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Biologically-Targeted Detection of Primary and Micro-Metastatic Ovarian Cancer
Liu, Tracy W.1; Stewart, Jocelyn M.1; MacDonald, Thomas D.2; Chen, Juan1; Clarke, Blaise3; Shi, Jiyun1,4; Wilson, Brian C.1; Neel, Benjamin G.1; Zheng, Gang1
关键词Ovarian Cancer Folate Receptor PET fluorescence imaging multimodal
刊名THERANOSTICS
2013
DOI10.7150/thno.6413
3期:6页:420-427
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]FOLATE RECEPTOR-ALPHA ; PHOTODYNAMIC THERAPY ; THERANOSTIC AGENT ; PET ; INTRAPERITONEAL ; TRIAL
英文摘要

Ovarian cancer is the leading cause of morbidity/mortality from gynecologic malignancy. Early detection of disease is difficult due to the propensity for ovarian cancer to disseminate throughout the peritoneum. Currently, there is no single accurate test to detect primary or recurrent ovarian cancer. We report a novel clinical strategy using PPF: a multimodal, PET and optical, folate receptor (FR)-targeted agent for ovarian cancer imaging. The capabilities of PPF were evaluated in primary human ovarian cancer cells, in vivo xenografts derived from primary cells and ex vivo patient omemtum, as the heterogeneity and phenotype displayed by patients is retained. Primary cells uptake PPF in a FR-dependent manner demonstrating approximately a 5- to 25-fold increase in fluorescence. By both PET and fluorescence imaging, PPF specifically delineated FR-positive, ovarian cancer xenografts, with similar tumor-to-background ratios of 8.91 +/- 0.91 and 7.94 +/- 3.94, and micro-metastatic studding (<1mm), which demonstrated a 3.5-fold increase in PPF uptake over adjacent normal tissue. Ex vivo patient omentum demonstrated selective uptake of PFF by tumor deposits. The ability of PPF to identify metastatic deposits <1mm could facilitate more complete debulking (currently, optimal debulking is <10mm residual tumor), by providing a more sensitive imaging strategy improving treatment planning, response assessment and residual/recurrent disease detection. Therefore, PPF is a novel clinical imaging strategy that could substantially improve the prognosis of patients with ovarian cancer by allowing pre-, post- and intra-operative tumor monitoring, detection and possibly treatment throughout all stages of therapy and tumor progression.

语种英语
WOS记录号WOS:000321058100006
项目编号020003 ; CIHR-CGS-200710MDR ; W81XWH-10-1-0115
资助机构Canadian Institute for Health Research ; Princess Margaret Hospital Foundation ; Joey and Toby Tanenbam/Brazilian Ball Chair in Prostate Cancer Research ; Terry Fox Foundation (Canadian Cancer Society Research Institute - Terry Fox Program) ; Samuel Waxman Cancer Research Foundation ; Canadian Graduate Scholarship Canadian Institute for Health research ; Department of Defense BCRP Predoctoral Award
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65406
专题北京大学医药卫生分析中心
作者单位1.Univ Toronto, Dept Pharmaceut Sci, Toronto, ON, Canada
2.Univ Hlth Network, Dept Pathol, Toronto, ON, Canada
3.Univ Toronto, Dept Med Biophys, Princess Margarete Canc Ctr, Toronto, ON, Canada
4.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Tracy W.,Stewart, Jocelyn M.,MacDonald, Thomas D.,et al. Biologically-Targeted Detection of Primary and Micro-Metastatic Ovarian Cancer[J]. THERANOSTICS,2013,3(6):420-427.
APA Liu, Tracy W..,Stewart, Jocelyn M..,MacDonald, Thomas D..,Chen, Juan.,Clarke, Blaise.,...&Zheng, Gang.(2013).Biologically-Targeted Detection of Primary and Micro-Metastatic Ovarian Cancer.THERANOSTICS,3(6),420-427.
MLA Liu, Tracy W.,et al."Biologically-Targeted Detection of Primary and Micro-Metastatic Ovarian Cancer".THERANOSTICS 3.6(2013):420-427.
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