IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration
An, Zhengwen1; Dobra, Katalin2; Lock, John G.1; Stromblad, Staffan1; Hjerpe, Anders2; Zhang, Hongquan1,3,4
关键词Kindlin-2 malignant mesothelioma adhesion and migration tumor progression
刊名INTERNATIONAL JOURNAL OF CANCER
2010-11-01
DOI10.1002/ijc.25223
127期:9页:1999-2008
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]INTEGRIN-LINKED KINASE ; MITOGEN-INDUCIBLE GENE-2 ; EPITHELIAL-CELLS ; KINDLER-SYNDROME ; PROGNOSTIC-FACTORS ; GROWTH-FACTOR ; BETA-CATENIN ; PROTEIN ; ILK ; ACTIVATION
英文摘要

Kindlin-2 is a novel integrin-interacting focal adhesion protein that belongs to the Kindlin family. Focal adhesion proteins control cytoskeleton dynamics and promote cancer cell growth, survival, migration and metastasis. Little is known, however, about expression of Kindlin-2 in association with human cancer. We now reveal high Kindlin-2 expression in malignant mesothelioma (MM) cell lines using an affinity-purified anti-Kindlin-2 antibody. Furthermore, we show by immunohistochemistry that Kindlin-2 is highly expressed in 92 of 102 (90%) MMs with epitheliod; sarcomatoid, biphasic and poorly differentiated morphologies. In addition, Kindlin-2 expression correlates to cell proliferation, suggesting a role for Kindlin-2 in tumor growth. We also detect increased expression of Kindlin-2 at the invasion front of tumors concurrent with increased expression of integrin-linked kinase, a Kindlin-binding protein. Besides the high expression of Kindlin-2 in pleural MMs, pleural metastases of lung adenocarcinoma also express large amounts of Kindlin-2, but not Kindlin-1. Notably, in vitro, when endogenous Kindlin-2 was knocked down with RNAi in MM cells, this impaired cell spreading, adhesion and migration. Overall, our study suggests that heightened expression of Kindlin-2 might contribute to tumor progression in MM.

语种英语
WOS记录号WOS:000282539600002
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65359
专题北京大学基础医学院
作者单位1.Karolinska Inst, Dept Biosci & Nutr Novum, Unit Clin Mol Biol, SE-14183 Stockholm, Sweden
2.Karolinska Inst, Dept Lab Med, Div Pathol, SE-14183 Stockholm, Sweden
3.Peking Univ, Sch Basic Med Sci, Lab Mol Cell Biol & Tumor Biol, Beijing 100191, Peoples R China
4.Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
An, Zhengwen,Dobra, Katalin,Lock, John G.,et al. Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration[J]. INTERNATIONAL JOURNAL OF CANCER,2010,127(9):1999-2008.
APA An, Zhengwen,Dobra, Katalin,Lock, John G.,Stromblad, Staffan,Hjerpe, Anders,&Zhang, Hongquan.(2010).Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration.INTERNATIONAL JOURNAL OF CANCER,127(9),1999-2008.
MLA An, Zhengwen,et al."Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration".INTERNATIONAL JOURNAL OF CANCER 127.9(2010):1999-2008.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[An, Zhengwen]的文章
[Dobra, Katalin]的文章
[Lock, John G.]的文章
百度学术
百度学术中相似的文章
[An, Zhengwen]的文章
[Dobra, Katalin]的文章
[Lock, John G.]的文章
必应学术
必应学术中相似的文章
[An, Zhengwen]的文章
[Dobra, Katalin]的文章
[Lock, John G.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。