IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Connective tissue growth factor induces transformation of renal fibroblasts into myofibroblasts
Huang, HC; Li, JZ; Wang, HY
关键词connective tissue growth factor fibroblasts myofibroblast fibrosis
刊名CHINESE SCIENCE BULLETIN
2002-05-01
47期:9页:741-+
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]FIBROSIS ; EXPRESSION ; CELLS
英文摘要

Connective tissue growth factor (CTGF) is thought to be a specific mediator of TGF-beta profibrogenic effect, but the role of CTGF in the transformation of renal fibroblasts to myofibroblasts, which are the most important host cells in the renal chronic fibrosis, is still unknown. Aimed at observing the biological effect of CTGF, we set up a cell line overexpressing CTGF, and analyzed the amount of myofibroblast and the level of extracellular matrix Collagen III mRNA in cultured cells. Our results show that CTGF can directly induce myofibroblasts formation, and increase the level of Collagen III mRNA. This suggests that CTGF may be a novel pharmacotherapeutical target protein for the interference with renal fibrosis, thus providing useful theoretic possibility for clinical prevention of chronic progression of kidney disease.

语种英语
WOS记录号WOS:000174980900008
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65363
专题北京大学第一临床医学院_肾脏内科
作者单位Peking Univ First Hosp, Inst Nephrol, Div Renal, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Huang, HC,Li, JZ,Wang, HY. Connective tissue growth factor induces transformation of renal fibroblasts into myofibroblasts[J]. CHINESE SCIENCE BULLETIN,2002,47(9):741-+.
APA Huang, HC,Li, JZ,&Wang, HY.(2002).Connective tissue growth factor induces transformation of renal fibroblasts into myofibroblasts.CHINESE SCIENCE BULLETIN,47(9),741-+.
MLA Huang, HC,et al."Connective tissue growth factor induces transformation of renal fibroblasts into myofibroblasts".CHINESE SCIENCE BULLETIN 47.9(2002):741-+.
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