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Spectral studies on the interaction between platinum(II) complexs with different conformation with G-actin
An, F; Wang, SH; Zhang, DS; Cheng, BW; Wang, K
关键词cyclohexamethylene-diamine squaric acid platinum(II) complexs G-actin conformation
刊名CHINESE JOURNAL OF INORGANIC CHEMISTRY
2004-09-01
20期:9页:1101-1104
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear
研究领域[WOS]Chemistry
英文摘要

The cyclohexamethylene-diamine squaric acid platinum(II) complexs (R,R, SS) binding to G-actin and the consquence conformation change were studied by N-(1-pyrenyl) maleimide(NPM) labeled fluorescence and intrinsic fluorescence. The binding and chemical kinetics were determined by fluorometry. The results showed that when R (Pt/actin molar ratio) was lower than 30, the Pt binded to G-actin strong binding sites(-SH), when R was larger than 30, the Pt binded to G-actin weaker binding sites. The consquence conformation changes were determined by CD. The CD results showed that R was smaller than 60, G-actin alpha-helix contents decreased slowly, R was larger than 60, G-actin conformation changed obviously. The reaction of R,R complex of platinum(R) S,S complex of platinum(II) with G-actin was similar to that of with S,S complex of platinum(II).

语种中文
WOS记录号WOS:000223713500020
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65276
Collection北京大学药学院
作者单位1.Hebei N Univ, Dept Chem & Pharmacol, Zhangjiakou 075029, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
An, F,Wang, SH,Zhang, DS,et al. Spectral studies on the interaction between platinum(II) complexs with different conformation with G-actin[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2004,20(9):1101-1104.
APA An, F,Wang, SH,Zhang, DS,Cheng, BW,&Wang, K.(2004).Spectral studies on the interaction between platinum(II) complexs with different conformation with G-actin.CHINESE JOURNAL OF INORGANIC CHEMISTRY,20(9),1101-1104.
MLA An, F,et al."Spectral studies on the interaction between platinum(II) complexs with different conformation with G-actin".CHINESE JOURNAL OF INORGANIC CHEMISTRY 20.9(2004):1101-1104.
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