北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学首钢医院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases
作者: Wang, Hongyu; Liu, Jinbo; Wang, Qi; Zhao, Hongwei; Shi, Hongyan; Yu, Xiaolan; Fu, Xiaobao
刊名: BMJ OPEN
发表日期: 2013
DOI: 10.1136/bmjopen-2012-002483
卷: 3, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PULSE-WAVE VELOCITY ; ARTERIAL STIFFNESS ; CORONARY-ARTERY ; ENDOTHELIAL FUNCTION ; DIABETES-MELLITUS ; FOLATE THERAPY ; BLOOD-PRESSURE ; FOLIC-ACID ; TETRAHYDROBIOPTERIN ; ATHEROSCLEROSIS
英文摘要:

Objectives: Cardioankle vascular index (CAVI) is a new index of arterial stiffness independent of immediate blood pressure. Homocysteine (Hcy) is an independent risk factor for vascular diseases. The aim of this study was to investigate the relationship between Hcy and CAVI in the vascular-related diseases.

Design: Descriptive research.

Participants: 88 patients (M/F 46/42) with or without hypertension, coronary artery disease or arteriosclerosis obliterans were enrolled to our study. They were divided into two groups according to the level of Hcy.

Methods: CAVI, carotid-femoral pulse wave velocity (CF-PWV) and carotid-radial pulse wave velocity (CR-PWV) were measured by VS-1000 and Complior apparatus.

Results: There was significant correlation between Hcy and CF-PWV, CR-PWV, CAVI in the entire group (r=0.33, p=0.002; r=0.51, p<0.001; r=0.42, p<0.001, respectively). And there was significant correlation between Hcy and CF-PWV, CR-PWV, CAVI in the vascular-related disease group (r=0.23, p=0.048; r=0.51, p<0.001; r=0.392, p=0.001, respectively). The level of Hcy was significantly higher in patients with one or more vascular diseases than in patients without vascular diseases. The levels of CF-PWV, CR-PWV and CAVI were significantly higher in Hcy >= 15 mu mol/l group than in Hcy <5 mu mol/l group (13.7 +/- 3.0 vs 10.8 +/- 2.5, p < 0.001; 10.6 +/- 2.1 vs 9.2 +/- 1.6, p=0.001; 9.30 +/- 2.1 vs 7.79 +/- 2.1, p=0.001, respectively). Multiple linear regression showed that Hcy, body mass index (BMI) and age were independent associating factors of CAVI in the entire study group (beta=0.421, p=0.001; beta=-0.309, p=0.006; beta=0.297, p=0.012, respectively). And Hcy, BMI and age were independent influencing factors of CAVI in the vascular-related disease group (beta=0.434, p=0.001; beta=-0.331, p=0.009; beta=0.288, p=0.022, respectively).

Conclusions: CAVI was positively correlated with Hcy in the vascular-related diseases.

语种: 英语
所属项目编号: 2011-4026-02 ; 2010-Y002 ; 2012Y04
项目资助者: Capital Health Research and Development of Special ; hospital fund of Peking University Shougang Hospital
WOS记录号: WOS:000330560500060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65383
Appears in Collections:北京大学首钢医院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Vasc Med, Shougang Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Hongyu,Liu, Jinbo,Wang, Qi,et al. Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases[J]. BMJ OPEN,2013,3(3).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Hongyu]'s Articles
[Liu, Jinbo]'s Articles
[Wang, Qi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Hongyu]‘s Articles
[Liu, Jinbo]‘s Articles
[Wang, Qi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace