学科主题基础医学
Astragaloside IV Protects Heart from Ischemia and Reperfusion Injury via Energy Regulation Mechanisms
Tu, Lei1,2; Pan, Chun-Shui1,3,4; Wei, Xiao-Hong1; Yan, Li1,3,4; Liu, Yu-Ying1,3,4; Fan, Jing-Yu3; Mu, Hong-Na1,2; Li, Quan1,3,4; Li, Lin1; Zhang, Yu1,2; He, Ke1,2; Mao, Xiao-Wei1,2; Sun, Kai1,3,4; Wang, Chuan-She1,2,3,4; Yin, Chang-Cheng5; Han, Jing-Yan1,2,3,4
关键词energy metabolism cardiac function myocardial structure ATP 5D
刊名MICROCIRCULATION
2013-11-01
DOI10.1111/micc.12074
20期:8页:736-747
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]MASS SPECTROMETRY ; RAT PLASMA ; ATP ; PHOSPHORYLATION ; CONTRACTURE ; CALCIUM ; PCI
英文摘要

ObjectiveThis study was designed to investigate the protective potential of AS-IV against ischemia and I/R-induced myocardial damage, with focusing on possible involvement of energy metabolism modulation in its action and the time phase in which it takes effect.

MethodsSD rats were subjected to 30minutes LADCA occlusion, followed by reperfusion. MBF, myocardial infarct size, and cardiac function were evaluated. Myocardial structure and myocardial apoptosis were assessed by double immunofluorescence staining of F-actin and TUNEL. Content of ATP, ADP, and AMP in myocardium, cTnI level, expression of ATP5D, P-MLC2, and apoptosis-related molecules were determined.

ResultsPretreatment with AS-IV suppressed MBF decrease, myocardial cell apoptosis, and myocardial infarction induced by I/R. Moreover, ischemia and I/R both caused cardiac malfunction, decrease in the ratio of ATP/ADP and ATP/AMP, accompanying with reduction of ATP 5D protein and mRNA, and increase in P-MLC2 and serum cTnI, all of which were significantly alleviated by pretreatment with AS-IV, even early in ischemia phase for the insults that were implicated in energy metabolism.

ConclusionsAS-IV prevents I/R-induced cardiac malfunction, maintains the integrity of myocardial structure through regulating energy metabolism. The beneficial effect of AS-IV on energy metabolism initiates during the phase of ischemia.

语种英语
WOS记录号WOS:000326607600010
项目编号81273637
资助机构National Natural Science Foundation of China
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65419
专题北京大学基础医学院_北大医学部天士力微循环研究中心
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
3.State Adm Tradit Chinese Med Peoples Republ China, Key Lab Microcirculat, Beijing, Peoples R China
4.State Adm Tradit Chinese Med Peoples Republ China, Key Lab Stasis & Phlegm, Beijing, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Biophys, Beijing 100191, Peoples R China
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GB/T 7714
Tu, Lei,Pan, Chun-Shui,Wei, Xiao-Hong,et al. Astragaloside IV Protects Heart from Ischemia and Reperfusion Injury via Energy Regulation Mechanisms[J]. MICROCIRCULATION,2013,20(8):736-747.
APA Tu, Lei.,Pan, Chun-Shui.,Wei, Xiao-Hong.,Yan, Li.,Liu, Yu-Ying.,...&Han, Jing-Yan.(2013).Astragaloside IV Protects Heart from Ischemia and Reperfusion Injury via Energy Regulation Mechanisms.MICROCIRCULATION,20(8),736-747.
MLA Tu, Lei,et al."Astragaloside IV Protects Heart from Ischemia and Reperfusion Injury via Energy Regulation Mechanisms".MICROCIRCULATION 20.8(2013):736-747.
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