IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study
Wang, Tiehua1; Liu, Zhuang2; Wang, Zhaoxi5; Duan, Meili2; Li, Gang3; Wang, Shupeng3; Li, Wenxiong4; Zhu, Zhaozhong5; Wei, Yongyue5; Christiani, David C.5; Li, Ang2; Zhu, Xi1
刊名PLOS ONE
2014-04-14
DOI10.1371/journal.pone.0094124
9期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ACUTE LUNG INJURY ; RISK-FACTORS ; CRITICAL ILLNESS ; PROGNOSIS ; ARDS ; TRANSFUSION ; MULTICENTER ; MECHANISMS ; INFLUENZA ; PLATELET
英文摘要

Background: Early detection of the Acute Respiratory Distress Syndrome (ARDS) has the potential to improvethe prognosis of critically ill patients admitted to the intensive care unit (ICU). However, no reliable biomarkers are currently available for accurate early detection of ARDS in patients with predisposing conditions.

Objectives: This study examined risk factors and biomarkers for ARDS development and mortality in two prospective cohort studies.

Methods: We examined clinical risk factors for ARDS in a cohort of 178 patients in Beijing, China who were admitted to the ICU and were at high risk for ARDS. Identified biomarkers were then replicated in a second cohort of1,878 patients in Boston, USA.

Results: Of 178 patients recruited from participating hospitals in Beijing, 75 developed ARDS. After multivariate adjustment, sepsis (odds ratio [OR]: 5.58, 95% CI: 1.70-18.3), pulmonary injury (OR: 3.22; 95% CI: 1.60-6.47), and thrombocytopenia, defined as platelet count <80x10(3)/mu L, (OR: 2.67; 95% CI: 1.27-5.62) were significantly associated with increased risk of developing ARDS. Thrombocytopenia was also associated with increased mortality in patients who developed ARDS (adjusted hazard ratio [AHR]: 1.38, 95% CI: 1.07-1.57) but not in those who did not develop ARDS(AHR: 1.25, 95% CI: 0.96-1.62). The presence of both thrombocytopenia and ARDS substantially increased 60-daymortality. Sensitivity analyses showed that a platelet count of <100x10(3)/mu Lin combination with ARDS provide the highest prognostic value for mortality. These associations were replicated in the cohort of US patients.

Conclusions: This study of ICU patients in both China and US showed that thrombocytopenia is associated with an increased risk of ARDS and platelet count in combination with ARDS had a high predictive value for patient mortality.

语种英语
WOS记录号WOS:000336970400020
项目编号2009-1014 ; 81372043 ; HL60710
资助机构Capital Medical Development Research Fund, Beijing China ; National Natural Science Fund, China ; National Heart, Lung, and Blood Institute USA
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65424
专题北京大学第三临床医学院
北京大学第三临床医学院_危重医学科
作者单位1.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
2.China Japan Friendship Hosp, Beijing, Peoples R China
3.Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
4.Capital Med Univ, Beijing Friendship Hosp, Beijing, Peoples R China
5.Capital Med Univ, Beijing Chao Yang Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Tiehua,Liu, Zhuang,Wang, Zhaoxi,et al. Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study[J]. PLOS ONE,2014,9(4).
APA Wang, Tiehua.,Liu, Zhuang.,Wang, Zhaoxi.,Duan, Meili.,Li, Gang.,...&Zhu, Xi.(2014).Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study.PLOS ONE,9(4).
MLA Wang, Tiehua,et al."Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study".PLOS ONE 9.4(2014).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Tiehua]的文章
[Liu, Zhuang]的文章
[Wang, Zhaoxi]的文章
百度学术
百度学术中相似的文章
[Wang, Tiehua]的文章
[Liu, Zhuang]的文章
[Wang, Zhaoxi]的文章
必应学术
必应学术中相似的文章
[Wang, Tiehua]的文章
[Liu, Zhuang]的文章
[Wang, Zhaoxi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。