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学科主题: 药学
题名:
Design, Synthesis and Activities of Aziridine Derivatives of N-5-Methyltetrahydrofolate Against Methionine Synthase
作者: Deng Xiling1,3; Guo Ying1; Tian Chao1; Liu Junyi1,2; Wang Xiaowei1; Zhang Zhili1
关键词: Aziridine ; Methionine synthase ; Ring closure reaction ; N-5-Methyltetrahydrofolate
刊名: CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
发表日期: 2015-10-01
DOI: 10.1007/s40242-015-5194-z
卷: 31, 期:5, 页:742-745
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要:

Aziridine derivatives of N-5-methyltetrahydrofolate were designed and synthesized based on the mechanism of methionine synthase, and their biological activities were investigated as well. The aziridine derivatives 1 and 6 exhibited superior inhibitory activities(IC50: 5.05 and 4.15 mu mol/L, respectively) compared to the corresponding chain analogue 4(IC50=-24.42 mu mol). The results suggest that the aziridine derivatives can get potential activities against nucleophilic methionine synthase.

语种: 英语
所属项目编号: 21172014
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000362860000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65329
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Shihezi Univ, Sch Pharmaceut Sci, Shihezi 832000, Peoples R China

Recommended Citation:
Deng Xiling,Guo Ying,Tian Chao,et al. Design, Synthesis and Activities of Aziridine Derivatives of N-5-Methyltetrahydrofolate Against Methionine Synthase[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2015,31(5):742-745.
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