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学科主题: 基础医学
题名:
PLAC1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients
作者: Dong, Xue-Yuan1; Peng, Ji-Run2; Ye, Ying-Jian5; Chen, Hong-Song3; Zhan, Li-Jie1; Pang, Xue-Wen1; Li, Yan1; Zhang, Yu1; Wang, Shan5; Fant, Michael E.4; Yin, Yan-Hui1; Chen, Wei-Feng1
关键词: PLAC1 ; tumor-specific antigen ; SSH analysis ; hepatocellular carcinoma ; cancer/testis antigen
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2008-05-01
DOI: 10.1002/ijc.23341
卷: 122, 期:9, 页:2038-2043
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SUPPRESSION SUBTRACTIVE HYBRIDIZATION ; HUMAN HEPATOCELLULAR-CARCINOMA ; ISCOMATRIX ADJUVANT ; MESSENGER-RNA ; GENE CAGE ; ES CELLS ; EXPRESSION ; IDENTIFICATION ; PLACENTA ; PROTEIN
英文摘要:

Immunoselection and tumor evasion constitutes one of the major obstacles in cancer immunotherapy. A potential solution to this problem is the development of polyvalent vaccines, and the identification of more tumor-specific antigens is a prerequisite for the development of cancer vaccines. To identify novel tumor-specific antigens, suppression subtractive hybridization (SSH) was performed to isolate genes differentially expressed in human hepatocellular cancer (HCC) tissues. PLAC1 (PLACenta-specific 1) was one of the genes identified highly expressed in HCC tissues but not in paired noncancerous tissues. Further analyses revealed its expression in several other types of cancer tissues as well as tumor cell lines, but not in normal tissues except for placenta. Among HCC samples tested, 32% (22/69) showed PLAC1 mRNA expression while the protein was detected in 23.3% (7/30). A serological survey revealed that 3.8% (4/101) of HCC patients had anti-PLAC1 antibody response, suggesting the immunogenicity of PLAC1 in HCC patients. PLAC1 represents a new class of tumor associated antigen with restricted expression in placenta and cancer tissues, that may serve as a target for cancer vaccination. (C) 2008 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000254224100016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65344
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Peoples Hosp, Ctr Hepatobiol Surg, Beijing 100083, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100083, Peoples R China
4.Univ Texas Houston, Hlth Sci Ctr, Dept Pediat, Houston, TX 77225 USA
5.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100083, Peoples R China

Recommended Citation:
Dong, Xue-Yuan,Peng, Ji-Run,Ye, Ying-Jian,et al. PLAC1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients[J]. INTERNATIONAL JOURNAL OF CANCER,2008,122(9):2038-2043.
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