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学科主题: 药学
题名:
A mild and efficient method for the selective cleavage of primary p-methoxybenzyl protecting group of saccharides by Co-2(CO)(8)-Me2PhSiH-CO system
作者: Qian, Peng-zhan1; Yao, Wang1; Huang, Lu-bai1; Meng, Xiang-bao1,2; Li, Zhong-jun1,2
关键词: Co-2(CO)(8) ; Cleavage ; p-Methoxybenzyl ; Regioselectivity
刊名: TETRAHEDRON LETTERS
发表日期: 2015-09-09
DOI: 10.1016/j.tetlet.2015.07.051
卷: 56, 期:37, 页:5238-5241
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ETHERS ; DEPROTECTION ; GLUCOSE
英文摘要:

A mild and efficient method to selectively cleave p-methoxybenzyl (PMB) ether with a catalytic amount of Co-2(CO)(8), hydrosilane and CO (1 atm) is presented. The cleavage reaction shows regioselectivity to primary O-PMB of a variety of permethoxybenzylated saccharides and chemoselectivity to O-Bn, sulfur-containing group and common ester protecting groups. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2012CB822100 ; 2012ZX09502001-001 ; 21232002 ; 20130001110058
项目资助者: National Basic Research Program of China (973 Program) ; National Key Technology R&amp ; D Program &prime ; New Drug Innovation&prime ; of China ; National Natural Science Foundation of China (NSFC) ; National Research Foundation for the Doctoral Program of Higher Education of China ; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University
WOS记录号: WOS:000360597400021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65426
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Peoples R China

Recommended Citation:
Qian, Peng-zhan,Yao, Wang,Huang, Lu-bai,et al. A mild and efficient method for the selective cleavage of primary p-methoxybenzyl protecting group of saccharides by Co-2(CO)(8)-Me2PhSiH-CO system[J]. TETRAHEDRON LETTERS,2015,56(37):5238-5241.
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