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学科主题: 基础医学
题名:
Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration
作者: An, Zhengwen1; Dobra, Katalin2; Lock, John G.1; Stromblad, Staffan1; Hjerpe, Anders2; Zhang, Hongquan1,3,4
关键词: Kindlin-2 ; malignant mesothelioma ; adhesion and migration ; tumor progression
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2010-11-01
DOI: 10.1002/ijc.25223
卷: 127, 期:9, 页:1999-2008
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: INTEGRIN-LINKED KINASE ; MITOGEN-INDUCIBLE GENE-2 ; EPITHELIAL-CELLS ; KINDLER-SYNDROME ; PROGNOSTIC-FACTORS ; GROWTH-FACTOR ; BETA-CATENIN ; PROTEIN ; ILK ; ACTIVATION
英文摘要:

Kindlin-2 is a novel integrin-interacting focal adhesion protein that belongs to the Kindlin family. Focal adhesion proteins control cytoskeleton dynamics and promote cancer cell growth, survival, migration and metastasis. Little is known, however, about expression of Kindlin-2 in association with human cancer. We now reveal high Kindlin-2 expression in malignant mesothelioma (MM) cell lines using an affinity-purified anti-Kindlin-2 antibody. Furthermore, we show by immunohistochemistry that Kindlin-2 is highly expressed in 92 of 102 (90%) MMs with epitheliod; sarcomatoid, biphasic and poorly differentiated morphologies. In addition, Kindlin-2 expression correlates to cell proliferation, suggesting a role for Kindlin-2 in tumor growth. We also detect increased expression of Kindlin-2 at the invasion front of tumors concurrent with increased expression of integrin-linked kinase, a Kindlin-binding protein. Besides the high expression of Kindlin-2 in pleural MMs, pleural metastases of lung adenocarcinoma also express large amounts of Kindlin-2, but not Kindlin-1. Notably, in vitro, when endogenous Kindlin-2 was knocked down with RNAi in MM cells, this impaired cell spreading, adhesion and migration. Overall, our study suggests that heightened expression of Kindlin-2 might contribute to tumor progression in MM.

语种: 英语
所属项目编号: 30830048 ; 201003912203
项目资助者: Swedish Cancer Foundation ; Swedish Society of Medicine ; Swedish Research Council ; Heart Lung funds ; AFA insurance research funds ; Karolinska Institute funds ; Peking University ; Nature Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000282539600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65359
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Karolinska Inst, Dept Biosci & Nutr Novum, Unit Clin Mol Biol, SE-14183 Stockholm, Sweden
2.Karolinska Inst, Dept Lab Med, Div Pathol, SE-14183 Stockholm, Sweden
3.Peking Univ, Sch Basic Med Sci, Lab Mol Cell Biol & Tumor Biol, Beijing 100191, Peoples R China
4.Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China

Recommended Citation:
An, Zhengwen,Dobra, Katalin,Lock, John G.,et al. Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration[J]. INTERNATIONAL JOURNAL OF CANCER,2010,127(9):1999-2008.
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