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学科主题: 临床医学
题名:
Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein
作者: Han, Jinchao; Pan, Xiaoben; Gao, Yan; Weil, Lai
关键词: Hepatitis B virus ; Hepatitis B core protein ; Nucleocapsid ; Antiviral peptide
刊名: VIRUS RESEARCH
发表日期: 2010-06-01
DOI: 10.1016/j.virusres.2010.03.005
卷: 150, 期:1-2, 页:129-134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: IN-VIVO ; CAPSID PROTEIN ; PEPTIDE ; DNA ; NUCLEOCAPSIDS ; DRUG ; RNA ; LOCALIZATION ; TERMINUS ; MUTATION
英文摘要:

The nucleocapsids formation is a pivotal step of hepatitis B virus (HBV) life cycle. The inhibition of HBV nucleocapsids assembly is a promising strategy for the anti-HBV treatment. HBc78-117 is an internal fragment of hepatitis B core protein (HBc). In this study, we used lentiviral vector to deliver HBc78-117 cDNA sequence into HepG2.2.15 cells and examined the effect of H8c78-117 on HBV replication. We confirmed by immunoprecipitation analysis that HBc78-117 interacted with full-length HBc in HepG2.2.15 cells. The nucleocapsids and HBV DNA replication intermediates were markedly reduced in the cells expressing HBc78-117, although HBV pregenome RNA was not affected. The level of HBV DNA was also significantly reduced in culture supernatant. These suggest that HBc78-117 can inhibit HBV DNA replication by interfering with nucleocapsids assembly. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30872233 ; 30700697
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000277821200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65365
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Han, Jinchao,Pan, Xiaoben,Gao, Yan,et al. Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein[J]. VIRUS RESEARCH,2010,150(1-2):129-134.
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