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学科主题: 临床医学
题名:
Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy
作者: Jin, Yushen2; Wang, Jinrui3; Ke, Hengte2; Wang, Shumin3; Dai, Zhifei1
关键词: Microcapsules ; Photothermal therapy ; Computed tomography ; Ultrasound imaging ; Theranostic agent
刊名: BIOMATERIALS
发表日期: 2013-07-01
DOI: 10.1016/j.biomaterials.2013.03.027
卷: 34, 期:20, 页:4794-4802
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: ULTRASOUND CONTRAST AGENTS ; RAY COMPUTED-TOMOGRAPHY ; IN-VIVO ; CANCER ; PLATFORM ; CELLS
英文摘要:

Theranostic microcapsules were successfully fabricated by introducing gold nanoparticles into poly(lactic acid) microcapsules through a double-microemulsion method, followed by depositing graphene oxide onto the microcapsule surface via electrostatic layer-by-layer self-assembly technique. It was proved that the obtained microcapsules could serve as a contrast agent to simultaneously enhance US imaging and X-ray CT imaging greatly both in vitro and in vivo. In addition, the in vivo therapeutic examinations showed that the microcapsule was an effective agent for photothermal therapy of cancer. The near-infrared laser light ablated the tumor completely within 9 days in the presence of the microcapsules and the tumor growth inhibition was 83.8%. The combination of real-time ultrasound with 3-D computed tomography through a single microcapsule agent is very helpful for accurately interpreting the obtained images, identifying the size and location of the tumor, as well as guiding and monitoring the photothermal therapy. Simultaneously, the effectiveness of photothermal therapy could be evaluated by the combined US and CT imaging enhanced by the microcapsule agent. Such a versatile microcapsule system might bring opportunities to the next generation of multimodal imaging guided cancer therapy. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81225011 ; 81230036 ; 21273014 ; 81101094
项目资助者: National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
WOS记录号: WOS:000318464200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65281
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Harbin Inst Technol, Nanomed & Biosensor Lab, Sch Life Sci & Technol, Harbin 150080, Peoples R China
3.Peking Univ, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Jin, Yushen,Wang, Jinrui,Ke, Hengte,et al. Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy[J]. BIOMATERIALS,2013,34(20):4794-4802.
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