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学科主题: 临床医学
题名:
Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-beta(25-35) Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice
作者: Li, Li1; Tsai, Hao-Jan1; Li, Lin2; Wang, Xue-Mei1
关键词: Whole-Cell Patch-Clamp ; Icariin ; A beta(25-35) ; Voltage-Gated Calcium Channels (VGCCs) ; Barium Current ; CA1
刊名: AMERICAN JOURNAL OF CHINESE MEDICINE
发表日期: 2010
DOI: 10.1142/S0192415X10007701
卷: 38, 期:1, 页:113-125
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine ; Medicine, General & Internal
研究领域[WOS]: Integrative & Complementary Medicine ; General & Internal Medicine
关键词[WOS]: LONG-TERM POTENTIATION ; AMYLOID PRECURSOR PROTEIN ; ALZHEIMERS-DISEASE ; CA2+ CHANNELS ; IN-VITRO ; BETA ; CELLS ; NEUROTOXICITY ; INVOLVEMENT ; ALUMINUM
英文摘要:

Overload of intracellular calcium caused by amyloid-beta peptide has been implicated in the pathogenesis of neuronal damage in Alzheimer′s disease. Voltage-gated calcium channels (VGCCs) provide one of the major sources of Ca2+ entry into cells. Here, we investigated whether icariin had effect on the changes of calcium currents induced by A beta(25-35) in hippocampal pyramidal neurons. Using whole-cell patch-clamp, we showed that A beta(25-35) enhanced the inward Ba2+ and Ca2+ currents. The currents were partially inhibited by Ni2+ and completely suppressed by Cd2+, indicating that A beta(25-35) disrupts intracellular calcium homeostasis via the modulation of both L-and T-type channels. Furthermore, icariin nearly complete suppressed the abnormal inward calcium currents induced by A beta(25-35) in a dose-dependant manner. Our findings suggest that the potential neuroprotective effect of icariin on A beta(25-35)-induced neurotoxicity via the balance intracelluar calcium homeostasis.

语种: 英语
所属项目编号: 30672760 ; 2007001707
项目资助者: National Natural Science Foundation of China (NSFC) ; Ministry of Education of China
WOS记录号: WOS:000274268300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65430
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Cent Lab, Beijing 100034, Peoples R China
2.Peking Univ, Dept Integrated Chinese & Western Med, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Li, Li,Tsai, Hao-Jan,Li, Lin,et al. Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-beta(25-35) Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2010,38(1):113-125.
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