IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy
Jin, Yushen2; Wang, Jinrui3; Ke, Hengte2; Wang, Shumin3; Dai, Zhifei1
关键词Microcapsules Photothermal therapy Computed tomography Ultrasound imaging Theranostic agent
刊名BIOMATERIALS
2013-07-01
DOI10.1016/j.biomaterials.2013.03.027
34期:20页:4794-4802
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]ULTRASOUND CONTRAST AGENTS ; RAY COMPUTED-TOMOGRAPHY ; IN-VIVO ; CANCER ; PLATFORM ; CELLS
英文摘要

Theranostic microcapsules were successfully fabricated by introducing gold nanoparticles into poly(lactic acid) microcapsules through a double-microemulsion method, followed by depositing graphene oxide onto the microcapsule surface via electrostatic layer-by-layer self-assembly technique. It was proved that the obtained microcapsules could serve as a contrast agent to simultaneously enhance US imaging and X-ray CT imaging greatly both in vitro and in vivo. In addition, the in vivo therapeutic examinations showed that the microcapsule was an effective agent for photothermal therapy of cancer. The near-infrared laser light ablated the tumor completely within 9 days in the presence of the microcapsules and the tumor growth inhibition was 83.8%. The combination of real-time ultrasound with 3-D computed tomography through a single microcapsule agent is very helpful for accurately interpreting the obtained images, identifying the size and location of the tumor, as well as guiding and monitoring the photothermal therapy. Simultaneously, the effectiveness of photothermal therapy could be evaluated by the combined US and CT imaging enhanced by the microcapsule agent. Such a versatile microcapsule system might bring opportunities to the next generation of multimodal imaging guided cancer therapy. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000318464200010
项目编号81225011 ; 81230036 ; 21273014 ; 81101094
资助机构National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
引用统计
被引频次:97[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65281
专题北京大学第三临床医学院
作者单位1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Harbin Inst Technol, Nanomed & Biosensor Lab, Sch Life Sci & Technol, Harbin 150080, Peoples R China
3.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Jin, Yushen,Wang, Jinrui,Ke, Hengte,et al. Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy[J]. BIOMATERIALS,2013,34(20):4794-4802.
APA Jin, Yushen,Wang, Jinrui,Ke, Hengte,Wang, Shumin,&Dai, Zhifei.(2013).Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy.BIOMATERIALS,34(20),4794-4802.
MLA Jin, Yushen,et al."Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy".BIOMATERIALS 34.20(2013):4794-4802.
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