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学科主题: 临床医学
题名:
Incidence and species distribution of candidaemia in Asia: a laboratory-based surveillance study
作者: Tan, B. H.1; Chakrabarti, A.2; Li, R. Y.3; Patel, A. K.4; Watcharananan, S. P.5; Liu, Z.6; Chindamporn, A.7; Tan, A. L.8; Sun, P-L9; Wu, U-L.10; Chen, Y-C.11,12,13; AFWG
关键词: Asia ; candidaemia ; disease burden ; epidemiology ; geographic ; incidence ; species identification ; surveillance
刊名: CLINICAL MICROBIOLOGY AND INFECTION
发表日期: 2015-10-01
DOI: 10.1016/j.cmi.2015.06.010
卷: 21, 期:10, 页:946-953
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology
研究领域[WOS]: Infectious Diseases ; Microbiology
关键词[WOS]: ANTIFUNGAL DRUG-RESISTANCE ; INTENSIVE-CARE-UNIT ; INVASIVE CANDIDIASIS ; CANDIDEMIA ; EPIDEMIOLOGY ; FUNGEMIA ; SUSCEPTIBILITY ; POSITIVITY ; TAIWAN ; KOREA
英文摘要:

The epidemiology of candidaemia varies between hospitals and geographic regions. Although there are many studies from Asia, a large-scale cross-sectional study across Asia has not been performed. We conducted a 12-month, laboratory-based surveillance of candidaemia at 25 hospitals from China, Hong Kong, India, Singapore, Taiwan and Thailand. The incidence and species distribution of candidaemia were determined. There were 1601 episodes of candidaemia among 1.2 million discharges. The overall incidence was 1.22 episodes per 1000 discharges and varied among the hospitals (range 0.16-4.53 per 1000 discharges) and countries (range 0.25-2.93 per 1000 discharges). The number of Candida blood isolates and the total number of fungal isolates were highly correlated among the six countries (R-2 = 0.87) and 25 hospitals (R-2 = 0.77). There was a moderate correlation between incidence of candidaemia and the intensive care unit (ICU)/total bed ratio (R-2 = 0.47), although ICUs contributed to only 23% of candidaemia cases. Of 1910 blood isolates evaluated, Candida albicans was most frequently isolated (41.3%), followed by Candida tropicalis (25.4%), Candida glabrata (13.9%) and Candida parapsilosis (12.1%). The proportion of C. tropicalis among blood isolates was higher in haemato-oncology wards than others wards (33.7% versus 24.5%, p 0.0058) and was more likely to be isolated from tropical countries than other Asian countries (46.2% versus 18.9%, p 0.04). In conclusion, the ICU settings contribute, at least in part, to the incidence variation among hospitals. The species distribution is different from Western countries. Both geographic and healthcare factors contribute to the variation of species distribution. Clinical Microbiology and Infection (C) 2015 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.

语种: 英语
所属项目编号: 201108019RC
项目资助者: Pfizer
WOS记录号: WOS:000362924700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65350
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Coll Med, Taipei, Taiwan
2.Singapore Gen Hosp, Dept Infect Dis, Singapore, Singapore
3.Sterling Hosp, Dept Infect Dis, Ahmadabad, Gujarat, India
4.Singapore Gen Hosp, Dept Pathol, Singapore, Singapore
5.Mackay Mem Hosp, Dept Dermatol, Taipei, Taiwan
6.Postgrad Inst Med Educ & Res, Dept Med Microbiol, Chandigarh 160012, India
7.Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol, Beijing 100871, Peoples R China
8.Mahidol Univ, Ramathibodi Hosp, Fac Med, Div Infect Dis,Dept Med, Bangkok 10400, Thailand
9.Beijing Union Med Coll Hosp, Dept Infect Dis, Beijing, Peoples R China
10.Chulalongkorn Univ, Fac Med, King Chulalongkorn Mem Hosp, Dept Microbiol, Bangkok 10330, Thailand
11.Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan
12.Natl Taiwan Univ Hosp, Dept Med, Taipei, Taiwan
13.Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol, Miaoli, Miaoli County, Taiwan

Recommended Citation:
Tan, B. H.,Chakrabarti, A.,Li, R. Y.,et al. Incidence and species distribution of candidaemia in Asia: a laboratory-based surveillance study[J]. CLINICAL MICROBIOLOGY AND INFECTION,2015,21(10):946-953.
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