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Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3H)-ones in water
Yan, Xu; Zhou, Shuo; Wang, Yuanqiang; Ge, Zemei; Cheng, Tieming; Li, Runtao
关键词Substituted-1,3,4-oxadiazole-2(3H)-ones One-pot Tandem procedure Propylene oxide Environmentally friendly
刊名TETRAHEDRON
2012-09-23
DOI10.1016/j.tet.2012.07.004
68期:38页:7978-7983
收录类别SCI ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Natural Science Foundation of China ; State Key New Drug Development Program ; National Natural Science Foundation of China ; State Key New Drug Development Program
研究领域[WOS]Chemistry
关键词[WOS]MEDIATED SYNTHESIS ; B INHIBITORS ; DERIVATIVES ; EFFICIENT ; 1,3,4-OXADIAZOLES ; ANALOGS ; PHENYL ; DESIGN ; ACID
英文摘要

It has been developed for the synthesis of substituted-1,3,4-oxadiazole-2(3H)-one derivatives via a novel one-pot, tandem procedure assisted by propylene oxide. The 5-substitued-1,3,4-oxadiazole-2(3H)-ones and 3,5-disubstitued-1,3,4-oxadiazole-2(3H)-ones were, respectively, obtained from three-component reaction of acylhydrazines, carbon disulfide, and propylene oxide, and four-component reaction of acylhydarazines, carbon disulfide, propylene oxide, and organic halides. The reactions were carried out using water as solvent in the presence of potassium phosphate to afford the expected products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号21172011 ; 2009ZX09103-131
资助者National Natural Science Foundation of China ; State Key New Drug Development Program ; National Natural Science Foundation of China ; State Key New Drug Development Program
WOS记录号WOS:000308051600034
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65379
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yan, Xu,Zhou, Shuo,Wang, Yuanqiang,et al. Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3H)-ones in water[J]. TETRAHEDRON,2012,68(38):7978-7983.
APA Yan, Xu,Zhou, Shuo,Wang, Yuanqiang,Ge, Zemei,Cheng, Tieming,&Li, Runtao.(2012).Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3H)-ones in water.TETRAHEDRON,68(38),7978-7983.
MLA Yan, Xu,et al."Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3H)-ones in water".TETRAHEDRON 68.38(2012):7978-7983.
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