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学科主题临床医学
Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation
Yu, Nengwang1; Fu, Shuai2; Liu, Yibao1; Fu, Zhihou3; Meng, Jianzhong4; Xu, Zhonghua5; Wang, Baocheng6; Zhang, Aimin1
刊名PLOS ONE
2013-12-09
DOI10.1371/journal.pone.0081745
8期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]RESTORED KIDNEYS ; TUMOR NECROSIS ; TRANSPLANTATION ; CARCINOMA ; SURVIVAL ; DIALYSIS ; EXCISION ; DONORS ; IMPACT
英文摘要

The worry of potential residual renal cancer cells in donor kidney after resection of small renal cancer impedes the extensive use of such controversial donor source. To explore the impacts of organ preservation process on the survival of renal cancer cells, we detected cell proliferation and viability of benign and malignant renal cell lines and clinical renal samples after treated with simulated organ preservation process. It was found that the viability and proliferation of malignant renal cells are inhibited much more than that of benign renal cells during prolonged organ preservation. The inhibition of proliferation in benign renal cells is fully reversible, while in malignant renal cancer cells is not fully reversible after a certain time. So potential residual renal cancer cells could be partly inhibited and eliminated by organ preservation process.

语种英语
WOS记录号WOS:000328705200047
项目编号2012M521931
资助机构China Postdoctoral Science Foundation
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65390
专题北京大学临床肿瘤学院_胸部肿瘤内科
作者单位1.Jinan Mil Command, Gen Hosp, Dept Oncol, Jinan, Shandong, Peoples R China
2.Beijing Canc Hosp, Dept Thorac Med Oncol, Beijing, Peoples R China
3.Jinan Mil Command, Gen Hosp, Dept Orthoped, Jinan, Shandong, Peoples R China
4.Jinan Mil Command, Gen Hosp, Blood Purificat Dept, Jinan, Shandong, Peoples R China
5.Jinan Mil Command, Gen Hosp, Dept Urol, Jinan, Shandong, Peoples R China
6.Qilu Hosp, Dept Urol, Jinan, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Yu, Nengwang,Fu, Shuai,Liu, Yibao,et al. Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation[J]. PLOS ONE,2013,8(12).
APA Yu, Nengwang.,Fu, Shuai.,Liu, Yibao.,Fu, Zhihou.,Meng, Jianzhong.,...&Zhang, Aimin.(2013).Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation.PLOS ONE,8(12).
MLA Yu, Nengwang,et al."Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation".PLOS ONE 8.12(2013).
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