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学科主题: 精神卫生
题名:
Dopamine beta-Hydroxylase Gene Associates With Stroop Color-Word Task Performance in Han Chinese Children With Attention Deficit/Hyperactivity Disorder
作者: Ji, Ning1; Lan Shuai1; Chen, Yun1; Liu, Lu1; Li, Hai-mei1; Li, Ze-hua1; Yang, Li1; Qian, Qiu-jin1; Tang, Yi-lang2; Cubells, Joseph F.2,3; Wang, Yu-feng1
关键词: attention deficit/hyperactivity disorder ; dopamine beta-hydroxylase ; cognitive function ; association ; endophenotype
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2011-09-01
DOI: 10.1002/ajmg.b.31215
卷: 156B, 期:6, 页:730-736
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: DEFICIT HYPERACTIVITY DISORDER ; SINGLE NUCLEOTIDE POLYMORPHISM ; SUSTAINED ATTENTION ; DBH GENE ; EXECUTIVE FUNCTIONS ; CANDIDATE GENE ; DRD4 GENE ; ADHD ; ENDOPHENOTYPES ; INTERFERENCE
英文摘要:

The cognitive deficits observed in attention deficit/hyperactivity disorder (ADHD) are candidate endophenotypes for genetic association studies. Dopamine beta-hydroxylase (D beta H) converts dopamine to norepinephrine, and its activity is under strong genetic control. Prior studies suggest association between ADHD and DBH gene. The present study examined associations between a putative functional single nucleotide polymorphism (SNP) at DBH with performance on the Stroop task in patients with ADHD and in healthy control subjects. A total of 812 Han Chinese youths with DSM-IV ADHD and 233 unaffected controls were included in the study. Comprehensive phenotype data were collected, including performance on a series of Stroop interference tests examining inhibition of response to interfering stimuli. DBHSNP -1021C/T was genotyped using the 5′-exonuclease (TaqMan (R)) method. Compared to unaffected controls, children with ADHD performed significantly worse in all categories of the Stroop test. In ADHD cases, DBH genotype at -1021C/T significantly associates with reaction times of incongruent color word parts but not the interference times, with TT genotype performing significantly better in both reaction time and interference time than other two genotype groups. DBH genotype did not associate with cognitive performance in unaffected controls or in the combined group. DBH genotype at -1021C/T associates with differences in performance on the Stroop task in children with ADHD. (C) 2011 Wiley-Liss, Inc.

语种: 英语
所属项目编号: 2007BAI17B03 ; 81071109 ; 30800302 ; 200802073
项目资助者: National Foundation, Ministry of Science and Technology, China ; National Natural Sciences Foundation of China ; National Natural Science Foundation of Chin ; Commonweal Sciences Foundation, Ministry of Health, China
WOS记录号: WOS:000294228600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65368
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Emory Univ Sch Med, Dept Human Genet, Atlanta, GA USA
3.Emory Univ Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA

Recommended Citation:
Ji, Ning,Lan Shuai,Chen, Yun,et al. Dopamine beta-Hydroxylase Gene Associates With Stroop Color-Word Task Performance in Han Chinese Children With Attention Deficit/Hyperactivity Disorder[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2011,156B(6):730-736.
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