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学科主题: 公共卫生
题名:
An accurate risk score for estimation 5-year risk of type 2 diabetes based on a health screening population in Taiwan
作者: Sun, Feng; Tao, Qiushan; Zhan, Siyan
关键词: Type 2 diabetes ; Predictive model ; Risk score ; COX model ; Risk assessment ; Cohort study
刊名: DIABETES RESEARCH AND CLINICAL PRACTICE
发表日期: 2009-08-01
DOI: 10.1016/j.diabres.2009.05.005
卷: 85, 期:2, 页:228-234
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: GLUCOSE-TOLERANCE TEST ; METABOLIC SYNDROME ; PROSPECTIVE COHORT ; FASTING GLUCOSE ; HONG-KONG ; ADULTS ; PREDICTION ; MELLITUS ; SMOKING ; INDIVIDUALS
英文摘要:

This study aimed to provide the epidemiological model evaluating the risk of developing type 2 diabetes (T2DM) in Taiwan periodic health-check population. We derived risk functions using multivariate Cox regression in a random half of the sample. Rules based on these risk functions were evaluated in another half. Model coefficients were used to assign each variable a score. 73,961 subjects aged 35-74, were included and followed up with a median 3.15 years. Six predictive models (PMs) were developed. PM1 contained simple clinical information, while PM2 contained fasting plasma glucose (FPG) based on PM1, and PM3 further added variables indicating lipid level, liver and kidney. PM4 only included FPG. The capability of published ARIC score model was also evaluated. Eventually we considered score defined nine predictors by PM2. The area under the ROC curve (AUC) was 0.848 (95% CI, 0.829-0.868) predicting diabetes within 5 years, and also had adequate performance in validation subsample (AUC = 0.833,95% CI, 0.811-0.855). The S-year T2DM probability can be calculated by: 1 - 0.9743960037 exp((score points -15.0281284)). We concluded that this diabetes risk score, derived from clinical information combined with FPG is a simple, effective tool to identify individuals at high risk for undiagnosed T2DM. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
项目资助者: MJ Health Screening Center
WOS记录号: WOS:000268655800018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65288
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Feng,Tao, Qiushan,Zhan, Siyan. An accurate risk score for estimation 5-year risk of type 2 diabetes based on a health screening population in Taiwan[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2009,85(2):228-234.
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