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学科主题: 药学
题名:
Effects of verbascoside and luteolin on oxidative damage in brain of heroin treated mice
作者: Zheng, QS; Zhang, YT; Zheng, RL; Guo, D; Li, CL
刊名: PHARMAZIE
发表日期: 2005-07-01
卷: 60, 期:7, 页:539-543
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: FREELY MOVING RATS ; ASCORBIC-ACID ; URIC-ACID ; MORPHINE ; GLUTATHIONE ; CELLS ; DRUGS ; WITHDRAWAL ; DNA ; PEROXIDATION
英文摘要:

Extensive but fragmentary studies have shown: (i) heroin, morphine and opiates are able to induce reactive oxygen species (ROS) formation in several cells, (ii) they decrease the antioxidant defense system including enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and antioxidants, glutathione (GSH), Se, and vitamins. This study is to investigate the oxidative damage to DNA, proteins, and lipids in brain of mice administered heroin via intraperitoneal injection, and the effects of verbascoside and luteolin on this damage. All the indices of oxidative damage, such as 8-hydroxy-2′-deoxyguanosine (8-OHdG), protein carbonyl group and malondialdehyde (MDA) contents increased significantly compared to those of controls in the brains of heroin-administered mice, while the indices related to the in vivo antioxidative capacity, such as the ratio of GSH and oxidized glutathione (GSSG), and activities of SOD, CAT and GPx in the brain, and total antioxidant capacity (TAC) in serum significantly decreased. When heroin-dependent mice were treated with verbascoside or luteolin, oxidative stress status was limited.

语种: 英语
WOS记录号: WOS:000230541900012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65357
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
2.Lanzhou Univ, Inst Biophys, Sch Life Sci, Lanzhou, Peoples R China
3.Yantai Univ, Ocean Sch, Yantai, Peoples R China

Recommended Citation:
Zheng, QS,Zhang, YT,Zheng, RL,et al. Effects of verbascoside and luteolin on oxidative damage in brain of heroin treated mice[J]. PHARMAZIE,2005,60(7):539-543.
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