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学科主题: 基础医学
题名:
Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1
作者: Zhang, Dong-juan1,2; Chen, Li-hong1,2; Zhang, Ya-hua3; Yang, Guang-rui1,2; Dou, Dou1; Gao, Yuan-sheng1; Zhang, Xiao-yan1,2; Kong, Xiao-mu1,2; Zhao, Pan1,2; Pu, Dan1,2; Wei, Ming-fen1,2; Breyer, Matthew-D3; Guan, You-fei1,2
关键词: prostaglandin E2 ; membrane-associated prostaglandin E2 synthase-1 ; angiotensin II ; blood pressure ; resistant vessel
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2010-10-01
DOI: 10.1038/aps.2010.99
卷: 31, 期:10, 页:1284-1292
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; ANGIOTENSIN-II ; BLOOD-PRESSURE ; E-2 BIOSYNTHESIS ; CYCLOOXYGENASE-2 INHIBITORS ; THERAPEUTIC TARGET ; UP-REGULATION ; KIDNEY ; RECEPTOR ; HYPERTENSION
英文摘要:

Aim: To examine the contribution of vascular membrane-associated prostaglandin E2 synthase-1 (mPGES-1) to acute blood pressure homeostasis.

Methods: Angiotensin II (AngII, 75 pmol.kg(-1).min(-1)) was continuously infused via the jugular vein into wild-type and mPGES-1(-/-) mice for 30 min, and blood pressure was measured by carotid arterial catheterization. RT-PCR and immunohistochemistry were performed to detect the expression and localization of mPGES-1 in the mouse arterial vessels. Mesenteric arteries were dissected from mice of both genotypes to study vessel tension and measure vascular PGE2 levels.

Results: Wild-type and mPGES-1(-/-) mice showed similar blood pressure levels at baseline, and the acute intravenous infusion of AngII caused a greater increase in mean arterial pressure in the mPGES-1(-/-) group, with a similar diuretic and natriuretic response in both groups. mPGES-1 was constitutively expressed in the aortic and mesenteric arteries and vascular smooth muscle cells of wild-type mice. Strong staining was detected in the smooth muscle layer of arterial vessels. Ex vivo treatment of mesenteric arteries with AngII produced more vasodilatory PGE2 in wild-type than in mPGES-1(-/-) mice. In vitro tension assays further revealed that the mesenteric arteries of mPGES-1(-/-) mice exhibited a greater vasopressor response to AngII than those arteries of wild-type mice.

Conclusion: Vascular mPGES-1 acts as an important tonic vasodilator, contributing to acute blood pressure regulation.

语种: 英语
所属项目编号: 30530340/30725033 ; 2006CB503907 ; RO1 065074-04 ; PO1DK38226
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology ; National Institute of Diabetes and Digestive and Kidney Diseases
WOS记录号: WOS:000283398200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65376
Appears in Collections:基础医学院_北京大学糖尿病中心_期刊论文

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作者单位: 1.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Diabet, Beijing 100191, Peoples R China
3.Vanderbilt Univ, Med Ctr, Div Nephrol, Nashville, TN 37232 USA

Recommended Citation:
Zhang, Dong-juan,Chen, Li-hong,Zhang, Ya-hua,et al. Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1[J]. ACTA PHARMACOLOGICA SINICA,2010,31(10):1284-1292.
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