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学科主题: 基础医学
题名:
Quantification of liver fat in mice: comparing dual-echo Dixon imaging, chemical shift imaging, and 1H-MR spectroscopy
作者: Peng, Xin-Gui1; Ju, Shenghong1; Qin, Yujiao1; Fang, Fang1; Cui, Xin2,3; Liu, George2,3; Ni, Yicheng4; Teng, Gao-Jun1
关键词: non-alcoholic fatty liver disease ; obesity ; triglyceride ; spin-spin relaxation time T2 ; in vivo ; hydrogen magnetic resonance
刊名: JOURNAL OF LIPID RESEARCH
发表日期: 2011-10-01
DOI: 10.1194/jlr.D016691
卷: 52, 期:10, 页:1847-1855
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: MAGNETIC-RESONANCE-SPECTROSCOPY ; BROWN ADIPOSE-TISSUE ; IN-VIVO ; HEPATIC STEATOSIS ; MR SPECTROSCOPY ; 4.7 TESLA ; DISEASE ; BIOPSY ; WATER ; LIPODYSTROPHIES
英文摘要:

We evaluated dual-echo Dixon in-phase and out-of-phase (IP-OP), chemical shift imaging (CSI), and 1 H MRS (hydrogen MR spectroscopy) in estimating fat content (FC) in phantoms and in livers of mice. Phantoms were made according to the volume percentage of fat ranging from 0% to 100%. The three MR methods were performed to measure FC in phantoms and in livers of obese leptin-deficient (ob/ob), human BSCL2/seipin gene knockout (SKO), and wild-type (WT) mice. The results were compared with known FC in phantoms and to a reference standard from mice by histological semiautomatic vacuole segmentation (HIS-S) procedure and liver lipid (LL) chemical analysis. In phantoms, CSI underestimated FC from 50% to 100%, to a lesser extent than IP-OP. In vivo, liver FC in ob/ob and SKO mice measured by the three MR methods were all significantly higher than that in WT mice. Liver FC measured by IP-OP were significantly lower than that measured by CSI and MRS, with no significant difference between CSI and MRS. CSI and MRS showed a linear correlation with LL analysis and with each other. IP-OP underestimated FC, whereas CSI and MRS were more accurate for quantifying FC in both phantoms and liver. CSI and MRS have the potential to replace HIS-S and LL analysis in longitudinal studies.-Peng, X-G., S. Ju, Y. Qi, F. Fang, X. Cui, G. Liu, Y. Ni, and G-J. Teng. Quantification of liver fat in mice: comparing dual-echo Dixon imaging, chemical shift imaging, and 1H-MR spectroscopy. J. Lipid Res. 2011. 52: 1847-1855.

语种: 英语
所属项目编号: 30830039 ; 81071125 ; 2010CB933903
项目资助者: National Nature Science Foundation of China (NSFC) ; Major State Basic Research Development Program of China (973)
WOS记录号: WOS:000294727500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65422
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Southeast Univ, Zhongda Hosp, Dept Radiol, Lab Mol Imaging, Nanjing 210009, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Cardiovasc Sci, Beijing 10091, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 10091, Peoples R China
4.Catholic Univ Louvain, Univ Hosp, Dept Radiol, B-3000 Louvain, Belgium

Recommended Citation:
Peng, Xin-Gui,Ju, Shenghong,Qin, Yujiao,et al. Quantification of liver fat in mice: comparing dual-echo Dixon imaging, chemical shift imaging, and 1H-MR spectroscopy[J]. JOURNAL OF LIPID RESEARCH,2011,52(10):1847-1855.
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