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学科主题: 临床医学
题名:
Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation
作者: Yu, Nengwang1; Fu, Shuai2; Liu, Yibao1; Fu, Zhihou3; Meng, Jianzhong4; Xu, Zhonghua5; Wang, Baocheng6; Zhang, Aimin1
刊名: PLOS ONE
发表日期: 2013-12-09
DOI: 10.1371/journal.pone.0081745
卷: 8, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RESTORED KIDNEYS ; TUMOR NECROSIS ; TRANSPLANTATION ; CARCINOMA ; SURVIVAL ; DIALYSIS ; EXCISION ; DONORS ; IMPACT
英文摘要:

The worry of potential residual renal cancer cells in donor kidney after resection of small renal cancer impedes the extensive use of such controversial donor source. To explore the impacts of organ preservation process on the survival of renal cancer cells, we detected cell proliferation and viability of benign and malignant renal cell lines and clinical renal samples after treated with simulated organ preservation process. It was found that the viability and proliferation of malignant renal cells are inhibited much more than that of benign renal cells during prolonged organ preservation. The inhibition of proliferation in benign renal cells is fully reversible, while in malignant renal cancer cells is not fully reversible after a certain time. So potential residual renal cancer cells could be partly inhibited and eliminated by organ preservation process.

语种: 英语
所属项目编号: 2012M521931
项目资助者: China Postdoctoral Science Foundation
WOS记录号: WOS:000328705200047
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65390
Appears in Collections:北京大学临床肿瘤学院_胸部肿瘤内科_期刊论文

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作者单位: 1.Jinan Mil Command, Gen Hosp, Dept Oncol, Jinan, Shandong, Peoples R China
2.Beijing Canc Hosp, Dept Thorac Med Oncol, Beijing, Peoples R China
3.Jinan Mil Command, Gen Hosp, Dept Orthoped, Jinan, Shandong, Peoples R China
4.Jinan Mil Command, Gen Hosp, Blood Purificat Dept, Jinan, Shandong, Peoples R China
5.Jinan Mil Command, Gen Hosp, Dept Urol, Jinan, Shandong, Peoples R China
6.Qilu Hosp, Dept Urol, Jinan, Shandong, Peoples R China

Recommended Citation:
Yu, Nengwang,Fu, Shuai,Liu, Yibao,et al. Benign and Malignant Renal Cells Are Differentially Inhibited during Prolonged Organ Preservation[J]. PLOS ONE,2013,8(12).
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