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PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid
Han, Jing; Li, Li; Zhang, Zhaofeng; Xiao, Ying; Lin, Jiuxiang; Li, Yong
关键词PDGF-C all-trans retinoic acid branchial arches morphogenesis craniofacial defects
刊名TOXICOLOGY LETTERS
2006-10-25
DOI10.1016/j.toxlet.2006.07.308
166期:3页:248-254
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]GROWTH-FACTOR-C ; NEURAL CREST CELLS ; EMBRYONIC-DEVELOPMENT ; PHARYNGEAL ARCHES ; MOUSE EMBRYO ; VITAMIN-A ; IN-VITRO ; MIGRATION ; HINDBRAIN ; EXPRESSION
英文摘要

Retinoic acid (RA) is a teratogen that induces a variety of craniofacial abnormalities, including branchial arch deformities and cleft palate. Platelet-derived growth factor C (PDGF-C) is a recently identified member of the PDGF family. PDGF-C contributes to normal development of the heart, central nervous system, kidney and palatogenesis. But the roles of PDGF-C in branchial arches development and the relationship between PDGF-C and RA-induced branchial arches abnormalities are poorly understood. We examined the effects of RA on PDGF-C and its receptor PDGFR-alpha expressions. We demonstrated that administration of RA to mouse embryos resulted in dramatic losses of PDGF-C and its receptor PDGFR-alpha. Furthermore, we confirmed that blocking PDGF-C signaling by anti-PDGF-C neutralization antibody led to branchial arch malformations similar to that of RA induced, both hypoplastic branchial arches and FBA. These findings suggest the down-regulation of PDGF-C may be one of mechanisms of branchial arch abnormalities induced by RA and PDGF-C signaling is required for branchial arch morphogenesis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000241482200007
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65300
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Sci, Beijing 100083, Peoples R China
2.Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China
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Han, Jing,Li, Li,Zhang, Zhaofeng,et al. PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid[J]. TOXICOLOGY LETTERS,2006,166(3):248-254.
APA Han, Jing,Li, Li,Zhang, Zhaofeng,Xiao, Ying,Lin, Jiuxiang,&Li, Yong.(2006).PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid.TOXICOLOGY LETTERS,166(3),248-254.
MLA Han, Jing,et al."PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid".TOXICOLOGY LETTERS 166.3(2006):248-254.
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