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Synthesis of a quinazoline derivative: A new alpha(1)-adrenoceptor ligand for conjugation to quantum dots to study alpha(1)-adrenoceptors in living cells
Zhou, Guoheng2; Wang, Lei1; Ma, Yudao2; Wang, Liping1; Zhang, Youyi3; Jiang, Wei2
关键词Quantum dot Fluorescent probe alpha(1)-Adrenoceptor Quinazoline Adrenoceptor antagonist
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2011-10-01
DOI10.1016/j.bmcl.2011.07.122
21期:19页:5905-5909
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]IN-VIVO ; ANTIBODY ; RECEPTORS ; PRAZOSIN ; BINDING ; PROBES
英文摘要

Quantum dots (QDs) that are conjugated to small molecule derivatives of drugs and endogenous ligands may be useful tools to study the distribution and dynamic of membrane bound receptors, ion channels and transporters in live cells. In order to use these tools, it is necessary to functionalize QDs with bioactive ligands. In this paper, we successfully synthesized a ligand of alpha(1)-adrenoceptor that could be conjugated to QDs. In addition, the conjugation of the ligands to QDs and their biological activity were evaluated through binding assay with 30 nM QD conjugates in living human embryonic kidney 293 cells. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000294714400053
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65421
专题北京大学第三临床医学院_心血管内科
作者单位1.Shandong Univ, Sch Pharm, Jinan 250012, Shandong, Peoples R China
2.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China
3.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Guoheng,Wang, Lei,Ma, Yudao,et al. Synthesis of a quinazoline derivative: A new alpha(1)-adrenoceptor ligand for conjugation to quantum dots to study alpha(1)-adrenoceptors in living cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(19):5905-5909.
APA Zhou, Guoheng,Wang, Lei,Ma, Yudao,Wang, Liping,Zhang, Youyi,&Jiang, Wei.(2011).Synthesis of a quinazoline derivative: A new alpha(1)-adrenoceptor ligand for conjugation to quantum dots to study alpha(1)-adrenoceptors in living cells.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(19),5905-5909.
MLA Zhou, Guoheng,et al."Synthesis of a quinazoline derivative: A new alpha(1)-adrenoceptor ligand for conjugation to quantum dots to study alpha(1)-adrenoceptors in living cells".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.19(2011):5905-5909.
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