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学科主题临床医学
Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases
Wang, Hongyu; Liu, Jinbo; Wang, Qi; Zhao, Hongwei; Shi, Hongyan; Yu, Xiaolan; Fu, Xiaobao
刊名BMJ OPEN
2013
DOI10.1136/bmjopen-2012-002483
3期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]PULSE-WAVE VELOCITY ; ARTERIAL STIFFNESS ; CORONARY-ARTERY ; ENDOTHELIAL FUNCTION ; DIABETES-MELLITUS ; FOLATE THERAPY ; BLOOD-PRESSURE ; FOLIC-ACID ; TETRAHYDROBIOPTERIN ; ATHEROSCLEROSIS
英文摘要

Objectives: Cardioankle vascular index (CAVI) is a new index of arterial stiffness independent of immediate blood pressure. Homocysteine (Hcy) is an independent risk factor for vascular diseases. The aim of this study was to investigate the relationship between Hcy and CAVI in the vascular-related diseases.

Design: Descriptive research.

Participants: 88 patients (M/F 46/42) with or without hypertension, coronary artery disease or arteriosclerosis obliterans were enrolled to our study. They were divided into two groups according to the level of Hcy.

Methods: CAVI, carotid-femoral pulse wave velocity (CF-PWV) and carotid-radial pulse wave velocity (CR-PWV) were measured by VS-1000 and Complior apparatus.

Results: There was significant correlation between Hcy and CF-PWV, CR-PWV, CAVI in the entire group (r=0.33, p=0.002; r=0.51, p<0.001; r=0.42, p<0.001, respectively). And there was significant correlation between Hcy and CF-PWV, CR-PWV, CAVI in the vascular-related disease group (r=0.23, p=0.048; r=0.51, p<0.001; r=0.392, p=0.001, respectively). The level of Hcy was significantly higher in patients with one or more vascular diseases than in patients without vascular diseases. The levels of CF-PWV, CR-PWV and CAVI were significantly higher in Hcy >= 15 mu mol/l group than in Hcy <5 mu mol/l group (13.7 +/- 3.0 vs 10.8 +/- 2.5, p < 0.001; 10.6 +/- 2.1 vs 9.2 +/- 1.6, p=0.001; 9.30 +/- 2.1 vs 7.79 +/- 2.1, p=0.001, respectively). Multiple linear regression showed that Hcy, body mass index (BMI) and age were independent associating factors of CAVI in the entire study group (beta=0.421, p=0.001; beta=-0.309, p=0.006; beta=0.297, p=0.012, respectively). And Hcy, BMI and age were independent influencing factors of CAVI in the vascular-related disease group (beta=0.434, p=0.001; beta=-0.331, p=0.009; beta=0.288, p=0.022, respectively).

Conclusions: CAVI was positively correlated with Hcy in the vascular-related diseases.

语种英语
WOS记录号WOS:000330560500060
项目编号2011-4026-02 ; 2010-Y002 ; 2012Y04
资助机构Capital Health Research and Development of Special ; hospital fund of Peking University Shougang Hospital
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65383
专题北京大学首钢医院_心血管内科
北京大学第一临床医学院_妇产科
作者单位Peking Univ, Dept Vasc Med, Shougang Hosp, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Hongyu,Liu, Jinbo,Wang, Qi,et al. Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases[J]. BMJ OPEN,2013,3(3).
APA Wang, Hongyu.,Liu, Jinbo.,Wang, Qi.,Zhao, Hongwei.,Shi, Hongyan.,...&Fu, Xiaobao.(2013).Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases.BMJ OPEN,3(3).
MLA Wang, Hongyu,et al."Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases".BMJ OPEN 3.3(2013).
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