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Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis
Wang, Bang1,2; Xiong, De-Cai1,2; Ye, Xin-Shan1,2
刊名ORGANIC LETTERS
2015-11-20
DOI10.1021/acs.orglett.5b03016
17期:22页:5698-5701
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]Radical Trifluoromethylation ; Hemagglutinin-neuraminidase ; Medicinal Chemistry ; Continuous-flow ; Recent Progress ; D-glucose ; Light ; Derivatives ; Alkenes ; Fluorine
英文摘要

A Mild, efficient, and practical transformation for the direct C-H,trifluotoni-ethylation:of glycals under visible light has been reported for the first time This reaction employed fac-Ir3+ (ppy)(3) as the photocatalyst) Urnemo′s reagent as the CF3 source, and a household blue Letp or sunlight as the light source. Glycals bearing both withdrawing and -donating protective groups performed this reaction smoothly: This visible ligilit-mediated trifluomethylation reaction was highlighted by the trifluoromethlyation of the biologically important Neu2en moiety.

语种英语
WOS记录号WOS:000365462900047
通讯作者邮箱decai@bjmu.edu.cn
项目编号2012CB822100 ; 2013CB910700 ; 21232002 ; YETP0063
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Higher Education Young Elite Teacher Project
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65384
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_药物化学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Mol & Translat Med, Beijing 100191, Peoples R China
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GB/T 7714
Wang, Bang,Xiong, De-Cai,Ye, Xin-Shan. Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis[J]. ORGANIC LETTERS,2015,17(22):5698-5701.
APA Wang, Bang,Xiong, De-Cai,&Ye, Xin-Shan.(2015).Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis.ORGANIC LETTERS,17(22),5698-5701.
MLA Wang, Bang,et al."Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis".ORGANIC LETTERS 17.22(2015):5698-5701.
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