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学科主题: 基础医学
题名:
Dysregulation of HSG triggers vascular proliferative disorders
作者: Chen, KH; Guo, XM; Ma, DL; Guo, YH; Li, QA; Yang, DM; Li, PF; Qiu, XY; Wen, SJ; Xiao, RP; Tang, JA
刊名: NATURE CELL BIOLOGY
发表日期: 2004-09-01
DOI: 10.1038/ncb/1161
卷: 6, 期:9, 页:872-U8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: MUSCLE CELL-PROLIFERATION ; SPONTANEOUSLY HYPERTENSIVE RAT ; DEPENDENT KINASE INHIBITOR ; SMOOTH-MUSCLE ; GENE-THERAPY ; IN-VIVO ; CARDIOVASCULAR-DISEASE ; MITOCHONDRIAL FUSION ; INTIMAL HYPERPLASIA ; NEOINTIMA FORMATION
英文摘要:

Vascular proliferative disorders, such as atherosclerosis and restenosis, are the most common causes of severe cardiovascular diseases, but a common molecular mechanism remains elusive. Here, we identify and characterize a novel hyperplasia suppressor gene, named HSG (later re-named rat mitofusin-2). HSG expression was markedly reduced in hyper-proliferative vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rat arteries, balloon-injured Wistar Kyoto rat arteries, or ApoE-knockout mouse atherosclerotic arteries. Overexpression of HSG overtly suppressed serum-evoked VSMC proliferation in culture, and blocked balloon injury induced neointimal VSMC proliferation and restenosis in rat carotid arteries. The HSG anti-proliferative effect was mediated by inhibition of ERK/MAPK signalling and subsequent cell-cycle arrest. Deletion of the p21(ras) signature motif, but not the mitochondrial targeting domain, abolished HSG-induced growth arrest, indicating that rHSG-induced anti-proliferation was independent of mitochondrial fusion. Thus, rHSG functions as a cell proliferation suppressor, whereas dysregulation of rHSG results in proliferative disorders.

语种: 英语
WOS记录号: WOS:000223750300017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65284
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.NIA, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA
3.Peking Univ, Dept Immunol, Ctr Hlth, Beijing 100083, Peoples R China
4.Peking Univ, Inst Mol Med, Beijing 100083, Peoples R China
5.Peking Univ, Ctr Human Dis Gen, Beijing 100083, Peoples R China

Recommended Citation:
Chen, KH,Guo, XM,Ma, DL,et al. Dysregulation of HSG triggers vascular proliferative disorders[J]. NATURE CELL BIOLOGY,2004,6(9):872-U8.
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