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学科主题: 临床医学
题名:
Synthesis of a quinazoline derivative: A new alpha(1)-adrenoceptor ligand for conjugation to quantum dots to study alpha(1)-adrenoceptors in living cells
作者: Zhou, Guoheng2; Wang, Lei1; Ma, Yudao2; Wang, Liping1; Zhang, Youyi3; Jiang, Wei2
关键词: Quantum dot ; Fluorescent probe ; alpha(1)-Adrenoceptor ; Quinazoline ; Adrenoceptor antagonist
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2011-10-01
DOI: 10.1016/j.bmcl.2011.07.122
卷: 21, 期:19, 页:5905-5909
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: IN-VIVO ; ANTIBODY ; RECEPTORS ; PRAZOSIN ; BINDING ; PROBES
英文摘要:

Quantum dots (QDs) that are conjugated to small molecule derivatives of drugs and endogenous ligands may be useful tools to study the distribution and dynamic of membrane bound receptors, ion channels and transporters in live cells. In order to use these tools, it is necessary to functionalize QDs with bioactive ligands. In this paper, we successfully synthesized a ligand of alpha(1)-adrenoceptor that could be conjugated to QDs. In addition, the conjugation of the ligands to QDs and their biological activity were evaluated through binding assay with 30 nM QD conjugates in living human embryonic kidney 293 cells. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 20775043 ; 20875056 ; Z2008B05
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province in China
WOS记录号: WOS:000294714400053
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65421
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Shandong Univ, Sch Pharm, Jinan 250012, Shandong, Peoples R China
2.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China
3.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Guoheng,Wang, Lei,Ma, Yudao,et al. Synthesis of a quinazoline derivative: A new alpha(1)-adrenoceptor ligand for conjugation to quantum dots to study alpha(1)-adrenoceptors in living cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(19):5905-5909.
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