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学科主题: 精神卫生
题名:
Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder
作者: Fang, Yantong1; Ji, Ning2,3; Cao, Qingjiu2,3; Su, Yi2,3; Chen, Min2,3; Wang, Yufeng2,3; Yang, Li2,3
刊名: JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
发表日期: 2015-10-01
DOI: 10.1089/cap.2014.0178
卷: 25, 期:8, 页:625-632
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pediatrics ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: DEFICIT HYPERACTIVITY DISORDER ; NOREPINEPHRINE TRANSPORTER GENE ; METHYLPHENIDATE DOSE-RESPONSE ; GENOME-WIDE ASSOCIATION ; CLINICAL-RESPONSE ; RECEPTOR GENE ; DOUBLE-BLIND ; ADHD ; POLYMORPHISM ; DAT1
英文摘要:

Objective: Atomoxetine is the most widely used nonstimulant for the treatment of attention-deficit/hyperactivity disorder (ADHD). It selectively acts on the norepinephrine (NE) system. Dopamine beta hydroxylase (DBH) regulates the synthesis of NE. This study aimed to investigate whether variants in the DBH gene have an effect on the differential response to atomoxetine. Methods: Children and adolescents with ADHD were enrolled in a prospective, open-label study of atomoxetine for 8-12 weeks. The dose was titrated to 1.2-1.4mg/kg per day and maintained for at least 4 weeks. The primary efficacy measure was the investigator-rated ADHD Rating Scale-IV (ADHD-RS-IV). Three categorical evaluations of treatment effects (defined as response, robust response, and remission) were used. We used a candidate gene approach. Eight single nucleotide polymorphisms (SNPs) in DBH were selected and genotyped based on the functional annotation in literature. Their association with response or remission status was analyzed. Results: Four SNPs were found nominally associated with response status (rs1076150, p=0.0484; rs2873804, p=0.0348; rs1548364, p=0.0383; and rs2519154, p=0.0097), two were associated with robust response (rs1076150, p=0.0349; and rs2519154, p=0.0047), and one was associated with remission (rs2519154, p=0.0479). The association between rs2519154 and robust response was significant after correction of multiple comparison (p=0.0384). Two haplotypes of linkage disequilibrium (LD) block1 (constituted by rs1108580, rs2873804, rs1548364, and rs2519154) were nominally associated with response and robust response status (CTAC: p=0.0301 for response, p=0.0374 for robust response; TCGT: p=0.0317 for response, p=0.021 for robust response), whereas one haplotype (GC) of LD block2 (constituted by rs2073837 and rs129882) was associated with robust response and remission status (p=0.0377 for robust response; p=0.0321 for remission), although none achieved significant threshold after multiple comparison. Conclusions: Variants in DBH genes were associated with atomoxetine response in the treatment of ADHD. Further replication in larger samples would be warranted.

语种: 英语
所属项目编号: 81471381 ; 81201059 ; 2014CB846100 ; 2011-4024-04 ; 2015BAI13B01
项目资助者: National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Capital Health Development Research Fund ; National Key Technology Research and Development Program of the Ministry of Science and Technology of China
WOS记录号: WOS:000363884700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65326
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou, Zhejiang, Peoples R China
2.Beijing Univ, Hosp 6, Inst Mental Hlth, Key Lab Mental Hlth,Minist Hlth, Beijing 100871, Peoples R China
3.Beijing Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Beijing 100871, Peoples R China

Recommended Citation:
Fang, Yantong,Ji, Ning,Cao, Qingjiu,et al. Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder[J]. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY,2015,25(8):625-632.
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