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学科主题: 公共卫生
题名:
Biologically-Targeted Detection of Primary and Micro-Metastatic Ovarian Cancer
作者: Liu, Tracy W.1; Stewart, Jocelyn M.1; MacDonald, Thomas D.2; Chen, Juan1; Clarke, Blaise3; Shi, Jiyun1,4; Wilson, Brian C.1; Neel, Benjamin G.1; Zheng, Gang1
关键词: Ovarian Cancer ; Folate Receptor ; PET ; fluorescence imaging ; multimodal
刊名: THERANOSTICS
发表日期: 2013
DOI: 10.7150/thno.6413
卷: 3, 期:6, 页:420-427
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: FOLATE RECEPTOR-ALPHA ; PHOTODYNAMIC THERAPY ; THERANOSTIC AGENT ; PET ; INTRAPERITONEAL ; TRIAL
英文摘要:

Ovarian cancer is the leading cause of morbidity/mortality from gynecologic malignancy. Early detection of disease is difficult due to the propensity for ovarian cancer to disseminate throughout the peritoneum. Currently, there is no single accurate test to detect primary or recurrent ovarian cancer. We report a novel clinical strategy using PPF: a multimodal, PET and optical, folate receptor (FR)-targeted agent for ovarian cancer imaging. The capabilities of PPF were evaluated in primary human ovarian cancer cells, in vivo xenografts derived from primary cells and ex vivo patient omemtum, as the heterogeneity and phenotype displayed by patients is retained. Primary cells uptake PPF in a FR-dependent manner demonstrating approximately a 5- to 25-fold increase in fluorescence. By both PET and fluorescence imaging, PPF specifically delineated FR-positive, ovarian cancer xenografts, with similar tumor-to-background ratios of 8.91 +/- 0.91 and 7.94 +/- 3.94, and micro-metastatic studding (<1mm), which demonstrated a 3.5-fold increase in PPF uptake over adjacent normal tissue. Ex vivo patient omentum demonstrated selective uptake of PFF by tumor deposits. The ability of PPF to identify metastatic deposits <1mm could facilitate more complete debulking (currently, optimal debulking is <10mm residual tumor), by providing a more sensitive imaging strategy improving treatment planning, response assessment and residual/recurrent disease detection. Therefore, PPF is a novel clinical imaging strategy that could substantially improve the prognosis of patients with ovarian cancer by allowing pre-, post- and intra-operative tumor monitoring, detection and possibly treatment throughout all stages of therapy and tumor progression.

语种: 英语
所属项目编号: 020003 ; CIHR-CGS-200710MDR ; W81XWH-10-1-0115
项目资助者: Canadian Institute for Health Research ; Princess Margaret Hospital Foundation ; Joey and Toby Tanenbam/Brazilian Ball Chair in Prostate Cancer Research ; Terry Fox Foundation (Canadian Cancer Society Research Institute - Terry Fox Program) ; Samuel Waxman Cancer Research Foundation ; Canadian Graduate Scholarship Canadian Institute for Health research ; Department of Defense BCRP Predoctoral Award
WOS记录号: WOS:000321058100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65406
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Univ Toronto, Dept Pharmaceut Sci, Toronto, ON, Canada
2.Univ Hlth Network, Dept Pathol, Toronto, ON, Canada
3.Univ Toronto, Dept Med Biophys, Princess Margarete Canc Ctr, Toronto, ON, Canada
4.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Tracy W.,Stewart, Jocelyn M.,MacDonald, Thomas D.,et al. Biologically-Targeted Detection of Primary and Micro-Metastatic Ovarian Cancer[J]. THERANOSTICS,2013,3(6):420-427.
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