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The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats
Liang, Jing; Li, Yijing; Ping, Xingjie; Yu, Peng; Zuo, Yanfang; Wu, Liuzhen; Han, Ji-Sheng; Cui, Cailian
关键词morphine conditioned place preference (CPP) opioid receptors nucleus accumbens (NAc)
刊名PEPTIDES
2006-12-01
DOI10.1016/j.peptides.2006.08.011
27期:12页:3307-3314
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]CONDITIONED PLACE PREFERENCE ; PERIAQUEDUCTAL GRAY-MATTER ; NUCLEUS-ACCUMBENS ; DOPAMINE RELEASE ; MOTIVATIONAL PROPERTIES ; METHIONINE-ENKEPHALIN ; OPIATE REWARD ; BRAIN ; STIMULATION ; ACTIVATION
英文摘要

Previous studies suggested that electroacupuncture (EA) can suppress opioid dependence by the release of endogenous opioid peptides. To explore the site of action and the receptors involved, we tried to inject highly specific agonists for mu-, delta- and kappa-opioid receptors into the CNS to test whether it can suppress morphine-induced conditioned place preference (CPP) in the rat. Male Sprague-Dawley rats were trained with 4 mg/kg morphine, i.p. for 4 days to establish the CPP model. This CPP can be prevented by (a) i.p. injection of 3 mg/kg dose of morphine, (b) intracerebroventricular (i.c.v.) injection of micrograms doses of the selective L-opioid receptor agonist DAMGO, delta-agonist DPDPE or kappa-agonist U-50,488H or (c) microinjection of DAMGO, DPDPE or U50488H into the shell of the nucleus accumbens (NAc). The results suggest that the release of endogenous mu-, delta- and kappa-opioid agonists in the NAc shell may play a role for EA suppression of opiate addiction. (c) 2006 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000242821300035
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65420
专题北京大学基础医学院_神经生物学系
作者单位1.Minist Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Key Lab Neurosci, Neurosci Res Inst,Minist Educ, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Hlth Sci, Key Lab Neurosci, Dept Neurobiol,Minist Educ, Beijing 100083, Peoples R China
4.Harvard Univ, Sch Med, Bioorgan & Nat Prod Lab, McLean Hosp, Belmont, MA 02478 USA
推荐引用方式
GB/T 7714
Liang, Jing,Li, Yijing,Ping, Xingjie,et al. The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats[J]. PEPTIDES,2006,27(12):3307-3314.
APA Liang, Jing.,Li, Yijing.,Ping, Xingjie.,Yu, Peng.,Zuo, Yanfang.,...&Cui, Cailian.(2006).The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats.PEPTIDES,27(12),3307-3314.
MLA Liang, Jing,et al."The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats".PEPTIDES 27.12(2006):3307-3314.
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