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学科主题临床医学
Association between Helicobacter pylori infection and colorectal neoplasm risk: A meta-analysis Based on East Asian population
Guo, Yu1; Li, Hai-Yan2
关键词Colorectal neoplasm Helicobacter pylori infection meta-analysis risk
刊名JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
2014-12-01
DOI10.4103/0973-1482.151482
suppl.4期:8页:C263-C266
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CANCER ; INCREASES ; POLYPS
英文摘要

Objective: The association between Helicobacter pylori (HP) infection and colorectal neoplasm risk was not clear. The aim of this study was to evaluate whether HP infection can increase the risk of developing colorectal neoplasm by meta-analysis.

Materials and Methods: A detailed literature search was performed on Medline, PubMed, Web of Science, and China National Knowledge Infrastructure for related research publications written in English and/or Chinese. The relevant case-control or cohort studies reporting an association between HP infection and colorectal neoplasm risk were screened and included in this meta-analysis. The association between HP infection and colorectal neoplasm risk was expressed by odds ratio (OR) and its 95% confidence interval (CI). The heterogeneity among the included articles was assessed by I-2 test, and the pooled OR was calculated by fixed effect model in case of no significant heterogeneity otherwise random effect model was employed. All the statistical analyses were done by STATA-11.0 and MetaAnalyst Beta 3.13 software.

Results: Finally, a total of 2081 colorectal neoplasm patients and 5598 healthy controls from nine eligible studies were included in this meta-analysis. The pooled OR for the association between HP infection and colorectal neoplasm risk was 0.18 with its 95% CI of 0.99-1.40, (P > 0.05). We further divided the colorectal neoplasm into the hyperplastic polyps, adenomas and colorectal cancer sub-groups according to colorectal neoplasm types. The pooled ORs and their 95% CIs were ORHyperplastic_polyps = 0.72, 95% CI: 0.44-1.18, (P > 0.05), OR A(denomas) = 1.83, 95% CI: 1.35-2.51, (P < 0.01), ORColorectal_cancer = 1.08, 95% CI: 0.89-1.68 (P > 0.05). For different region sub-groups, the pooled ORs and 95% CIs were ORSouth_Korea = 1.18, 95% CI: 0.84-1.66, (P > 0.05), ORChina = 0.78, 95% CI: 0.53-1.13, (P > 0.05), ORTaiwan = 1.06, 95% CI: 0.69-1.62, (P > 0.05), ORJapan = 1.33, 95% CI: 1.07-1.65, (P < 0.05) for South Korea, China main land, Taiwan and Japanese.

Conclusion: In general, no statistical association between HP infection and colorectal neoplasm risk was found in this meta-analysis. But, HP infection may increase the risk of developing colorectal adenomas.

语种英语
WOS记录号WOS:000355249800007
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65317
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
2.Beijing Chuiyangliu Hosp, Dept Clin Lab, Beijing 100022, Peoples R China
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GB/T 7714
Guo, Yu,Li, Hai-Yan. Association between Helicobacter pylori infection and colorectal neoplasm risk: A meta-analysis Based on East Asian population[J]. JOURNAL OF CANCER RESEARCH AND THERAPEUTICS,2014,suppl.4(8):C263-C266.
APA Guo, Yu,&Li, Hai-Yan.(2014).Association between Helicobacter pylori infection and colorectal neoplasm risk: A meta-analysis Based on East Asian population.JOURNAL OF CANCER RESEARCH AND THERAPEUTICS,suppl.4(8),C263-C266.
MLA Guo, Yu,et al."Association between Helicobacter pylori infection and colorectal neoplasm risk: A meta-analysis Based on East Asian population".JOURNAL OF CANCER RESEARCH AND THERAPEUTICS suppl.4.8(2014):C263-C266.
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