学科主题临床医学
Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein
Han, Jinchao; Pan, Xiaoben; Gao, Yan; Weil, Lai
关键词Hepatitis B virus Hepatitis B core protein Nucleocapsid Antiviral peptide
刊名VIRUS RESEARCH
2010-06-01
DOI10.1016/j.virusres.2010.03.005
150期:1-2页:129-134
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]IN-VIVO ; CAPSID PROTEIN ; PEPTIDE ; DNA ; NUCLEOCAPSIDS ; DRUG ; RNA ; LOCALIZATION ; TERMINUS ; MUTATION
英文摘要

The nucleocapsids formation is a pivotal step of hepatitis B virus (HBV) life cycle. The inhibition of HBV nucleocapsids assembly is a promising strategy for the anti-HBV treatment. HBc78-117 is an internal fragment of hepatitis B core protein (HBc). In this study, we used lentiviral vector to deliver HBc78-117 cDNA sequence into HepG2.2.15 cells and examined the effect of H8c78-117 on HBV replication. We confirmed by immunoprecipitation analysis that HBc78-117 interacted with full-length HBc in HepG2.2.15 cells. The nucleocapsids and HBV DNA replication intermediates were markedly reduced in the cells expressing HBc78-117, although HBV pregenome RNA was not affected. The level of HBV DNA was also significantly reduced in culture supernatant. These suggest that HBc78-117 can inhibit HBV DNA replication by interfering with nucleocapsids assembly. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000277821200016
项目编号30872233 ; 30700697
资助机构National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65365
专题北京大学第二临床医学院_北京大学肝病研究所
北京大学第二临床医学院_感染科
作者单位Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China
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Han, Jinchao,Pan, Xiaoben,Gao, Yan,et al. Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein[J]. VIRUS RESEARCH,2010,150(1-2):129-134.
APA Han, Jinchao,Pan, Xiaoben,Gao, Yan,&Weil, Lai.(2010).Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein.VIRUS RESEARCH,150(1-2),129-134.
MLA Han, Jinchao,et al."Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein".VIRUS RESEARCH 150.1-2(2010):129-134.
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