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Dopamine beta-Hydroxylase Gene Associates With Stroop Color-Word Task Performance in Han Chinese Children With Attention Deficit/Hyperactivity Disorder
Ji, Ning1; Lan Shuai1; Chen, Yun1; Liu, Lu1; Li, Hai-mei1; Li, Ze-hua1; Yang, Li1; Qian, Qiu-jin1; Tang, Yi-lang2; Cubells, Joseph F.2,3; Wang, Yu-feng1
关键词attention deficit/hyperactivity disorder dopamine beta-hydroxylase cognitive function association endophenotype
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2011-09-01
DOI10.1002/ajmg.b.31215
156B期:6页:730-736
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; SINGLE NUCLEOTIDE POLYMORPHISM ; SUSTAINED ATTENTION ; DBH GENE ; EXECUTIVE FUNCTIONS ; CANDIDATE GENE ; DRD4 GENE ; ADHD ; ENDOPHENOTYPES ; INTERFERENCE
英文摘要

The cognitive deficits observed in attention deficit/hyperactivity disorder (ADHD) are candidate endophenotypes for genetic association studies. Dopamine beta-hydroxylase (D beta H) converts dopamine to norepinephrine, and its activity is under strong genetic control. Prior studies suggest association between ADHD and DBH gene. The present study examined associations between a putative functional single nucleotide polymorphism (SNP) at DBH with performance on the Stroop task in patients with ADHD and in healthy control subjects. A total of 812 Han Chinese youths with DSM-IV ADHD and 233 unaffected controls were included in the study. Comprehensive phenotype data were collected, including performance on a series of Stroop interference tests examining inhibition of response to interfering stimuli. DBHSNP -1021C/T was genotyped using the 5′-exonuclease (TaqMan (R)) method. Compared to unaffected controls, children with ADHD performed significantly worse in all categories of the Stroop test. In ADHD cases, DBH genotype at -1021C/T significantly associates with reaction times of incongruent color word parts but not the interference times, with TT genotype performing significantly better in both reaction time and interference time than other two genotype groups. DBH genotype did not associate with cognitive performance in unaffected controls or in the combined group. DBH genotype at -1021C/T associates with differences in performance on the Stroop task in children with ADHD. (C) 2011 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000294228600011
项目编号2007BAI17B03 ; 81071109 ; 30800302 ; 200802073
资助机构National Foundation, Ministry of Science and Technology, China ; National Natural Sciences Foundation of China ; National Natural Science Foundation of Chin ; Commonweal Sciences Foundation, Ministry of Health, China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65368
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Emory Univ Sch Med, Dept Human Genet, Atlanta, GA USA
3.Emory Univ Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA
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GB/T 7714
Ji, Ning,Lan Shuai,Chen, Yun,et al. Dopamine beta-Hydroxylase Gene Associates With Stroop Color-Word Task Performance in Han Chinese Children With Attention Deficit/Hyperactivity Disorder[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2011,156B(6):730-736.
APA Ji, Ning.,Lan Shuai.,Chen, Yun.,Liu, Lu.,Li, Hai-mei.,...&Wang, Yu-feng.(2011).Dopamine beta-Hydroxylase Gene Associates With Stroop Color-Word Task Performance in Han Chinese Children With Attention Deficit/Hyperactivity Disorder.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,156B(6),730-736.
MLA Ji, Ning,et al."Dopamine beta-Hydroxylase Gene Associates With Stroop Color-Word Task Performance in Han Chinese Children With Attention Deficit/Hyperactivity Disorder".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 156B.6(2011):730-736.
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