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学科主题: 基础医学
题名:
Peripheral electrical stimulation-induced suppression of morphine-induced CCP in rats: A role for dopamine in the nucleus accumbens
作者: Ma, Yao-Ying1,2,3,4,5; Shi, Xiang-Dang1,2,3,4; Han, Ji-Sheng1,2,3,4; Cui, Cai-Lian1,2,3,4
关键词: conditioned place preference ; mesolimbic dopamine system ; peripheral electric stimulation ; morphine ; rat
刊名: BRAIN RESEARCH
发表日期: 2008-05-30
DOI: 10.1016/j.brainres.2008.03.044
卷: 1212, 期:1212, 页:63-70
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; DYNORPHIN A-(1-13) ; INDUCED AMNESIA ; 2 HZ ; NMDA RECEPTOR ; MICE ; COCAINE ; REINSTATEMENT ; WITHDRAWAL ; MEMORY
英文摘要:

In the previous study we reported that morphine-induced conditioned place preference (CPP) could be suppressed by peripheral electric stimulation (PES), an effect related to the increased gene expression of opioid peptides in the central nervous system. Considering that opioids were known to elevate dopamine (DA) activity in the mesolimbic brain, the present study was designed to further analyze the possible involvement of the mesolimbic dopaminergic system (MLDS) in the suppressive effect of PES on the rewarding effects of morphine in SD male rats. We found that morphine-induced CPP can be successfully suppressed by PES, an effect accompanied by a reversal of the increased tissue contents of DA and its metabolites in the nucleus accumbens (NAc) of morphine-induced CPP rats. Our results suggest that MLDS seems to play important roles in the mechanisms underlying PES′s suppression of the rewarding effect of drug-associated environmental cues in the rat. (c) 2008 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000257050100008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65346
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100083, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China
4.Minist Publ Hlth, Key Lab Neurosci, Beijing 100083, Peoples R China
5.Harvard Univ, McLean Hosp, Sch Med, Alternat Med Ctr, Belmont, MA 02478 USA

Recommended Citation:
Ma, Yao-Ying,Shi, Xiang-Dang,Han, Ji-Sheng,et al. Peripheral electrical stimulation-induced suppression of morphine-induced CCP in rats: A role for dopamine in the nucleus accumbens[J]. BRAIN RESEARCH,2008,1212(1212):63-70.
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