北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study
作者: Wang, Tiehua1; Liu, Zhuang2; Wang, Zhaoxi5; Duan, Meili2; Li, Gang3; Wang, Shupeng3; Li, Wenxiong4; Zhu, Zhaozhong5; Wei, Yongyue5; Christiani, David C.5; Li, Ang2; Zhu, Xi1
刊名: PLOS ONE
发表日期: 2014-04-14
DOI: 10.1371/journal.pone.0094124
卷: 9, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ACUTE LUNG INJURY ; RISK-FACTORS ; CRITICAL ILLNESS ; PROGNOSIS ; ARDS ; TRANSFUSION ; MULTICENTER ; MECHANISMS ; INFLUENZA ; PLATELET
英文摘要:

Background: Early detection of the Acute Respiratory Distress Syndrome (ARDS) has the potential to improvethe prognosis of critically ill patients admitted to the intensive care unit (ICU). However, no reliable biomarkers are currently available for accurate early detection of ARDS in patients with predisposing conditions.

Objectives: This study examined risk factors and biomarkers for ARDS development and mortality in two prospective cohort studies.

Methods: We examined clinical risk factors for ARDS in a cohort of 178 patients in Beijing, China who were admitted to the ICU and were at high risk for ARDS. Identified biomarkers were then replicated in a second cohort of1,878 patients in Boston, USA.

Results: Of 178 patients recruited from participating hospitals in Beijing, 75 developed ARDS. After multivariate adjustment, sepsis (odds ratio [OR]: 5.58, 95% CI: 1.70-18.3), pulmonary injury (OR: 3.22; 95% CI: 1.60-6.47), and thrombocytopenia, defined as platelet count <80x10(3)/mu L, (OR: 2.67; 95% CI: 1.27-5.62) were significantly associated with increased risk of developing ARDS. Thrombocytopenia was also associated with increased mortality in patients who developed ARDS (adjusted hazard ratio [AHR]: 1.38, 95% CI: 1.07-1.57) but not in those who did not develop ARDS(AHR: 1.25, 95% CI: 0.96-1.62). The presence of both thrombocytopenia and ARDS substantially increased 60-daymortality. Sensitivity analyses showed that a platelet count of <100x10(3)/mu Lin combination with ARDS provide the highest prognostic value for mortality. These associations were replicated in the cohort of US patients.

Conclusions: This study of ICU patients in both China and US showed that thrombocytopenia is associated with an increased risk of ARDS and platelet count in combination with ARDS had a high predictive value for patient mortality.

语种: 英语
所属项目编号: 2009-1014 ; 81372043 ; HL60710
项目资助者: Capital Medical Development Research Fund, Beijing China ; National Natural Science Fund, China ; National Heart, Lung, and Blood Institute USA
WOS记录号: WOS:000336970400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65424
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
2.China Japan Friendship Hosp, Beijing, Peoples R China
3.Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
4.Capital Med Univ, Beijing Friendship Hosp, Beijing, Peoples R China
5.Capital Med Univ, Beijing Chao Yang Hosp, Beijing, Peoples R China

Recommended Citation:
Wang, Tiehua,Liu, Zhuang,Wang, Zhaoxi,et al. Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study[J]. PLOS ONE,2014,9(4).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Tiehua]'s Articles
[Liu, Zhuang]'s Articles
[Wang, Zhaoxi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Tiehua]‘s Articles
[Liu, Zhuang]‘s Articles
[Wang, Zhaoxi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace