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学科主题临床医学
Presence of Concomitant Non-muscle-invasive Bladder Cancer in Chinese Patients with Upper Tract Urothelial Carcinoma: Risk Factors, Characteristics, and Predictive Value
Fang, Dong1; Zhang, Lei1; Li, Xuesong1; Yu, Wei1; Singla, Nirmish2; Zhao, Guangzhi1; Xiong, Gengyan1; Song, Yi1; He, Qun1; He, Zhisong1; Zhou, Liqun1
刊名ANNALS OF SURGICAL ONCOLOGY
2015-08-01
DOI10.1245/s10434-014-4302-5
22期:8页:2789-2798
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
研究领域[WOS]Oncology ; Surgery
关键词[WOS]UPPER URINARY-TRACT ; TRANSITIONAL-CELL CARCINOMA ; RADICAL NEPHROURETERECTOMY ; PROGNOSTIC-SIGNIFICANCE ; TUMOR HISTORY ; OUTCOMES ; LOCATION ; RECURRENCE ; EXPERIENCE ; SURVIVAL
英文摘要

To explore the characteristics, predictive risk factors, and prognostic effect of concomitant non-muscle-invasive bladder cancer (NMIBC) in patients with upper tract urothelial carcinoma (UTUC).

We evaluated 727 consecutive UTUC patients treated with radical resection between 2000 and 2012 in a high-volume center of China. Preoperative cystoscopy was performed in all patients. Patients with previous or concomitant total cystectomy were excluded.

Overall, 73 patients (10.0 %) had NMIBC. Concomitant NMIBC was associated with previous bladder cancer (p = 0.003), tumor located in ureter (p = 0.008), multifocality (p < 0.001), and preoperative renal insufficiency (p = 0.023). The presence of concomitant NMIBC was predictive for lower tumor stage (p = 0.019), papillary architecture (p = 0.023), and organ-confined disease (pT < 3 and N-, p = 0.006). The median follow-up duration was 57 months. The presence of concomitant NMIBC was a risk factor for bladder recurrence (p < 0.001), and particularly in patients with non-muscle-invasive UTUCs, it affects cancer-specific survival (odds ratio 1.614, p = 0.030) and contralateral recurrence (odds ratio, 1.907, p = 0.016). Most concomitant NMIBC were found at the lateral wall or bladder neck, while most intravesical recurrences occurred near the site of surgery or posterior wall.

The most common site for concomitant NMIBC was lateral wall and bladder neck, and previous bladder cancer, tumor located in ureter, tumor multifocality, and preoperative renal insufficiency were risk factors for concomitant NMIBC. The presence of concomitant NMIBC is predictive for relative better pathologic outcomes but higher rate of bladder recurrence, while the effect on postoperative survival was limited with patients early-stage UTUCs. The potential mechanisms need further investigation.

语种英语
WOS记录号WOS:000358734300046
项目编号BMU20120318 ; 7122183 ; 81172419 ; 81372746
资助机构Collaborative Research Foundation of Peking University Health Science Center ; National Taiwan University, the College of Medicine ; Natural Science Foundation of Beijing ; Natural Science Foundation of China ; Research Foundation of Peking University First Hospital
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65394
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Dept Urol, Inst Urol,Natl Urol Canc Ctr, Beijing 100871, Peoples R China
2.Univ Texas SW Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA
推荐引用方式
GB/T 7714
Fang, Dong,Zhang, Lei,Li, Xuesong,et al. Presence of Concomitant Non-muscle-invasive Bladder Cancer in Chinese Patients with Upper Tract Urothelial Carcinoma: Risk Factors, Characteristics, and Predictive Value[J]. ANNALS OF SURGICAL ONCOLOGY,2015,22(8):2789-2798.
APA Fang, Dong.,Zhang, Lei.,Li, Xuesong.,Yu, Wei.,Singla, Nirmish.,...&Zhou, Liqun.(2015).Presence of Concomitant Non-muscle-invasive Bladder Cancer in Chinese Patients with Upper Tract Urothelial Carcinoma: Risk Factors, Characteristics, and Predictive Value.ANNALS OF SURGICAL ONCOLOGY,22(8),2789-2798.
MLA Fang, Dong,et al."Presence of Concomitant Non-muscle-invasive Bladder Cancer in Chinese Patients with Upper Tract Urothelial Carcinoma: Risk Factors, Characteristics, and Predictive Value".ANNALS OF SURGICAL ONCOLOGY 22.8(2015):2789-2798.
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