学科主题临床医学
Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure
Liu, H.1; Zhang, H.1,2; Wan, G.1; Sang, Y.1; Chang, Y.1; Wang, X.1; Zeng, H.1,3,4
关键词hepatitis B virus-related-acute-on-chronic liver failure lymphocytes neutrophil prognosis
刊名JOURNAL OF VIRAL HEPATITIS
2014-07-01
DOI10.1111/jvh.12160
21期:7页:499-507
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]PLASMA-EXCHANGE TREATMENT ; DISEASE SCORING SYSTEM ; OXIDATIVE STRESS ; VIRUS INFECTION ; T-CELLS ; INJURY ; MODEL ; INFLAMMATION ; SEVERITY ; PRODUCTS
英文摘要

Acute-on-chronic hepatitis B liver failure (ACH-BLF) has a poor prognosis in patients with hepatitis B virus infection. The role of the neutrophil-lymphocyte ratio (NLR), which reflects the inflammatory status of the patient before treatment, has never been studied in this setting. To investigate the predictive value of NLR in patients with ACHBLF, a retrospective cohort with 216 patients and a prospective validation cohort with 73 patients were recruited. Multivariate analyses showed that total bilirubin (TBIL), NLR, age and model for end-stage liver disease (MELD) score had prognostic significance for survival. Both NLR (0.781) and MELD score (0.744) had higher ROC curves, which differed significantly from those for age (0.615) and TBIL (0.691), but not from each other (P = 0.94). NLR <= 2.36 predicted lower mortality (with 91.6% sensitivity and 86.0% negative predictive value), and NLR >6.12 was a warning sign for higher mortality risk (with 90.1% specificity and 80.3% positive predictive value). These results demonstrated that pretreatment NLR was associated with the prognosis of patients with ACHBLF, and elevated NLR predicted poor outcome within 8 weeks. We suggest that NLR cut-offs of <= 2.36 and >6.12 are powerful markers for predicting mortality in ACHBLF.

语种英语
WOS记录号WOS:000337695800012
项目编号81072766 ; Z111107056811044 ; 2009-2-13
资助机构National Science Foundation of China grant ; Beijing Technology Discipline Project ; 215 program
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65333
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Capital Med Univ, Beijing Ditan Hosp, Beijing 100015, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100871, Peoples R China
3.Capital Med Univ, Inst Infect Dis, Beijing 100015, Peoples R China
4.Beijing Key Lab Emerging Infect Dis, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liu, H.,Zhang, H.,Wan, G.,et al. Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure[J]. JOURNAL OF VIRAL HEPATITIS,2014,21(7):499-507.
APA Liu, H..,Zhang, H..,Wan, G..,Sang, Y..,Chang, Y..,...&Zeng, H..(2014).Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure.JOURNAL OF VIRAL HEPATITIS,21(7),499-507.
MLA Liu, H.,et al."Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure".JOURNAL OF VIRAL HEPATITIS 21.7(2014):499-507.
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