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Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-beta(25-35) Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice
Li, Li1; Tsai, Hao-Jan1; Li, Lin2; Wang, Xue-Mei1
关键词Whole-Cell Patch-Clamp Icariin A beta(25-35) Voltage-Gated Calcium Channels (VGCCs) Barium Current CA1
刊名AMERICAN JOURNAL OF CHINESE MEDICINE
2010
DOI10.1142/S0192415X10007701
38期:1页:113-125
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine ; Medicine, General & Internal
研究领域[WOS]Integrative & Complementary Medicine ; General & Internal Medicine
关键词[WOS]LONG-TERM POTENTIATION ; AMYLOID PRECURSOR PROTEIN ; ALZHEIMERS-DISEASE ; CA2+ CHANNELS ; IN-VITRO ; BETA ; CELLS ; NEUROTOXICITY ; INVOLVEMENT ; ALUMINUM
英文摘要

Overload of intracellular calcium caused by amyloid-beta peptide has been implicated in the pathogenesis of neuronal damage in Alzheimer′s disease. Voltage-gated calcium channels (VGCCs) provide one of the major sources of Ca2+ entry into cells. Here, we investigated whether icariin had effect on the changes of calcium currents induced by A beta(25-35) in hippocampal pyramidal neurons. Using whole-cell patch-clamp, we showed that A beta(25-35) enhanced the inward Ba2+ and Ca2+ currents. The currents were partially inhibited by Ni2+ and completely suppressed by Cd2+, indicating that A beta(25-35) disrupts intracellular calcium homeostasis via the modulation of both L-and T-type channels. Furthermore, icariin nearly complete suppressed the abnormal inward calcium currents induced by A beta(25-35) in a dose-dependant manner. Our findings suggest that the potential neuroprotective effect of icariin on A beta(25-35)-induced neurotoxicity via the balance intracelluar calcium homeostasis.

语种英语
WOS记录号WOS:000274268300010
项目编号30672760 ; 2007001707
资助机构National Natural Science Foundation of China (NSFC) ; Ministry of Education of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65430
专题北京大学第一临床医学院
作者单位1.Peking Univ, Dept Cent Lab, Beijing 100034, Peoples R China
2.Peking Univ, Dept Integrated Chinese & Western Med, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Li, Li,Tsai, Hao-Jan,Li, Lin,et al. Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-beta(25-35) Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2010,38(1):113-125.
APA Li, Li,Tsai, Hao-Jan,Li, Lin,&Wang, Xue-Mei.(2010).Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-beta(25-35) Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice.AMERICAN JOURNAL OF CHINESE MEDICINE,38(1),113-125.
MLA Li, Li,et al."Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-beta(25-35) Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice".AMERICAN JOURNAL OF CHINESE MEDICINE 38.1(2010):113-125.
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