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An Exploratory Study on Tc-99m-RGD-BBN Peptide Scintimammography in the Assessment of Breast Malignant Lesions Compared to Tc-99m-3P4-RGD2
Chen, Qianqian1; Ma, Qingjie1; Chen, Minglong1; Chen, Bin1; Wen, Qiang1; Jia, Bing2; Wang, Fan2; Sun, Butong1; Gao, Shi1
刊名PLOS ONE
2015-04-07
DOI10.1371/journal.pone.0123401
10期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GASTRIN-RELEASING-PEPTIDE ; POSITRON-EMISSION-TOMOGRAPHY ; BOMBESIN ANALOGS ; RECEPTOR ; CANCER ; EXPRESSION ; MODEL
英文摘要

Purpose

This study aimed to explore the diagnostic performance of single photon emission computed tomography / computerized tomography (SPECT/CT) using a new radiotracer Tc-99m-RGD-BBN for breast malignant tumor compared with Tc-99m-3P4-RGD(2).

Methods

6 female patients with breast malignant tumors diagnosed by fine needle aspiration cytology biopsy (FNAB) who were scheduled to undergo surgery were included in the study. Tc-99m-3P4-RGD(2) and 99mTc-RGD-BBN were performed with single photon emission computed tomography (SPECT) at 1 hour after intravenous injection of 299 +/- 30 MBq and 293 +/- 32 MBq of radiotracers respectively at separate day. The results were evaluated by the Tumor to non-Tumor ratios (T/NT). Tc-99m-RGD-BBN and Tc-99m-3P4-RGD(2) SPECT/CT images were interpreted independently by 3 experienced nuclear medicine physicians using a 3-point scale system. All of the samples were analyzed immunohistochemically to evaluate the integrin alpha v beta 3 and gastrin-releasing peptide receptor (GRPR) expression. The safety, biodistribution and radiation dosimetry of Tc-99m-RGD-BBN were also evaluated in the healthy volunteers.

Results

No serious adverse events were reported in any of the patients during the study. The effective radiation dose entirely conformed to the relevant standards. A total of 6 palpable malignant lesions were detected using Tc-99m-RGD-BBN SPECT/CT with clear uptake. All malignant lesions were also detected using Tc-99m-3P4-RGD(2) SPECT/CT. The results showed that five malignant lesions were with clear uptake and the other one with barely an uptake. 4 malignant cases were found with both alpha v beta 3 and GRPR expression, 1 case with only GRPR positive expression (integrin alpha v beta 3 negative) and 1 case with only integrin alpha nu beta 3 positive expression (GRPR negative).

Conclusion

Tc-99m-RGD-BBN is a safe agent for detecting breast cancer. Tc-99m-RGD-BBN may have the potential to make up for the deficiency of Tc-99m-3P4-RGD(2) in the detection of breast cancer with only GRPR positive expression (integrin alpha(v)beta(3) negative). The preliminary application of Tc-99m-RGD-BBN has demonstrated its powerful potential in breast cancer diagnosis and therapy.

语种英语
WOS记录号WOS:000352477800230
项目编号81271606 ; 201015185 ; 201115088
资助机构National Natural Science Foundation of China (NSFC) projects ; Research Fund of Science and Technology Department of Jilin Province
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65372
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.Jilin Univ, China Japan Union Hosp, Dept Nucl Med, Changchun 130033, Peoples R China
2.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Qianqian,Ma, Qingjie,Chen, Minglong,et al. An Exploratory Study on Tc-99m-RGD-BBN Peptide Scintimammography in the Assessment of Breast Malignant Lesions Compared to Tc-99m-3P4-RGD2[J]. PLOS ONE,2015,10(4).
APA Chen, Qianqian.,Ma, Qingjie.,Chen, Minglong.,Chen, Bin.,Wen, Qiang.,...&Gao, Shi.(2015).An Exploratory Study on Tc-99m-RGD-BBN Peptide Scintimammography in the Assessment of Breast Malignant Lesions Compared to Tc-99m-3P4-RGD2.PLOS ONE,10(4).
MLA Chen, Qianqian,et al."An Exploratory Study on Tc-99m-RGD-BBN Peptide Scintimammography in the Assessment of Breast Malignant Lesions Compared to Tc-99m-3P4-RGD2".PLOS ONE 10.4(2015).
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