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学科主题基础医学
Peripheral electrical stimulation-induced suppression of morphine-induced CCP in rats: A role for dopamine in the nucleus accumbens
Ma, Yao-Ying1,2,3,4,5; Shi, Xiang-Dang1,2,3,4; Han, Ji-Sheng1,2,3,4; Cui, Cai-Lian1,2,3,4
关键词Conditioned Place Preference Mesolimbic Dopamine System Peripheral Electric Stimulation Morphine Rat
刊名BRAIN RESEARCH
2008-05-30
DOI10.1016/j.brainres.2008.03.044
1212期:1212页:63-70
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CONDITIONED PLACE PREFERENCE ; DYNORPHIN A-(1-13) ; INDUCED AMNESIA ; 2 HZ ; NMDA RECEPTOR ; MICE ; COCAINE ; REINSTATEMENT ; WITHDRAWAL ; MEMORY
英文摘要

In the previous study we reported that morphine-induced conditioned place preference (CPP) could be suppressed by peripheral electric stimulation (PES), an effect related to the increased gene expression of opioid peptides in the central nervous system. Considering that opioids were known to elevate dopamine (DA) activity in the mesolimbic brain, the present study was designed to further analyze the possible involvement of the mesolimbic dopaminergic system (MLDS) in the suppressive effect of PES on the rewarding effects of morphine in SD male rats. We found that morphine-induced CPP can be successfully suppressed by PES, an effect accompanied by a reversal of the increased tissue contents of DA and its metabolites in the nucleus accumbens (NAc) of morphine-induced CPP rats. Our results suggest that MLDS seems to play important roles in the mechanisms underlying PES′s suppression of the rewarding effect of drug-associated environmental cues in the rat. (c) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000257050100008
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65346
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100083, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing 100083, Peoples R China
4.Minist Publ Hlth, Key Lab Neurosci, Beijing 100083, Peoples R China
5.Harvard Univ, McLean Hosp, Sch Med, Alternat Med Ctr, Belmont, MA 02478 USA
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GB/T 7714
Ma, Yao-Ying,Shi, Xiang-Dang,Han, Ji-Sheng,et al. Peripheral electrical stimulation-induced suppression of morphine-induced CCP in rats: A role for dopamine in the nucleus accumbens[J]. BRAIN RESEARCH,2008,1212(1212):63-70.
APA Ma, Yao-Ying,Shi, Xiang-Dang,Han, Ji-Sheng,&Cui, Cai-Lian.(2008).Peripheral electrical stimulation-induced suppression of morphine-induced CCP in rats: A role for dopamine in the nucleus accumbens.BRAIN RESEARCH,1212(1212),63-70.
MLA Ma, Yao-Ying,et al."Peripheral electrical stimulation-induced suppression of morphine-induced CCP in rats: A role for dopamine in the nucleus accumbens".BRAIN RESEARCH 1212.1212(2008):63-70.
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