北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所  > 期刊论文
学科主题: 临床医学
题名:
Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein
作者: Han, Jinchao; Pan, Xiaoben; Gao, Yan; Weil, Lai
关键词: Hepatitis B virus ; Hepatitis B core protein ; Nucleocapsid ; Antiviral peptide
刊名: VIRUS RESEARCH
发表日期: 2010-06-01
DOI: 10.1016/j.virusres.2010.03.005
卷: 150, 期:1-2, 页:129-134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: IN-VIVO ; CAPSID PROTEIN ; PEPTIDE ; DNA ; NUCLEOCAPSIDS ; DRUG ; RNA ; LOCALIZATION ; TERMINUS ; MUTATION
英文摘要:

The nucleocapsids formation is a pivotal step of hepatitis B virus (HBV) life cycle. The inhibition of HBV nucleocapsids assembly is a promising strategy for the anti-HBV treatment. HBc78-117 is an internal fragment of hepatitis B core protein (HBc). In this study, we used lentiviral vector to deliver HBc78-117 cDNA sequence into HepG2.2.15 cells and examined the effect of H8c78-117 on HBV replication. We confirmed by immunoprecipitation analysis that HBc78-117 interacted with full-length HBc in HepG2.2.15 cells. The nucleocapsids and HBV DNA replication intermediates were markedly reduced in the cells expressing HBc78-117, although HBV pregenome RNA was not affected. The level of HBV DNA was also significantly reduced in culture supernatant. These suggest that HBc78-117 can inhibit HBV DNA replication by interfering with nucleocapsids assembly. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30872233 ; 30700697
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000277821200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65365
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Han, Jinchao,Pan, Xiaoben,Gao, Yan,et al. Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein[J]. VIRUS RESEARCH,2010,150(1-2):129-134.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Han, Jinchao]'s Articles
[Pan, Xiaoben]'s Articles
[Gao, Yan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Han, Jinchao]‘s Articles
[Pan, Xiaoben]‘s Articles
[Gao, Yan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace