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学科主题: 公共卫生
题名:
PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid
作者: Han, Jing; Li, Li; Zhang, Zhaofeng; Xiao, Ying; Lin, Jiuxiang; Li, Yong
关键词: PDGF-C ; all-trans retinoic acid ; branchial arches morphogenesis ; craniofacial defects
刊名: TOXICOLOGY LETTERS
发表日期: 2006-10-25
DOI: 10.1016/j.toxlet.2006.07.308
卷: 166, 期:3, 页:248-254
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: GROWTH-FACTOR-C ; NEURAL CREST CELLS ; EMBRYONIC-DEVELOPMENT ; PHARYNGEAL ARCHES ; MOUSE EMBRYO ; VITAMIN-A ; IN-VITRO ; MIGRATION ; HINDBRAIN ; EXPRESSION
英文摘要:

Retinoic acid (RA) is a teratogen that induces a variety of craniofacial abnormalities, including branchial arch deformities and cleft palate. Platelet-derived growth factor C (PDGF-C) is a recently identified member of the PDGF family. PDGF-C contributes to normal development of the heart, central nervous system, kidney and palatogenesis. But the roles of PDGF-C in branchial arches development and the relationship between PDGF-C and RA-induced branchial arches abnormalities are poorly understood. We examined the effects of RA on PDGF-C and its receptor PDGFR-alpha expressions. We demonstrated that administration of RA to mouse embryos resulted in dramatic losses of PDGF-C and its receptor PDGFR-alpha. Furthermore, we confirmed that blocking PDGF-C signaling by anti-PDGF-C neutralization antibody led to branchial arch malformations similar to that of RA induced, both hypoplastic branchial arches and FBA. These findings suggest the down-regulation of PDGF-C may be one of mechanisms of branchial arch abnormalities induced by RA and PDGF-C signaling is required for branchial arch morphogenesis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000241482200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65300
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Sci, Beijing 100083, Peoples R China
2.Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Han, Jing,Li, Li,Zhang, Zhaofeng,et al. PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid[J]. TOXICOLOGY LETTERS,2006,166(3):248-254.
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