IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder
Fang, Yantong1; Ji, Ning2,3; Cao, Qingjiu2,3; Su, Yi2,3; Chen, Min2,3; Wang, Yufeng2,3; Yang, Li2,3
刊名JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
2015-10-01
DOI10.1089/cap.2014.0178
25期:8页:625-632
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Pediatrics ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; NOREPINEPHRINE TRANSPORTER GENE ; METHYLPHENIDATE DOSE-RESPONSE ; GENOME-WIDE ASSOCIATION ; CLINICAL-RESPONSE ; RECEPTOR GENE ; DOUBLE-BLIND ; ADHD ; POLYMORPHISM ; DAT1
英文摘要

Objective: Atomoxetine is the most widely used nonstimulant for the treatment of attention-deficit/hyperactivity disorder (ADHD). It selectively acts on the norepinephrine (NE) system. Dopamine beta hydroxylase (DBH) regulates the synthesis of NE. This study aimed to investigate whether variants in the DBH gene have an effect on the differential response to atomoxetine. Methods: Children and adolescents with ADHD were enrolled in a prospective, open-label study of atomoxetine for 8-12 weeks. The dose was titrated to 1.2-1.4mg/kg per day and maintained for at least 4 weeks. The primary efficacy measure was the investigator-rated ADHD Rating Scale-IV (ADHD-RS-IV). Three categorical evaluations of treatment effects (defined as response, robust response, and remission) were used. We used a candidate gene approach. Eight single nucleotide polymorphisms (SNPs) in DBH were selected and genotyped based on the functional annotation in literature. Their association with response or remission status was analyzed. Results: Four SNPs were found nominally associated with response status (rs1076150, p=0.0484; rs2873804, p=0.0348; rs1548364, p=0.0383; and rs2519154, p=0.0097), two were associated with robust response (rs1076150, p=0.0349; and rs2519154, p=0.0047), and one was associated with remission (rs2519154, p=0.0479). The association between rs2519154 and robust response was significant after correction of multiple comparison (p=0.0384). Two haplotypes of linkage disequilibrium (LD) block1 (constituted by rs1108580, rs2873804, rs1548364, and rs2519154) were nominally associated with response and robust response status (CTAC: p=0.0301 for response, p=0.0374 for robust response; TCGT: p=0.0317 for response, p=0.021 for robust response), whereas one haplotype (GC) of LD block2 (constituted by rs2073837 and rs129882) was associated with robust response and remission status (p=0.0377 for robust response; p=0.0321 for remission), although none achieved significant threshold after multiple comparison. Conclusions: Variants in DBH genes were associated with atomoxetine response in the treatment of ADHD. Further replication in larger samples would be warranted.

语种英语
WOS记录号WOS:000363884700005
项目编号81471381 ; 81201059 ; 2014CB846100 ; 2011-4024-04 ; 2015BAI13B01
资助机构National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Capital Health Development Research Fund ; National Key Technology Research and Development Program of the Ministry of Science and Technology of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65326
专题北京大学精神卫生研究所
北京大学第一临床医学院_肾脏内科
北京大学精神卫生研究所_精神科
作者单位1.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou, Zhejiang, Peoples R China
2.Beijing Univ, Hosp 6, Inst Mental Hlth, Key Lab Mental Hlth,Minist Hlth, Beijing 100871, Peoples R China
3.Beijing Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Fang, Yantong,Ji, Ning,Cao, Qingjiu,et al. Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder[J]. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY,2015,25(8):625-632.
APA Fang, Yantong.,Ji, Ning.,Cao, Qingjiu.,Su, Yi.,Chen, Min.,...&Yang, Li.(2015).Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder.JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY,25(8),625-632.
MLA Fang, Yantong,et al."Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder".JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY 25.8(2015):625-632.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fang, Yantong]的文章
[Ji, Ning]的文章
[Cao, Qingjiu]的文章
百度学术
百度学术中相似的文章
[Fang, Yantong]的文章
[Ji, Ning]的文章
[Cao, Qingjiu]的文章
必应学术
必应学术中相似的文章
[Fang, Yantong]的文章
[Ji, Ning]的文章
[Cao, Qingjiu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。