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Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats
Liu, Qing1; Qin, Wangjun1; Zhang, Min1; Wang, Yanting1; Jing, Li1,2; Li, Junxu3; Liang, Jianhui1
关键词frustration morphine sucrose reward deprivation T-maze naloxone
刊名NEURAL REGENERATION RESEARCH
2011-11-21
DOI10.3969/j.issn.1673-5374.2011.28.009
6期:28页:2211-2216
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]MICE ; REINFORCEMENT ; DRUGS
英文摘要

In this study, a T-maze-based frustration model in rats was established using sucrose-reward deprivation. The results revealed that rats maintained a 75% preference for the sucrose-reward arm in the reward phase. During the sucrose-deprivation frustration phase, both the preference for the sucrose-deprivation arm (62.5%) and time spent waiting in the sucrose-deprivation arm decreased. Acute injection of morphine increased the preference in a dose-dependent fashion, and prolonged the waiting duration in the sucrose-deprivation arm. These findings indicate that morphine specifically inhibited the frustration response induced by sucrose reward deprivation. To further elucidate the pharmacological mechanisms involved, the opioid receptor antagonist naloxone was given to model rats prior to the injection of morphine. The results revealed that naloxone administration markedly attenuated the anti-frustration-like effects of 3 mg/kg morphine treatment. These findings suggest that morphine attenuates the frustration-like response to reward deprivation in rats through the opioid receptor.

语种英语
WOS记录号WOS:000297305200009
项目编号30870894 ; 2009CB522000 ; 2011BAK04B08
资助机构National Natural Science Foundation of China ; National Basic Research Program of China ; National Key Technology R&amp ; D Program of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65332
专题中国药物依赖性研究所
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Tianjin Med Univ, Dept Physiol, Tianjin 300070, Peoples R China
3.SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA
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GB/T 7714
Liu, Qing,Qin, Wangjun,Zhang, Min,et al. Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats[J]. NEURAL REGENERATION RESEARCH,2011,6(28):2211-2216.
APA Liu, Qing.,Qin, Wangjun.,Zhang, Min.,Wang, Yanting.,Jing, Li.,...&Liang, Jianhui.(2011).Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats.NEURAL REGENERATION RESEARCH,6(28),2211-2216.
MLA Liu, Qing,et al."Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats".NEURAL REGENERATION RESEARCH 6.28(2011):2211-2216.
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