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学科主题: 药物依赖
题名:
Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats
作者: Liu, Qing1; Qin, Wangjun1; Zhang, Min1; Wang, Yanting1; Jing, Li1,2; Li, Junxu3; Liang, Jianhui1
关键词: frustration ; morphine ; sucrose reward deprivation ; T-maze ; naloxone
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2011-11-21
DOI: 10.3969/j.issn.1673-5374.2011.28.009
卷: 6, 期:28, 页:2211-2216
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: MICE ; REINFORCEMENT ; DRUGS
英文摘要:

In this study, a T-maze-based frustration model in rats was established using sucrose-reward deprivation. The results revealed that rats maintained a 75% preference for the sucrose-reward arm in the reward phase. During the sucrose-deprivation frustration phase, both the preference for the sucrose-deprivation arm (62.5%) and time spent waiting in the sucrose-deprivation arm decreased. Acute injection of morphine increased the preference in a dose-dependent fashion, and prolonged the waiting duration in the sucrose-deprivation arm. These findings indicate that morphine specifically inhibited the frustration response induced by sucrose reward deprivation. To further elucidate the pharmacological mechanisms involved, the opioid receptor antagonist naloxone was given to model rats prior to the injection of morphine. The results revealed that naloxone administration markedly attenuated the anti-frustration-like effects of 3 mg/kg morphine treatment. These findings suggest that morphine attenuates the frustration-like response to reward deprivation in rats through the opioid receptor.

语种: 英语
所属项目编号: 30870894 ; 2009CB522000 ; 2011BAK04B08
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China ; National Key Technology R&amp ; D Program of China
WOS记录号: WOS:000297305200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65332
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Tianjin Med Univ, Dept Physiol, Tianjin 300070, Peoples R China
3.SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA

Recommended Citation:
Liu, Qing,Qin, Wangjun,Zhang, Min,et al. Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats[J]. NEURAL REGENERATION RESEARCH,2011,6(28):2211-2216.
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