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学科主题: 临床医学
题名:
Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure
作者: Liu, H.1; Zhang, H.1,2; Wan, G.1; Sang, Y.1; Chang, Y.1; Wang, X.1; Zeng, H.1,3,4
关键词: hepatitis B virus-related-acute-on-chronic liver failure ; lymphocytes ; neutrophil ; prognosis
刊名: JOURNAL OF VIRAL HEPATITIS
发表日期: 2014-07-01
DOI: 10.1111/jvh.12160
卷: 21, 期:7, 页:499-507
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]: PLASMA-EXCHANGE TREATMENT ; DISEASE SCORING SYSTEM ; OXIDATIVE STRESS ; VIRUS INFECTION ; T-CELLS ; INJURY ; MODEL ; INFLAMMATION ; SEVERITY ; PRODUCTS
英文摘要:

Acute-on-chronic hepatitis B liver failure (ACH-BLF) has a poor prognosis in patients with hepatitis B virus infection. The role of the neutrophil-lymphocyte ratio (NLR), which reflects the inflammatory status of the patient before treatment, has never been studied in this setting. To investigate the predictive value of NLR in patients with ACHBLF, a retrospective cohort with 216 patients and a prospective validation cohort with 73 patients were recruited. Multivariate analyses showed that total bilirubin (TBIL), NLR, age and model for end-stage liver disease (MELD) score had prognostic significance for survival. Both NLR (0.781) and MELD score (0.744) had higher ROC curves, which differed significantly from those for age (0.615) and TBIL (0.691), but not from each other (P = 0.94). NLR <= 2.36 predicted lower mortality (with 91.6% sensitivity and 86.0% negative predictive value), and NLR >6.12 was a warning sign for higher mortality risk (with 90.1% specificity and 80.3% positive predictive value). These results demonstrated that pretreatment NLR was associated with the prognosis of patients with ACHBLF, and elevated NLR predicted poor outcome within 8 weeks. We suggest that NLR cut-offs of <= 2.36 and >6.12 are powerful markers for predicting mortality in ACHBLF.

语种: 英语
所属项目编号: 81072766 ; Z111107056811044 ; 2009-2-13
项目资助者: National Science Foundation of China grant ; Beijing Technology Discipline Project ; 215 program
WOS记录号: WOS:000337695800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65333
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Ditan Hosp, Beijing 100015, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100871, Peoples R China
3.Capital Med Univ, Inst Infect Dis, Beijing 100015, Peoples R China
4.Beijing Key Lab Emerging Infect Dis, Beijing, Peoples R China

Recommended Citation:
Liu, H.,Zhang, H.,Wan, G.,et al. Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure[J]. JOURNAL OF VIRAL HEPATITIS,2014,21(7):499-507.
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