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学科主题: 药学
题名:
Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3H)-ones in water
作者: Yan, Xu; Zhou, Shuo; Wang, Yuanqiang; Ge, Zemei; Cheng, Tieming; Li, Runtao
关键词: Substituted-1,3,4-oxadiazole-2(3H)-ones ; One-pot ; Tandem procedure ; Propylene oxide ; Environmentally friendly
刊名: TETRAHEDRON
发表日期: 2012-09-23
DOI: 10.1016/j.tet.2012.07.004
卷: 68, 期:38, 页:7978-7983
收录类别: SCI ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: MEDIATED SYNTHESIS ; B INHIBITORS ; DERIVATIVES ; EFFICIENT ; 1,3,4-OXADIAZOLES ; ANALOGS ; PHENYL ; DESIGN ; ACID
英文摘要:

It has been developed for the synthesis of substituted-1,3,4-oxadiazole-2(3H)-one derivatives via a novel one-pot, tandem procedure assisted by propylene oxide. The 5-substitued-1,3,4-oxadiazole-2(3H)-ones and 3,5-disubstitued-1,3,4-oxadiazole-2(3H)-ones were, respectively, obtained from three-component reaction of acylhydrazines, carbon disulfide, and propylene oxide, and four-component reaction of acylhydarazines, carbon disulfide, propylene oxide, and organic halides. The reactions were carried out using water as solvent in the presence of potassium phosphate to afford the expected products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 21172011 ; 2009ZX09103-131
项目资助者: National Natural Science Foundation of China ; State Key New Drug Development Program
WOS记录号: WOS:000308051600034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65379
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Yan, Xu,Zhou, Shuo,Wang, Yuanqiang,et al. Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3H)-ones in water[J]. TETRAHEDRON,2012,68(38):7978-7983.
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