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Pyrimidone derivative inhibits simian immunodeficiency virus-induced apoptosis of CEM x 174 cells
Gao, Libo1; Fu, Shigan2; Li, Hui1; Wang, Xiaowei3; Liu, Junyi3; Liu, Han1; Guo, Liyuan1; Liu, Xinhua1; Li, Mengsen1; McNutt, Michael A.4; Li, Gang1
关键词Apoptosis Cell cycle Pyrimidone Reverse transcriptase Simian immunodeficiency virus
刊名CELL BIOLOGY INTERNATIONAL
2009-02-01
DOI10.1016/j.cellbi.2008.11.005
33期:2页:207-216
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]REVERSE-TRANSCRIPTASE INHIBITORS ; LYMPHOCYTE APOPTOSIS ; NONNUCLEOSIDE INHIBITORS ; HIV-INFECTION ; G(1) PHASE ; IN-VITRO ; TYPE-1 ; MECHANISM ; CYCLE ; NEURODEGENERATION
英文摘要

The biochemical effects of 2-(ethoxymethylthio)-9-phenyl-cyclohepta[d] pyrimidone (EPCP), a novel non-nucleoside reverse transcriptase inhibitor, have been investigated. Treatment with EPCP (EC(50) of 0.88 nM in CEM x174 cells) significantly inhibited the activity of SIV reverse transcriptase and elevated the percentage of viable cells in an SIV-infected sample in a dose-dependent manner. The percentage of cells accumulated in G1 phase increased significantly from 34.5 to 62.4%, with a concomitant reduction in S-phase from 50.7% in the control to 22.6% in the infected group. This cell cycle profile was restored by treatment with EPCP. SIV upregulated the levels of the caspase-3, p53 and bax proteins, and downregulated the level of bcl-2 in infected cells. The apoptotic effect of SIV was also blocked by treatment with EPCP. The pharmacological effects of EPCP paralleled those of AZT, suggesting the possibility that EPCP might be a novel antiviral agent for SIV. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000262980300011
项目编号30621002 ; 30671856 ; 30772536
资助机构National Natural Science Foundation of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65282
专题北京大学药学院_化学生物学系
北京大学基础医学院
北京大学口腔医学院_护理部
作者单位1.Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100083, Peoples R China
4.Hainan Med Collage, Dept Pathophysiol, Haikou 570102, Peoples R China
推荐引用方式
GB/T 7714
Gao, Libo,Fu, Shigan,Li, Hui,et al. Pyrimidone derivative inhibits simian immunodeficiency virus-induced apoptosis of CEM x 174 cells[J]. CELL BIOLOGY INTERNATIONAL,2009,33(2):207-216.
APA Gao, Libo.,Fu, Shigan.,Li, Hui.,Wang, Xiaowei.,Liu, Junyi.,...&Li, Gang.(2009).Pyrimidone derivative inhibits simian immunodeficiency virus-induced apoptosis of CEM x 174 cells.CELL BIOLOGY INTERNATIONAL,33(2),207-216.
MLA Gao, Libo,et al."Pyrimidone derivative inhibits simian immunodeficiency virus-induced apoptosis of CEM x 174 cells".CELL BIOLOGY INTERNATIONAL 33.2(2009):207-216.
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