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A large-scale cluster randomized trial to determine the effects of community-based dietary sodium reduction-the China Rural Health Initiative Sodium Reduction Study
Li, Nicole1; Yan, Lijing L.1,2; Niu, Wenyi3; Labarthe, Darwin2; Feng, Xiangxian4; Shi, Jingpu5; Zhang, Jianxin; Zhang, Ruijuan6; Zhang, Yuhong7; Chu, Hongling1,2; Neiman, Andrea8; Engelgau, Michael9; Elliott, Paul10; Wu, Yangfeng1,2,11; Neal, Bruce12,13
刊名AMERICAN HEART JOURNAL
2013-11-01
DOI10.1016/j.ahj.2013.07.009
166期:5页:815-822
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]BLOOD-PRESSURE ; SALT ; MORTALITY
英文摘要

Background Cardiovascular diseases are the leading cause of death and disability in China. High blood pressure caused by excess intake of dietary sodium is widespread and an effective sodium reduction program has potential to improve cardiovascular health.

Design This study is a large-scale, cluster-randomized, trial done in five Northern Chinese provinces. Two counties have been selected from each province and 12 townships in each county making a total of 120 clusters. Within each township one village has been selected for participation with 1: 1 randomization stratified by county. The sodium reduction intervention comprises community health education and a food supply strategy based upon providing access to salt substitute. Subsidization of the price of salt substitute was done in 30 intervention villages selected at random. Control villages continued usual practices. The primary outcome for the study is dietary sodium intake level estimated from assays of 24-hour urine.

Trial status The trial recruited and randomized 120 townships in April 2011. The sodium reduction program was commenced in the 60 intervention villages between May and June of that year with outcome surveys scheduled for October to December 2012. Baseline data collection shows that randomisation achieved good balance across groups.

Discussion The establishment of the China Rural Health Initiative has enabled the launch of this large-scale trial designed to identify a novel, scalable strategy for reduction of dietary sodium and control of blood pressure. If proved effective, the intervention could plausibly be implemented at low cost in large parts of China and other countries worldwide.

语种英语
WOS记录号WOS:000326233500006
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65292
Collection北京大学公共卫生学院
作者单位1.Northwestern Univ, Chicago, IL 60611 USA
2.Changzhi Med Coll, Changzhi, Shanxi, Peoples R China
3.United States Ctr Dis Control, Atlanta, GA USA
4.United States Ctr Dis Control, Beijing, Peoples R China
5.China Med Univ, Hosp 1, Liaoning, Peoples R China
6.Xi An Jiao Tong Univ, Xian, Shaanxi, Peoples R China
7.Ningxia Med Univ, Ningxia, Peoples R China
8.Peking Univ, Hlth Sci Ctr, George Inst Global Hlth, Beijing 100871, Peoples R China
9.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100871, Peoples R China
10.Peking Univ, Hlth Sci Ctr, Clin Res Inst, Beijing 100871, Peoples R China
11.Univ London Imperial Coll Sci Technol & Med, London, England
12.George Inst Global Hlth, Sydney, NSW, Australia
13.Univ Sydney, Sydney, NSW 2006, Australia
Recommended Citation
GB/T 7714
Li, Nicole,Yan, Lijing L.,Niu, Wenyi,et al. A large-scale cluster randomized trial to determine the effects of community-based dietary sodium reduction-the China Rural Health Initiative Sodium Reduction Study[J]. AMERICAN HEART JOURNAL,2013,166(5):815-822.
APA Li, Nicole.,Yan, Lijing L..,Niu, Wenyi.,Labarthe, Darwin.,Feng, Xiangxian.,...&Neal, Bruce.(2013).A large-scale cluster randomized trial to determine the effects of community-based dietary sodium reduction-the China Rural Health Initiative Sodium Reduction Study.AMERICAN HEART JOURNAL,166(5),815-822.
MLA Li, Nicole,et al."A large-scale cluster randomized trial to determine the effects of community-based dietary sodium reduction-the China Rural Health Initiative Sodium Reduction Study".AMERICAN HEART JOURNAL 166.5(2013):815-822.
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