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学科主题: 公共卫生
题名:
GC-TOF-MS-based serum metabolomic investigations of naked oat bran supplementation in high-fat-diet-induced dyslipidemic rats
作者: Gu, Jiaojiao1; Jing, Lulu1; Ma, Xiaotao1,2; Zhang, Zhaofeng1; Guo, Qianying1; Li, Yong1
关键词: Oat bran ; Dyslipidemia ; Metabolomics ; High-fat diet ; Gas chromatography quadrupole-time-of-flight mass spectrometry
刊名: JOURNAL OF NUTRITIONAL BIOCHEMISTRY
发表日期: 2015-12-01
DOI: 10.1016/j.jnutbio.2015.07.019
卷: 26, 期:12, 页:1509-1519
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Nutrition & Dietetics
研究领域[WOS]: Biochemistry & Molecular Biology ; Nutrition & Dietetics
关键词[WOS]: RANDOMIZED CONTROLLED-TRIAL ; CORONARY-HEART-DISEASE ; BETA-GLUCAN ; LIPID PROFILE ; CHOLESTEROL ; ACID ; OVERWEIGHT ; ADULTS ; FIBER ; RISK
英文摘要:

The present study aimed to explore the metabolic response of oat bran consumption in dyslipidemic rats by a high-throughput metabolomics approach. Four groups of Sprague-Dawley rats were used: N group (normal chow diet), M group (dyslipidemia induced by 4-week high-fat feeding, then normal chow diet), OL group and OH group (dyslipidemia induced, then normal chow diet supplemented with 10.8% or 43.4% naked oat bran). Intervention lasted for 12 weeks. Gas chromatography quadrupole time-of-flight mass spectrometry was used to identify serum metabolite profiles. Results confirmed the effects of oat bran on improving lipidemic variables and showed distinct metabolomic profiles associated with diet intervention. A number of endogenous molecules were changed by high-fat diet and normalized following supplementation of naked oat bran. Elevated levels of serum unsaturated fatty acids including arachidonic acid (Log2Fold of change=0.70, P=.02 OH vs. M group), palmitoleic acid (Log2Fold of change-=1.24, P=.02 OH vs. M group) and oleic acid (Log2Fold of change=0.66, P=.04 OH vs. M group) were detected after oat bran consumption. Furthermore, consumption of oat bran was also characterized by higher levels of methionine and S-adenosylmethionine. Pathway exploration found that most of the discriminant metabolites were involved in fatty acid biosynthesis, biosynthesis and metabolism of amino acids, microbial metabolism in diverse environments and biosynthesis of plant secondary metabolites. These results point to potential biomarkers and underlying benefit of naked oat bran in the context of diet-induced dyslipidemia and offer some insights into the mechanism exploration. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000366785600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65395
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
2.China Japan Friendship Hosp, Dept Nutr, Beijing 100029, Peoples R China

Recommended Citation:
Gu, Jiaojiao,Jing, Lulu,Ma, Xiaotao,et al. GC-TOF-MS-based serum metabolomic investigations of naked oat bran supplementation in high-fat-diet-induced dyslipidemic rats[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2015,26(12):1509-1519.
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