|Effect of combining different calcium concentration dialysate on calcium balance in peritoneal dialysis patients|
|Zhao Hui-ping; Wu Bei; Lu Li-xia; Qiao Jie; Wu Xiang-lan; Wang Mei|
|关键词||peritoneal dialysis calcium phosphate metabolism dialysate calcium concentration parathyroid hormone|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||STAGE RENAL-DISEASE ; MINERAL METABOLISM ; SECONDARY HYPERPARATHYROIDISM ; ADYNAMIC BONE ; CAPD PATIENTS ; MORTALITY ; HYPERPHOSPHATEMIA ; CALCIFICATION ; HEMODIALYSIS ; MANAGEMENT|
Background Calcium and phosphorus metabolic disturbance are common in dialysis patients and associated with increased morbidity and mortality. Therefore, maintaining the balance of calcium and phosphate metabolism and suitable intact parathyroid hormone (iPTH) level has become the focus of attention. We investigated the effects of different peritoneal dialysate calcium concentrations on calcium phosphate metabolism and iPTH in continuous ambulatory peritoneal dialysis (CAPD) patients.
Methods Forty stable CAPD patients with normal serum calcium were followed for six months of treatment with 1.25 mmol/L calcium dialysate (DCa1.25, PD4, 22 patients) or a combination of 1.75 mmol/L calcium dialysate (DCa1.75, PD2) and PD4 (18 patients) twice a day respectively. Total serum calcium (after albumin correction), serum phosphorus, iPTH, alkaline phosphatase (ALP) and blood pressure were recorded before and 1, 3 and 6 months after treatment commenced.
Results No significant difference was found in baseline serum calcium, phosphorus between the two patient groups, but the levels of iPTH were significantly different. No significant changes were found in the dosage of calcium carbonate and active vitamin D during 6 months. In the PD4 group, serum calcium level at the 1st, 3rd, 6th months were significantly lower than the baseline (P <0.05). There was no significant difference in serum phosphorus after 6 months treatment. iPTH was significantly higher (P <0.001) at the 1st, 3rd, and 6th months compared with the baseline. No differences were seen in ALP and blood pressure. In the PD4+PD2 group, no significant changes in serum calcium, phosphorus, iPTH, ALP and BP during the 6-month follow-up period.
Conclusions Treatment with 1.25 mmol/L calcium dialysate for six months can decrease serum calcium, increase iPTH, without change in serum phosphorus, ALP, and BP. The combining of PD4 and PD2 can stabilize the serum calcium and avoid fluctuations in iPTH levels. Chin Med J 2012;125(22):4009-4013
|作者单位||Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100044, Peoples R China|
|Zhao Hui-ping,Wu Bei,Lu Li-xia,et al. Effect of combining different calcium concentration dialysate on calcium balance in peritoneal dialysis patients[J]. CHINESE MEDICAL JOURNAL,2012,125(22):4009-4013.|
|APA||Zhao Hui-ping,Wu Bei,Lu Li-xia,Qiao Jie,Wu Xiang-lan,&Wang Mei.(2012).Effect of combining different calcium concentration dialysate on calcium balance in peritoneal dialysis patients.CHINESE MEDICAL JOURNAL,125(22),4009-4013.|
|MLA||Zhao Hui-ping,et al."Effect of combining different calcium concentration dialysate on calcium balance in peritoneal dialysis patients".CHINESE MEDICAL JOURNAL 125.22(2012):4009-4013.|