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学科主题: 临床医学
题名:
Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population
作者: Han, Xueyao; Luo, Yingying; Ren, Qian; Zhang, Xiuying; Wang, Fang; Sun, Xiuqin; Zhou, Xianghai; Ji, Linong
刊名: BMC MEDICAL GENETICS
发表日期: 2010-05-28
DOI: 10.1186/1471-2350-11-81
卷: 11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: GENOME-WIDE ASSOCIATION ; IMPAIRED FASTING GLUCOSE ; BETA-CELL FUNCTION ; COMMON VARIANTS ; HAN POPULATION ; INSULIN-SECRETION ; PLASMA-GLUCOSE ; RISK LOCI ; FAT MASS ; SUSCEPTIBILITY
英文摘要:

Background: Recently, several genome-wide and candidate gene association studies have identified many novel genetic loci for type 2 diabetes (T2D); among these genes, CDKAL1, IGF2BP2, SLC30A8, CDKN2A/B, HHEX, FTO, TCF2, KCNQ1, and WFS1 are the most important. We aimed to determine the effects of these genetic loci associated with T2D in the Chinese Han population of China.

Methods: Single-nucleotide polymorphisms (SNPs) in or near CDKAL1, IGF2BP2, SLC30A8, CDKN2A/B, HHEX, FTO, TCF2, KCNQ1, and WFS1 genes were genotyped in a case-control Chinese Han sample living in Beijing, China involving 1024 patients with T2D and 1005 control subjects.

Results: In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index. Not only did an association between WFS1-rs6446482 and early-onset T2D exist in the subgroup analysis, but TCF2-rs7501939 and WFS1-rs6446482 were also confirmed to confer risk for T2D in this meta-analysis. Moreover, the relationship between FTO-rs8050136 and body mass index, together with the effect of CDKAL1-rs10946398 on beta cell function, was also observed in the control individuals.

Conclusions: Our findings support the important contribution of these genetic loci to susceptibility for T2D in the Chinese Han population in Beijing of China.

语种: 英语
所属项目编号: 30570873 ; 30771031 ; 2006CB503900 ; PUDC2007-2 ; 2006AA02A409 ; RDC2007-27
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 program) ; Peking University ; National High Technology Research and Development Program (863 program) ; Peking University People&prime ; s Hospital
WOS记录号: WOS:000279920300002
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65367
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Ctr Diabet, Beijing 100044, Peoples R China

Recommended Citation:
Han, Xueyao,Luo, Yingying,Ren, Qian,et al. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population[J]. BMC MEDICAL GENETICS,2010,11.
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