Guangrui.,Chen, Lihong.,Zhang, Yahua.,Zhang, Xiaoyan.,Wu, Jing.,...&Guan, Youfei.(2006).Expression of mouse membrane-associated prostaglandin E-2 synthase-2 (mPGES-2) along the urogenital tract.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,1761(12),1459-1468.
MLA Yang, Guangrui,et al."Expression of mouse membrane-associated prostaglandin E-2 synthase-2 (mPGES-2) along the urogenital tract".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1761.12(2006):1459-1468.
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