|The Associations of Uric Acid, Cardiovascular and All-Cause Mortality in Peritoneal Dialysis Patients|
|Dong, Jie1,2,3,4; Han, Qing-Feng5; Zhu, Tong-Ying6; Ren, Ye-Ping7; Chen, Jiang-Hua; Zhao, Hui-Ping; Chen, Meng-Hua10; Xu, Rong1,2,3,4; Wang, Yue5; Hao, Chuan-Ming; Zhang, Rui7; Zhang, Xiao-Hui8; Wang, Mei9; Tian, Na10; Wang, Hai-Yan1,2,3,4|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||CHRONIC KIDNEY-DISEASE ; CORONARY-HEART-DISEASE ; RENAL-FUNCTION DECLINE ; HIGH BLOOD-PRESSURE ; HEMODIALYSIS-PATIENTS ; RISK-FACTOR ; ENDOTHELIAL DYSFUNCTION ; ATHEROSCLEROSIS RISK ; LOWERING THERAPY ; ARTERY-DISEASE|
Aims: To investigate whether uric acid (UA) is an independent predictor of cardiovascular (CV) and all-cause mortality in peritoneal dialysis (PD) patients after controlling for recognized CV risk factors.
Methods: A total of 2264 patients on chronic PD were collected from seven centers affiliated with the Socioeconomic Status on the Outcome of Peritoneal Dialysis (SSOP) Study. All demographic and laboratory data were recorded at baseline. Multivariate Cox regression was used to calculate the hazard ratio (HR) of CV and all-cause mortality with adjustments for recognized traditional and uremia-related CV factors.
Results: There were no significant differences in baseline characteristics between patients with (n = 2193) and without (n = 71) UA measured. Each 1 mg/dL of increase in UA was associated with higher all-cause mortality with 1.05(1.00 similar to 1.10) of HR and higher CV mortality with 1.12 (1.05 similar to 1.20) of HR after adjusting for age, gender and center size. The highest gender-specific tertile of UA predicted higher all-cause mortality with 1.23(1.00 similar to 1.52) of HR and higher CV mortality with 1.69 (1.21 similar to 2.38) of HR after adjusting for age, gender and center size. The predictive value of UA was stronger in patients younger than 65 years without CV disease or diabetes at baseline. The prognostic value of UA as both continuous and categorical variable weakened or disappeared after further adjusted for uremia-related and traditional CV risk factors.
Conclusions: The prognostic value of UA in CV and all-cause mortality was weak in PD patients generally, which was confounded by uremia-related and traditional CV risk factors.
|资助机构||Education Department, China ; Baxer Clinical Research Award from Baxter Corp, China ; ISN Research Award from the ISN GO RP Committee|
|作者单位||1.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100871, Peoples R China|
2.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100871, Peoples R China
3.Fudan Univ, Dept Nephrol, Huashan Hosp, Shanghai 200433, Peoples R China
4.Harbin Med Univ, Dept Nephrol, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China
5.Zhejiang Univ, Affiliated Hosp 1, Kidney Dis Ctr, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
6.Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100871, Peoples R China
7.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
8.Minist Hlth, Key Lab Renal Dis, Beijing, Peoples R China
9.Minist Educ, Key Lab Renal Dis, Beijing, Peoples R China
10.Ningxia Med Univ, Gen Hosp, Dept Nephrol, Ningxia, Peoples R China
|Dong, Jie,Han, Qing-Feng,Zhu, Tong-Ying,et al. The Associations of Uric Acid, Cardiovascular and All-Cause Mortality in Peritoneal Dialysis Patients[J]. PLOS ONE,2014,9(1).|
|APA||Dong, Jie.,Han, Qing-Feng.,Zhu, Tong-Ying.,Ren, Ye-Ping.,Chen, Jiang-Hua.,...&Wang, Hai-Yan.(2014).The Associations of Uric Acid, Cardiovascular and All-Cause Mortality in Peritoneal Dialysis Patients.PLOS ONE,9(1).|
|MLA||Dong, Jie,et al."The Associations of Uric Acid, Cardiovascular and All-Cause Mortality in Peritoneal Dialysis Patients".PLOS ONE 9.1(2014).|