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学科主题: 基础医学
题名:
The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats
作者: Liang, Jing; Li, Yijing; Ping, Xingjie; Yu, Peng; Zuo, Yanfang; Wu, Liuzhen; Han, Ji-Sheng; Cui, Cailian
关键词: morphine ; conditioned place preference (CPP) ; opioid receptors ; nucleus accumbens (NAc)
刊名: PEPTIDES
发表日期: 2006-12-01
DOI: 10.1016/j.peptides.2006.08.011
卷: 27, 期:12, 页:3307-3314
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; PERIAQUEDUCTAL GRAY-MATTER ; NUCLEUS-ACCUMBENS ; DOPAMINE RELEASE ; MOTIVATIONAL PROPERTIES ; METHIONINE-ENKEPHALIN ; OPIATE REWARD ; BRAIN ; STIMULATION ; ACTIVATION
英文摘要:

Previous studies suggested that electroacupuncture (EA) can suppress opioid dependence by the release of endogenous opioid peptides. To explore the site of action and the receptors involved, we tried to inject highly specific agonists for mu-, delta- and kappa-opioid receptors into the CNS to test whether it can suppress morphine-induced conditioned place preference (CPP) in the rat. Male Sprague-Dawley rats were trained with 4 mg/kg morphine, i.p. for 4 days to establish the CPP model. This CPP can be prevented by (a) i.p. injection of 3 mg/kg dose of morphine, (b) intracerebroventricular (i.c.v.) injection of micrograms doses of the selective L-opioid receptor agonist DAMGO, delta-agonist DPDPE or kappa-agonist U-50,488H or (c) microinjection of DAMGO, DPDPE or U50488H into the shell of the nucleus accumbens (NAc). The results suggest that the release of endogenous mu-, delta- and kappa-opioid agonists in the NAc shell may play a role for EA suppression of opiate addiction. (c) 2006 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000242821300035
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65420
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Minist Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Key Lab Neurosci, Neurosci Res Inst,Minist Educ, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Hlth Sci, Key Lab Neurosci, Dept Neurobiol,Minist Educ, Beijing 100083, Peoples R China
4.Harvard Univ, Sch Med, Bioorgan & Nat Prod Lab, McLean Hosp, Belmont, MA 02478 USA

Recommended Citation:
Liang, Jing,Li, Yijing,Ping, Xingjie,et al. The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats[J]. PEPTIDES,2006,27(12):3307-3314.
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