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A mild and efficient method for the selective cleavage of primary p-methoxybenzyl protecting group of saccharides by Co-2(CO)(8)-Me2PhSiH-CO system
Qian, Peng-zhan1; Yao, Wang1; Huang, Lu-bai1; Meng, Xiang-bao1,2; Li, Zhong-jun1,2
关键词Co-2(Co)(8) Cleavage P-methoxybenzyl Regioselectivity
刊名TETRAHEDRON LETTERS
2015-09-09
DOI10.1016/j.tetlet.2015.07.051
56期:37页:5238-5241
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]Ethers ; Deprotection ; Glucose
英文摘要

A mild and efficient method to selectively cleave p-methoxybenzyl (PMB) ether with a catalytic amount of Co-2(CO)(8), hydrosilane and CO (1 atm) is presented. The cleavage reaction shows regioselectivity to primary O-PMB of a variety of permethoxybenzylated saccharides and chemoselectivity to O-Bn, sulfur-containing group and common ester protecting groups. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000360597400021
通讯作者邮箱zjli@bjmu.edu.cn
项目编号2012CB822100 ; 2012ZX09502001-001 ; 21232002 ; 20130001110058
资助机构National Basic Research Program of China (973 Program) ; National Key Technology R&D Program ′New Drug Innovation′of China ; National Natural Science Foundation of China (NSFC) ; National Research Foundation for the Doctoral Program of Higher Education of China ; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65426
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Peoples R China
推荐引用方式
GB/T 7714
Qian, Peng-zhan,Yao, Wang,Huang, Lu-bai,et al. A mild and efficient method for the selective cleavage of primary p-methoxybenzyl protecting group of saccharides by Co-2(CO)(8)-Me2PhSiH-CO system[J]. TETRAHEDRON LETTERS,2015,56(37):5238-5241.
APA Qian, Peng-zhan,Yao, Wang,Huang, Lu-bai,Meng, Xiang-bao,&Li, Zhong-jun.(2015).A mild and efficient method for the selective cleavage of primary p-methoxybenzyl protecting group of saccharides by Co-2(CO)(8)-Me2PhSiH-CO system.TETRAHEDRON LETTERS,56(37),5238-5241.
MLA Qian, Peng-zhan,et al."A mild and efficient method for the selective cleavage of primary p-methoxybenzyl protecting group of saccharides by Co-2(CO)(8)-Me2PhSiH-CO system".TETRAHEDRON LETTERS 56.37(2015):5238-5241.
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