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Efficacy of recombinant tissue-type plasminogen activator thrombolysis and primary coronary stenting after acute myocardial infarction
Chen, BX; Wang, WM; Zhao, H; Hu, DY; Xu, CB; Zhao, MZ; Lu, MY; Liu, J; Wu, C
关键词myocardial infarction therapeutic thrombolysis plasminogen activator
刊名CHINESE MEDICAL JOURNAL
2003
116期:1页:142-144
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]IMPLANTATION ; ANGIOPLASTY
英文摘要

Objective To compare the efficacy of low dose recombinant tissue-type plasminogen activator (rt-PA) thrombolysis with primary coronary stenting after acute myocardial infarction.

Methods Of 261 patients with first acute myocardial infarction, 131 were given low dose rt-PA intravenous thrombolysis, and 130 primary coronary stenting.

Results The age, time from onset of chest pain to hospital presentation and infarct location between these two groups were comparable. The patency rate of the infarct-related artery (IRA) in patients in the thrombolysis group was significantly lower than that of patients in the primary stenting group (P < 0.001). Recurrent myocardial infarction, and selective coronary stenting of patients with thrombolytic therapy were higher than that of patients in the primary stenting group (7.6% vs 1.5%, P < 0.05; 20.6% vs 0, P < 0. 001, respectively). Left ventricular ejection fraction (LVEF) in patients in the thrombolysis group was lower than that of the stent group (55.6% +/- 13.4% vs 65.8% +/- 9.2%, P < 0.001). Total hospitalization time of the thrombolysis group was longer than that of the stent group (16 +/- 7 d vs 11 +/- 4 d, P < 0.001). Mortality in the thrombolysis group was higher than that of the stent group, but this difference was not significant (6.1% vs 3.1%, P > 0.05).

Conclusion Comparing with low dose rt-PA thrombolytic therapy after acute myocardial infarction, primary coronary stenting has a higher patency rate of the IRA, better cardiac function and shorter hospitalization time.

语种英语
WOS记录号WOS:000181239800032
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65348
专题北京大学第二临床医学院_心血管内科
作者单位1.Beijing Elect Power Gen Hosp, Dept Cardiol, Beijing 100073, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
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GB/T 7714
Chen, BX,Wang, WM,Zhao, H,et al. Efficacy of recombinant tissue-type plasminogen activator thrombolysis and primary coronary stenting after acute myocardial infarction[J]. CHINESE MEDICAL JOURNAL,2003,116(1):142-144.
APA Chen, BX.,Wang, WM.,Zhao, H.,Hu, DY.,Xu, CB.,...&Wu, C.(2003).Efficacy of recombinant tissue-type plasminogen activator thrombolysis and primary coronary stenting after acute myocardial infarction.CHINESE MEDICAL JOURNAL,116(1),142-144.
MLA Chen, BX,et al."Efficacy of recombinant tissue-type plasminogen activator thrombolysis and primary coronary stenting after acute myocardial infarction".CHINESE MEDICAL JOURNAL 116.1(2003):142-144.
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