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学科主题基础医学
PLAC1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients
Dong, Xue-Yuan1; Peng, Ji-Run2; Ye, Ying-Jian5; Chen, Hong-Song3; Zhan, Li-Jie1; Pang, Xue-Wen1; Li, Yan1; Zhang, Yu1; Wang, Shan5; Fant, Michael E.4; Yin, Yan-Hui1; Chen, Wei-Feng1
关键词PLAC1 tumor-specific antigen SSH analysis hepatocellular carcinoma cancer/testis antigen
刊名INTERNATIONAL JOURNAL OF CANCER
2008-05-01
DOI10.1002/ijc.23341
122期:9页:2038-2043
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SUPPRESSION SUBTRACTIVE HYBRIDIZATION ; HUMAN HEPATOCELLULAR-CARCINOMA ; ISCOMATRIX ADJUVANT ; MESSENGER-RNA ; GENE CAGE ; ES CELLS ; EXPRESSION ; IDENTIFICATION ; PLACENTA ; PROTEIN
英文摘要

Immunoselection and tumor evasion constitutes one of the major obstacles in cancer immunotherapy. A potential solution to this problem is the development of polyvalent vaccines, and the identification of more tumor-specific antigens is a prerequisite for the development of cancer vaccines. To identify novel tumor-specific antigens, suppression subtractive hybridization (SSH) was performed to isolate genes differentially expressed in human hepatocellular cancer (HCC) tissues. PLAC1 (PLACenta-specific 1) was one of the genes identified highly expressed in HCC tissues but not in paired noncancerous tissues. Further analyses revealed its expression in several other types of cancer tissues as well as tumor cell lines, but not in normal tissues except for placenta. Among HCC samples tested, 32% (22/69) showed PLAC1 mRNA expression while the protein was detected in 23.3% (7/30). A serological survey revealed that 3.8% (4/101) of HCC patients had anti-PLAC1 antibody response, suggesting the immunogenicity of PLAC1 in HCC patients. PLAC1 represents a new class of tumor associated antigen with restricted expression in placenta and cancer tissues, that may serve as a target for cancer vaccination. (C) 2008 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000254224100016
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/65344
专题北京大学基础医学院_免疫学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Peoples Hosp, Ctr Hepatobiol Surg, Beijing 100083, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100083, Peoples R China
4.Univ Texas Houston, Hlth Sci Ctr, Dept Pediat, Houston, TX 77225 USA
5.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100083, Peoples R China
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Dong, Xue-Yuan,Peng, Ji-Run,Ye, Ying-Jian,et al. PLAC1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients[J]. INTERNATIONAL JOURNAL OF CANCER,2008,122(9):2038-2043.
APA Dong, Xue-Yuan.,Peng, Ji-Run.,Ye, Ying-Jian.,Chen, Hong-Song.,Zhan, Li-Jie.,...&Chen, Wei-Feng.(2008).PLAC1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients.INTERNATIONAL JOURNAL OF CANCER,122(9),2038-2043.
MLA Dong, Xue-Yuan,et al."PLAC1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients".INTERNATIONAL JOURNAL OF CANCER 122.9(2008):2038-2043.
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