IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Plasma catecholamine release-inhibitory peptide catestatin in patients with essential hypertension
Meng, Lei; Ye, Xiao-jin; Ding, Wen-hui; Yang, Ying; Di, Bei-bing; Liu, Lin; Huo, Yong
关键词catestatin essential hypertension left ventricular hypertrophy
刊名JOURNAL OF CARDIOVASCULAR MEDICINE
2011-09-01
DOI10.2459/JCM.0b013e328346c142
12期:9页:643-647
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者Medical Development of the Capital ; Medical Development of the Capital
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]LEFT-VENTRICULAR HYPERTROPHY ; CHROMOGRANIN-A FRAGMENT ; BLOOD-PRESSURE ; IN-VIVO ; A(344-364)
英文摘要

Background Catestatin plays an important role in the adjustment of blood pressure and cardiac function. We investigated levels of plasma catestatin in essential hypertension and the relationship between catestatin and left ventricular hypertrophy.

Methods Plasma was collected from 136 patients with essential hypertension and 61 healthy controls. Plasma catestatin was measured by enzyme-linked immunosorbent assay (ELISA). Plasma norepinephrine was measured by high-performance liquid chromatography. All patients underwent echocardiography, measurement of fasting blood glucose, body mass index (BMI) and lipid levels.

Results Plasma levels of catestatin and norepinephrine were significantly higher in patients with essential hypertension than in normal controls (both P<0.01). The ratio of catestatin to norepinephrine was significantly lower in patients with essential hypertension than in normal controls (P<0.01). In patients with essential hypertension, plasma norepinephrine level was significantly higher in patients with than without left ventricular hypertrophy (P<0.01). Plasma catestatin level was lower, but not significantly, in patients with than without left ventricular hypertrophy. The ratio of catestatin to norepinephrine was significantly lower in patients with than without left ventricular hypertrophy (P<0.01).

Conclusion Plasma catestatin is elevated in patients with essential hypertension. The ratio of catestatin to norepinephrine was lower in patients with left ventricular hypertrophy. Catestatin might participate in the development of hypertension and left ventricular hypertrophy.

语种英语
所属项目编号2009-3026
资助者Medical Development of the Capital ; Medical Development of the Capital
WOS记录号WOS:000293836800006
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65275
Collection北京大学第一临床医学院_心血管内科
作者单位Peking Univ First Hosp, Dept Cardiol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Meng, Lei,Ye, Xiao-jin,Ding, Wen-hui,et al. Plasma catecholamine release-inhibitory peptide catestatin in patients with essential hypertension[J]. JOURNAL OF CARDIOVASCULAR MEDICINE,2011,12(9):643-647.
APA Meng, Lei.,Ye, Xiao-jin.,Ding, Wen-hui.,Yang, Ying.,Di, Bei-bing.,...&Huo, Yong.(2011).Plasma catecholamine release-inhibitory peptide catestatin in patients with essential hypertension.JOURNAL OF CARDIOVASCULAR MEDICINE,12(9),643-647.
MLA Meng, Lei,et al."Plasma catecholamine release-inhibitory peptide catestatin in patients with essential hypertension".JOURNAL OF CARDIOVASCULAR MEDICINE 12.9(2011):643-647.
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