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学科主题: 基础医学
题名:
Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric beta-amyloid 1-42-induced neurotoxicity
作者: Dai, Xueling1,2,3; Chang, Ping1,3; Zhu, Qingzhu1; Liu, Wenjuan1,3; Sun, Yaxuan1; Zhu, Shigong2; Jiang, Zhaofeng1,3
关键词: Alzheimer&prime ; s disease ; beta-Amyloid peptide ; Chitosan oligosaccharides ; Neurotoxicity
刊名: NEUROSCIENCE LETTERS
发表日期: 2013-10-25
DOI: 10.1016/j.neulet.2013.08.046
卷: 554, 页:64-69
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; APOPTOSIS ; CELLS ; INHIBITION ; PEPTIDE ; MICE ; ACTIVATION ; CASPASES ; PATHWAY
英文摘要:

beta-Amyloid peptide (A beta), the major component of senile plaques in patients with Alzheimer′s disease (AD), is believed to facilitate the progressive neurodegeneration that occurs in this disease. Mounting natural compounds are proved to be potential candidates for the prevention and treatment of AD. Chitosan oligosaccharides (COSs), the enzymatic hydrolysates of chitosan, have been reported to possess diverse biological activities. Here we investigated the effect of COSs on oligomeric A beta-mediated toxicity in rat primary hippocampal neurons. Pretreatment with COSs markedly inhibited cell death induced by A beta exposure as determined by cell viability assay and lactate dehydrogenase release assay. In parallel, the generation of reactive oxygen species and lipid peroxidation were attenuated by COSs. Furthermore, our results indicated that COSs remarkably prevented A beta-induced cell apoptosis as manifested by depressing the elevation of Bax/Bcl-2 ratio and caspase-3 activation, suggesting that the neuroprotective effect of COSs could be partially due to apoptosis regulation. In addition, pretreatment with COSs significantly blocked A beta-induced phosphorylation of c-Jun N-terminal kinase. Taken together, these findings may shed light on the role of COSs as a potential therapeutic agent for AD. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 31071512 ; SQKM 201211417013
项目资助者: NSFC ; Scientific Research Common Program of Beijing Municipal Commission of Education
WOS记录号: WOS:000327674600013
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65404
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Beijing Union Univ, Res Inst Sci & Technol Funct Food, Beijing 100191, Peoples R China

Recommended Citation:
Dai, Xueling,Chang, Ping,Zhu, Qingzhu,et al. Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric beta-amyloid 1-42-induced neurotoxicity[J]. NEUROSCIENCE LETTERS,2013,554:64-69.
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