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GC-TOF-MS-based serum metabolomic investigations of naked oat bran supplementation in high-fat-diet-induced dyslipidemic rats
Gu, Jiaojiao1; Jing, Lulu1; Ma, Xiaotao1,2; Zhang, Zhaofeng1; Guo, Qianying1; Li, Yong1
关键词Oat bran Dyslipidemia Metabolomics High-fat diet Gas chromatography quadrupole-time-of-flight mass spectrometry
刊名JOURNAL OF NUTRITIONAL BIOCHEMISTRY
2015-12-01
DOI10.1016/j.jnutbio.2015.07.019
26期:12页:1509-1519
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Nutrition & Dietetics
研究领域[WOS]Biochemistry & Molecular Biology ; Nutrition & Dietetics
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; CORONARY-HEART-DISEASE ; BETA-GLUCAN ; LIPID PROFILE ; CHOLESTEROL ; ACID ; OVERWEIGHT ; ADULTS ; FIBER ; RISK
英文摘要

The present study aimed to explore the metabolic response of oat bran consumption in dyslipidemic rats by a high-throughput metabolomics approach. Four groups of Sprague-Dawley rats were used: N group (normal chow diet), M group (dyslipidemia induced by 4-week high-fat feeding, then normal chow diet), OL group and OH group (dyslipidemia induced, then normal chow diet supplemented with 10.8% or 43.4% naked oat bran). Intervention lasted for 12 weeks. Gas chromatography quadrupole time-of-flight mass spectrometry was used to identify serum metabolite profiles. Results confirmed the effects of oat bran on improving lipidemic variables and showed distinct metabolomic profiles associated with diet intervention. A number of endogenous molecules were changed by high-fat diet and normalized following supplementation of naked oat bran. Elevated levels of serum unsaturated fatty acids including arachidonic acid (Log2Fold of change=0.70, P=.02 OH vs. M group), palmitoleic acid (Log2Fold of change-=1.24, P=.02 OH vs. M group) and oleic acid (Log2Fold of change=0.66, P=.04 OH vs. M group) were detected after oat bran consumption. Furthermore, consumption of oat bran was also characterized by higher levels of methionine and S-adenosylmethionine. Pathway exploration found that most of the discriminant metabolites were involved in fatty acid biosynthesis, biosynthesis and metabolism of amino acids, microbial metabolism in diverse environments and biosynthesis of plant secondary metabolites. These results point to potential biomarkers and underlying benefit of naked oat bran in the context of diet-induced dyslipidemia and offer some insights into the mechanism exploration. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000366785600012
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65395
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
2.China Japan Friendship Hosp, Dept Nutr, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Gu, Jiaojiao,Jing, Lulu,Ma, Xiaotao,et al. GC-TOF-MS-based serum metabolomic investigations of naked oat bran supplementation in high-fat-diet-induced dyslipidemic rats[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2015,26(12):1509-1519.
APA Gu, Jiaojiao,Jing, Lulu,Ma, Xiaotao,Zhang, Zhaofeng,Guo, Qianying,&Li, Yong.(2015).GC-TOF-MS-based serum metabolomic investigations of naked oat bran supplementation in high-fat-diet-induced dyslipidemic rats.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,26(12),1509-1519.
MLA Gu, Jiaojiao,et al."GC-TOF-MS-based serum metabolomic investigations of naked oat bran supplementation in high-fat-diet-induced dyslipidemic rats".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 26.12(2015):1509-1519.
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