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Design, Synthesis and Activities of Aziridine Derivatives of N-5-Methyltetrahydrofolate Against Methionine Synthase
Deng Xiling1,3; Guo Ying1; Tian Chao1; Liu Junyi1,2; Wang Xiaowei1; Zhang Zhili1
关键词Aziridine Methionine synthase Ring closure reaction N-5-Methyltetrahydrofolate
刊名CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
2015-10-01
DOI10.1007/s40242-015-5194-z
31期:5页:742-745
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
英文摘要

Aziridine derivatives of N-5-methyltetrahydrofolate were designed and synthesized based on the mechanism of methionine synthase, and their biological activities were investigated as well. The aziridine derivatives 1 and 6 exhibited superior inhibitory activities(IC50: 5.05 and 4.15 mu mol/L, respectively) compared to the corresponding chain analogue 4(IC50=-24.42 mu mol). The results suggest that the aziridine derivatives can get potential activities against nucleophilic methionine synthase.

语种英语
WOS记录号WOS:000362860000012
项目编号21172014
资助机构National Natural Science Foundation of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65329
专题北京大学药学院_化学生物学系
北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Shihezi Univ, Sch Pharmaceut Sci, Shihezi 832000, Peoples R China
推荐引用方式
GB/T 7714
Deng Xiling,Guo Ying,Tian Chao,et al. Design, Synthesis and Activities of Aziridine Derivatives of N-5-Methyltetrahydrofolate Against Methionine Synthase[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2015,31(5):742-745.
APA Deng Xiling,Guo Ying,Tian Chao,Liu Junyi,Wang Xiaowei,&Zhang Zhili.(2015).Design, Synthesis and Activities of Aziridine Derivatives of N-5-Methyltetrahydrofolate Against Methionine Synthase.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,31(5),742-745.
MLA Deng Xiling,et al."Design, Synthesis and Activities of Aziridine Derivatives of N-5-Methyltetrahydrofolate Against Methionine Synthase".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 31.5(2015):742-745.
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