|Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy|
|Ma, Guodong1; Xu, Ming3; Gao, Wei2; Li, Zhaoping2; Li, Weihong2; Chen, Baoxia2; Feng, Jieli2; Wang, Hongyan2; Ma, Wenying1; Chen, Hui1; Shen, Aidong1; Feng, Xinheng2; Zhang, Yongzhen2|
|关键词||Tissue Doppler imaging Heart failure with normal ejection fraction Non-obstructive hypertrophic cardiomyopathy Cardiopulmonary exercise testing N-terminal pro-brain natriuretic peptide|
|刊名||BMC CARDIOVASCULAR DISORDERS|
|WOS标题词||Science & Technology|
|类目[WOS]||Cardiac & Cardiovascular Systems|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||PRESERVED EJECTION FRACTION ; CHRONIC HEART-FAILURE ; NATRIURETIC PEPTIDE ; DOPPLER-ECHOCARDIOGRAPHY ; CARDIAC-CATHETERIZATION ; VENTILATORY EFFICIENCY ; CAPACITY ; DYSFUNCTION ; RELAXATION ; PREVALENCE|
Background: Hypertrophic cardiomyopathy (HCM) patients are more susceptible to suffer from heart failure with normal ejection fraction (HFNEF). Therefore, it is critical to evaluate the relationship between left ventricular filling pressure (LVFP) and HFNEF, even if a large proportion of HCM patients have normal LVFP at rest. The objective was to assess the correlation between exercise tissue Doppler imaging (TDI) and early HFNEF in HCM patients by treadmill exercise echocardiography combined with cardiopulmonary exercise test (CPET).
Method: Twenty-seven non-obstructive HCM patients and 31 age-and gender-matched healthy volunteers were enrolled in this study. All subjects underwent treadmill exercise echocardiography combined with CPET. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were analyzed before and after exercise.
Result: Five HCM patients had normal LVFP at rest and increased after exercise. For this subgroup, the relationship between minute ventilation and carbon dioxide production (VE/VCO2 slope) and NT-proBNP levels were higher compared with controls and the subgroup with normal resting and stress LVFP, but was similar to the subgroup with elevated LVFP both at rest and after exercise.
Conclusion: Elevated LVFP after exercise suggested the occurrence of early HFNEF in patients with non-obstructive HCM.
|资助机构||National High Technology Research and Development Program of China|
|作者单位||1.Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100050, Peoples R China|
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
|Ma, Guodong,Xu, Ming,Gao, Wei,et al. Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy[J]. BMC CARDIOVASCULAR DISORDERS,2014,14.|
|APA||Ma, Guodong.,Xu, Ming.,Gao, Wei.,Li, Zhaoping.,Li, Weihong.,...&Zhang, Yongzhen.(2014).Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy.BMC CARDIOVASCULAR DISORDERS,14.|
|MLA||Ma, Guodong,et al."Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy".BMC CARDIOVASCULAR DISORDERS 14(2014).|