IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy
Ma, Guodong1; Xu, Ming3; Gao, Wei2; Li, Zhaoping2; Li, Weihong2; Chen, Baoxia2; Feng, Jieli2; Wang, Hongyan2; Ma, Wenying1; Chen, Hui1; Shen, Aidong1; Feng, Xinheng2; Zhang, Yongzhen2
关键词Tissue Doppler imaging Heart failure with normal ejection fraction Non-obstructive hypertrophic cardiomyopathy Cardiopulmonary exercise testing N-terminal pro-brain natriuretic peptide
刊名BMC CARDIOVASCULAR DISORDERS
2014-12-18
DOI10.1186/1471-2261-14-194
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者National High Technology Research and Development Program of China ; National High Technology Research and Development Program of China
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]PRESERVED EJECTION FRACTION ; CHRONIC HEART-FAILURE ; NATRIURETIC PEPTIDE ; DOPPLER-ECHOCARDIOGRAPHY ; CARDIAC-CATHETERIZATION ; VENTILATORY EFFICIENCY ; CAPACITY ; DYSFUNCTION ; RELAXATION ; PREVALENCE
英文摘要

Background: Hypertrophic cardiomyopathy (HCM) patients are more susceptible to suffer from heart failure with normal ejection fraction (HFNEF). Therefore, it is critical to evaluate the relationship between left ventricular filling pressure (LVFP) and HFNEF, even if a large proportion of HCM patients have normal LVFP at rest. The objective was to assess the correlation between exercise tissue Doppler imaging (TDI) and early HFNEF in HCM patients by treadmill exercise echocardiography combined with cardiopulmonary exercise test (CPET).

Method: Twenty-seven non-obstructive HCM patients and 31 age-and gender-matched healthy volunteers were enrolled in this study. All subjects underwent treadmill exercise echocardiography combined with CPET. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were analyzed before and after exercise.

Result: Five HCM patients had normal LVFP at rest and increased after exercise. For this subgroup, the relationship between minute ventilation and carbon dioxide production (VE/VCO2 slope) and NT-proBNP levels were higher compared with controls and the subgroup with normal resting and stress LVFP, but was similar to the subgroup with elevated LVFP both at rest and after exercise.

Conclusion: Elevated LVFP after exercise suggested the occurrence of early HFNEF in patients with non-obstructive HCM.

语种英语
所属项目编号2007AA02Z457
资助者National High Technology Research and Development Program of China ; National High Technology Research and Development Program of China
WOS记录号WOS:000347350000001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65293
Collection北京大学第三临床医学院_心血管内科
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100050, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Ma, Guodong,Xu, Ming,Gao, Wei,et al. Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy[J]. BMC CARDIOVASCULAR DISORDERS,2014,14.
APA Ma, Guodong.,Xu, Ming.,Gao, Wei.,Li, Zhaoping.,Li, Weihong.,...&Zhang, Yongzhen.(2014).Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy.BMC CARDIOVASCULAR DISORDERS,14.
MLA Ma, Guodong,et al."Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy".BMC CARDIOVASCULAR DISORDERS 14(2014).
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